PCSK9 variation and association with blood pressure in African Americans: Preliminary findings from the HyperGEN and REGARDS studies

Frontiers in Genetics

Volumn 6, Issue APR, 2015, Pages

  Tran, Ngan T ^a   Aslibekyan, Stella ^a   Tiwari, Hemant K ^a   Zhi, Degui ^a   Sung, Yun Ju ^b   Hunt, Steven C ^c   Rao, D C ^b   Broeckel, Ulrich ^d   Judd, Suzanne E ^a   Muntner, Paul ^a   Kent, Shia T ^a   Arnett, Donna K ^a   Irvin, Marguerite R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Blood pressure; Dyslipidemia; Hypertension; Low density lipoprotein cholesterol; PCSK9

Indexed keywords

PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AFRICAN AMERICAN; ARTICLE; DIASTOLIC BLOOD PRESSURE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; HYPERTENSION; MALE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

ANIMALIA;

EID: 84940046533     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2015.00136     Document Type: Article

References (32)

1. Abifadel, M., Rabes, J. P., Devillers, M., Munnich, A., Erlich, D., Junien, C., et al. (2009). Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease. Hum. Mutat. 30, 520-529. doi: 10.1002/humu.20882.
2. Abifadel, M., Varret, M., Rabes, J. P., Allard, D., Ouguerram, K., Devillers, M., et al. (2003). Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat. Genet. 34, 154-156. doi: 10.1038/ng1161.
3. Allison, D. B., Heshka, S., Neale, M. C., and Heymsfield, S. B. (1994). Race effects in the genetics of adolescents' body mass index. Int. J. Obes. Relat. Metab. Disord. 18, 363-368.
4. Arnett, D. K., Meyers, K. J., Devereux, R. B., Tiwari, H. K., Gu, C. C., Vaughan, L. K., et al. (2011). Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. Circ. Res. 108, 279-283. doi: 10.1161/circresaha.110.239210.
5. Barrett, J. C., Fry, B., Maller, J., and Daly, M. J. (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265. doi: 10.1093/bioinformatics/bth457.
6. Benjannet, S., Rhainds, D., Essalmani, R., Mayne, J., Wickham, L., Jin, W., et al. (2004). NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J. Biol. Chem. 279, 48865-48875. doi: 10.1074/jbc.M409699200.
7. Berger, J. M., Vaillant, N., Le May, C., Calderon, C., Bregeon, J., Prieur, X., et al. (2015). PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. Atherosclerosis 239, 252-259. doi: 10.1016/j.atherosclerosis.2015.01.012.
8. Brown, C. D., Higgins, M., Donato, K. A., Rohde, F. C., Garrison, R., Obarzanek, E., et al. (2000). Body mass index and the prevalence of hypertension and dyslipidemia. Obes. Res. 8, 605-619. doi: 10.1038/oby.2000.79.
9. Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L. Jr., et al. (2003). Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 42, 1206-1252. doi: 10.1161/01.HYP.0000107251.49515.c2.
10. Chrysant, S. G. (2013). Treating blood pressure to prevent strokes: the age factor. World J. Cardiol. 5, 22-27. doi: 10.4330/wjc.v5.i3.22.
11. Egan, B. M., Zhao, Y., and Axon, R. N. (2010). US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA 303, 2043-2050. doi: 10.1001/jama.2010.650.
12. Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., et al. (2014). Executive summary: heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation 129, 399-410. doi: 10.1161/01.cir.0000442015.53336.12.
13. Halperin, R. O., Sesso, H. D., Ma, J., Buring, J. E., Stampfer, M. J., and Gaziano, J. M. (2006). Dyslipidemia and the risk of incident hypertension in men. Hypertension 47, 45-50. doi: 10.1161/01.HYP.0000196306.42418.0e.
14. Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2007). Molecular biology of PCSK9: its role in LDL metabolism. Trends Biochem. Sci. 32, 71-77. doi: 10.1016/j.tibs.2006.12.008.
15. Howard, V. J., Cushman, M., Pulley, L., Gomez, C. R., Go, R. C., Prineas, R. J., et al. (2005). The reasons for geographic and racial differences in stroke study: objectives and design. Neuroepidemiology 25, 135-143. doi: 10.1159/000086678.
16. Kato, N. (2012). Ethnic differences in genetic predisposition to hypertension. Hypertens. Res. 35, 574-581. doi: 10.1038/hr.2012.44.
17. Knox, S. S., Guo, X., Zhang, Y., Weidner, G., Williams, S., and Ellison, R. C. (2010). AGT M235T genotype/anxiety interaction and gender in the HyperGEN study. PLoS ONE 5:e13353. doi: 10.1371/journal.pone.0013353.
18. Kramer, H., Han, C., Post, W., Goff, D., Diez-Roux, A., Cooper, R., et al. (2004). Racial/ethnic differences in hypertension and hypertension treatment and control in the multi-ethnic study of atherosclerosis (MESA). Am. J. Hypertens. 17, 963-970. doi: 10.1016/j.amjhyper.2004.06.001.
19. Lackland, D. T. (2014). Racial differences in hypertension: implications for high blood pressure management. Am. J. Med. Sci. 348, 135-138. doi: 10.1097/maj.0000000000000308.
20. Maharjan, B. R., Bhandary, S., Sunuwar, L., Shrestha, A., and Ranjitkar, N. (2012). Association of hypertension with microalbuminuria and lipid profile in the local population of Patan. Nepal Med. Coll. J. 14, 157-162.
21. Nguyen, N. T., Magno, C. P., Lane, K. T., Hinojosa, M. W., and Lane, J. S. (2008). Association of hypertension, diabetes, dyslipidemia, and metabolic syndrome with obesity: findings from the National Health and Nutrition Examination Survey, 1999 to 2004. J. Am. Coll. Surg. 207, 928-934. doi: 10.1016/j.jamcollsurg.2008.08.022.
22. Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., and Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904-909. doi: 10.1038/ng1847.
23. Schunkert, H., Konig, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., et al. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 43, 333-338. doi: 10.1038/ng.784.
24. Sesso, H. D., Buring, J. E., Chown, M. J., Ridker, P. M., and Gaziano, J. M. (2005). A prospective study of plasma lipid levels and hypertension in women. Arch. Intern. Med. 165, 2420-2427. doi: 10.1001/archinte.165.20.2420.
25. Sharotri, V., Collier, D. M., Olson, D. R., Zhou, R., and Snyder, P. M. (2012). Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9). J. Biol. Chem. 287, 19266-19274. doi: 10.1074/jbc.M112.363382.
26. Tobin, M. D., Sheehan, N. A., Scurrah, K. J., and Burton, P. R. (2005). Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat. Med. 24, 2911-2935. doi: 10.1002/sim.2165.
27. Turnbull, C., Perdeaux, E. R., Pernet, D., Naranjo, A., Renwick, A., Seal, S., et al. (2012). A genome-wide association study identifies susceptibility loci for Wilms tumor. Nat. Genet. 44, 681-684. doi: 10.1038/ng.2251.
28. Ward, L. D., and Kellis, M. (2012). HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 40, D930-D934. doi: 10.1093/nar/gkr917.
29. Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., et al. (2013). Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45, 1274-1283. doi: 10.1038/ng.2797.
30. Williams, R. R., Rao, D. C., Ellison, R. C., Arnett, D. K., Heiss, G., Oberman, A., et al. (2000). NHLBI family blood pressure program: methodology and recruitment in the HyperGEN network. Hypertension genetic epidemiology network. Ann. Epidemiol. 10, 389-400.
31. Wu, M. C., Lee, S., Cai, T., Li, Y., Boehnke, M., and Lin, X. (2011). Rare-variant association testing for sequencing data with the sequence kernel association test. Am. J. Hum. Genet. 89, 82-93. doi: 10.1016/j.ajhg.2011.05.029.
32. Yin, R. X., Wu, J. Z., Liu, W. Y., Wu, D. F., Cao, X. L., Miao, L., et al. (2012). Association of several lipid-related gene polymorphisms and blood pressure variation in the Bai Ku Yao population. Am. J. Hypertens. 25, 927-936. doi: 10.1038/ajh.2012.55.