Allosteric activation of a G protein-coupled receptor with cell-penetrating receptor mimetics

Journal of Biological Chemistry

Volumn 290, Issue 25, 2015, Pages 15785-15798

  Zhang, Ping ^a   Leger, Andrew J ^a   Baleja, James D ^a   Rana, Rajashree ^a   Corlin, Tiffany ^a   Nguyen, Nga ^a   Koukos, Georgios ^a   Bohm, Andrew ^a   Covic, Lidija ^a   Kuliopulos, Athan ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; DIMERS; PROTEINS;

ALLOSTERIC ACTIVATION; ALLOSTERIC MODULATORS; CONFORMATIONAL CHANGE; G PROTEIN COUPLED RECEPTORS; MECHANISTIC STUDIES; PROTEASE-ACTIVATED RECEPTOR-1; SIGNALING SYSTEMS; SUBUNIT INTERACTIONS;

CELL SIGNALING;

CELL PENETRATING PEPTIDE; G PROTEIN COUPLED RECEPTOR; PALMITATE ARGINYLCYSTEINYLLEUCYLSERYLSERYLSERYLALANYLVALYLALANYLASPARAGINYLARGINYLSERYLLYSYLLYSYLSERYLARGINYLALANYLLEUCYLPHENYLALANINE AMINE; PEPDUCIN; POLYPEPTIDE; PROTEINASE ACTIVATED RECEPTOR 1; UNCLASSIFIED DRUG; BIOMIMETIC MATERIAL; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; HEK293 CELL LINE; METABOLISM;

ALLOSTERIC REGULATION; AMINO ACID MOTIFS; ANIMALS; BIOMIMETIC MATERIALS; CELL-PENETRATING PEPTIDES; CERCOPITHECUS AETHIOPS; COS CELLS; GTP-BINDING PROTEIN ALPHA SUBUNITS; HEK293 CELLS; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECEPTOR, PAR-1;

EID: 84940100059     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.636316     Document Type: Article

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