Association of several lipid-related gene polymorphisms and blood pressure variation in the Bai Ku Yao population

American Journal of Hypertension

Volumn 25, Issue 8, 2012, Pages 927-936

  Yin, Rui Xing ^a   Wu, Jin Zhen ^a   Liu, Wan Ying ^a   Wu, Dong Feng ^a   Cao, Xiao Li ^a   Miao, Lin ^a   Htet Aung, Lynn Htet ^a   Zhang, Lin ^b   Long, Xing Jiang ^a   Li, Meng ^c   Pan, Shang Ling ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

^b People's Hospital of Guilin   (China)

^c Worker's Hospital of Guangxi Liuzhou Iron and Steel Group Company   (China)

Author keywords

blood pressure; genetic polymorphism; hypertension; sex difference

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ABC TRANSPORTER A1; ACYL COENZYME A; ENDOTHELIAL LIPASE; LIPID; LIVER TRIACYLGLYCEROL LIPASE; LOW DENSITY LIPOPROTEIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROPROTEIN CONVERTASE SUBTILISIN LIKE KEXIN TYPE 9; PROTEIN; SCAVENGER RECEPTOR BI; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE VARIABILITY; CHINA; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD PRESSURE; ETHNIC GROUPS; FEMALE; HUMANS; HYPERTENSION; LIPASE; LIPID METABOLISM; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; PPAR DELTA; PROPROTEIN CONVERTASES; RECEPTORS, LDL; SCAVENGER RECEPTORS, CLASS B; SERINE ENDOPEPTIDASES; SEX FACTORS; STEROL O-ACYLTRANSFERASE;

EID: 84864290506     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1038/ajh.2012.55     Document Type: Article

References (40)

1. Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodríguez-Artalejo F, Stegmayr B, Thamm M, Tuomilehto J, Vanuzzo D, Vescio F. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA 2003; 289:2363-2369. (Pubitemid 37430168)
2. Castelli W P, Anderson K. A population at risk. Prevalence of high cholesterol levels in hypertensive patients in the Framingham Study. Am J Med 1986; 80:23-32. (Pubitemid 16131300)
3. Selby JV, Newman B, Quiroga J, Christian JC, Austin MA, Fabsitz RR. Concordance for dyslipidemic hypertension in male twins. JAMA 1991; 265:2079-2084.
4. Hunt SC, Stephenson SH, Hopkins PN, Williams RR. Predictors of an increased risk of future hypertension in Utah. A screening analysis. Hypertension 1991; 17: 969-976.
5. Halperin RO, Sesso HD, Ma J, Buring JE, Stampfer MJ, Gaziano JM. Dyslipidemia and the risk of incident hypertension in men. Hypertension 2006; 47:45-50. (Pubitemid 43177814)
6. Shen BJ, Todaro JF, Niaura R, McCaffery JM, Zhang J, Spiro A 3rd, Ward KD. Are metabolic risk factors one unified syndrome? Modeling the structure of the metabolic syndrome X. Am J Epidemiol 2003; 157:701-711. (Pubitemid 36423083)
7. Allayee H, de Bruin TW, Michelle Dominguez K, Cheng LS, Ipp E, Cantor RM, Krass KL, Keulen ET, Aouizerat BE, Lusis AJ, Rotter JI. Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. Hypertension 2001; 38:773-778. (Pubitemid 34258669)
8. Franceschini N, Reiner A P, Heiss G. Recent findings in the genetics of blood pressure and hypertension traits. Am J Hypertens 2011; 24:392-400.
9. Ruixing Y, Weixiong L, Hanjun Y, Dezhai Y, Shuquan L, Shangling P, Qiming F, Jinzhen W, Jianting G, Yaju D. Diet, lifestyle, and blood pressure of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations. Am J Hypertens 2008; 21:382-387. (Pubitemid 351450865)
10. Cao XL, Yin RX, Wu DF, Miao L, Aung LH, Hu XJ, Li Q, Yan T T, Lin WX, Pan SL. Genetic variant of V825I in the ATP-binding cassette transporter A1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis 2011; 10:14.
11. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112:2735-2752. (Pubitemid 41532612)
12. Cohen HW. P values: use and misuse in medical literature. Am J Hypertens 2011; 24:18-23.
13. Xu M, Zhou H, Gu Q, Li C. The expression of ATP-binding cassette transporters in hypertensive patients. Hypertens Res 2009; 32:455-461.
14. Yamada Y, Kato K, Yoshida T, Yokoi K, Matsuo H, Watanabe S, Ichihara S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y. Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals. Int J Mol Med 2008; 21:83-89. (Pubitemid 351222872)
15. Zee RY, Griffiths LR, Morris BJ. Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives. Biochem Biophys Res Commun 1992; 189:965-971. (Pubitemid 23032469)
16. Morris BJ, Zee RY, Robinson BG. Significant relationships of plasma lipids and body mass index with polymorphisms at the linked low-density- lipoprotein receptor gene and insulin receptor gene loci (19p13.2) in essential hypertensive patients. Clin Sci 1994; 86:583-592. (Pubitemid 24181947)
17. Zee RY, Schrader A P, Robinson BG, Griffiths LR, Morris BJ. Association of HincII RFLP of low density lipoprotein receptor gene with obesity in essential hypertensives. Clin Genet 1995; 47:118-121.
18. Fu Y, Katsuya T, Higaki J, Asai T, Fukuda M, Takiuchi S, Hatanaka Y, Rakugi H, Ogihara T. A common mutation of low-density lipoprotein receptor gene is associated with essential hypertension among Japanese. J Hum Hypertens 2001; 15:125-130. (Pubitemid 32170867)
19. Liljedahl U, Lind L, Kurland L, Berglund L, Kahan T, Syvänen AC. Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment. BMC Cardiovasc Disord 2004; 4:16.
20. Liu A P, Zhan SY, Li LM, Hu YH, Cao WH, Wu T, Li J, Guo XX. Association between AvaII exon 13 polymorphism at the LDL receptor gene different and serum lipid levels in normotensives and essential hypertensives in Shanghai. Zhonghua Liu Xing Bing Xue Za Zhi 2003; 24:542-546.
21. Bernard N, Girouard J, Forest JC, Giguère Y. The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension. J Hum Genet 2007; 52:244-254.
22. Kokubo Y, Tomoike H, Tanaka C, Banno M, Okuda T, Inamoto N, Kamide K, Kawano Y, Miyata T. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. Hypertens Res 2006; 29:611-619. (Pubitemid 44430470)
23. Shimokawa Y, Hirata K, Ishida T, Kojima Y, Inoue N, Quertermous T, Yokoyama M. Increased expression of endothelial lipase in rat models of hypertension. Cardiovasc Res 2005; 66:594-600. (Pubitemid 40725771)
24. Yamaguchi S, Yamada Y, Metoki N, Yoshida H, Satoh K, Ichihara S, Kato K, Kameyama T, Yokoi K, Matsuo H, Segawa T, Watanabe S, Nozawa Y. Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis. Int J Mol Med 2006; 18: 871-883.
25. Shimizu M, Kanazawa K, Hirata K, Ishida T, Hiraoka E, Matsuda Y, Iwai C, Miyamoto Y, Hashimoto M, Kajiya T, Akita H, Yokoyama M. Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels. Circ J 2007; 71:842-846. (Pubitemid 46833920)
26. Rodríguez-Esparragón F, Hernández-Perera O, Rodríguez-Pérez JC, Anábitarte A, Díaz-Cremades JM, Losada A, Fiuza D, Hernández E, Yunis C, Ferrario CM. The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values. Clin Exp Hypertens 2003; 25:209-220. (Pubitemid 36644688)
27. Kosmas I P, Tatsioni A, Ioannidis J P. Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis. J Hypertens 2004; 22: 1655-1662. (Pubitemid 39141952)
28. Jiang S, Hsu YH, Xu X, Xing H, Chen C, Niu T, Zhang Y, Peng S, Xu X. The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor. Thromb Res 2004; 113:361-369. (Pubitemid 38844366)
29. Jiang S, Hsu YH, Niu T, Xu X, Xing H, Chen C, Wang X, Zhang Y, Peng S, Xu X. A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients-a family-based association study. Clin Exp Hypertens 2005; 27:509-521. (Pubitemid 41170282)
30. Qian X, Lu Z, Tan M, Liu H, Lu D. A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension. Eur J Hum Genet 2007; 15:1239-1245. (Pubitemid 350143180)
31. Markan S, Sachdeva M, Sehrawat BS, Kumari S, Jain S, Khullar M. MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians. Mol Cell Biochem 2007; 302:125-131. (Pubitemid 47202328)
32. Marinho C, Alho I, Arduíno D, Falcão LM, Brás-Nogueira J, Bicho M. GST M1/T1 and MTHFR polymorphisms as risk factors for hypertension. Biochem Biophys Res Commun 2007; 353:344-350. (Pubitemid 46014571)
33. Ilhan N, Kucuksu M, Kaman D, Ilhan N, Ozbay Y. The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. Arch Med Res 2008; 39:125-130. (Pubitemid 350192019)
34. Ravera M, Viazzi F, Berruti V, Leoncini G, Zagami P, Bezante G P, Rosatto N, Ravazzolo R, Pontremoli R, Deferrari G. 5, 10-Methylenetetrahydrofolate reductase polymorphism and early organ damage in primary hypertension. Am J Hypertens 2001; 14:371-376.
35. Lwin H, Yokoyama T, Yoshiike N, Saito K, Yamamoto A, Date C, Tanaka H. Polymorphism of methylenetetrahydrofolate reductase gene (C677T MTHFR) is not a confounding factor of the relationship between serum uric acid level and the prevalence of hypertension in Japanese men. Circ J 2006; 70:83-87. (Pubitemid 43021239)
36. Stiefel P, Miranda ML, Bellido LM, Luna J, Jiménez L, Pamies E, de Frutos PG, Villar J. Genotype of the CYBA promoter-930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: an observational study. Med Clin (Barc) 2009; 133:657-661.
37. Cui Q, Ju X, Yang T, Zhang M, Tang W, Chen Q, Hu Y, Haas JV, Troutt JS, Pickard RT, Darling R, Konrad RJ, Zhou H, Cao G. Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population. Atherosclerosis 2010; 213:632-636.
38. Gao L, Wang L, Yun H, Su L, Su X. Association of the PPARgamma2 gene Pro12Ala variant with primary hypertension and metabolic lipid disorders in Han Chinese of Inner Mongolia. Genet Mol Res 2010; 9:1312-1320.
39. Ostgren CJ, Lindblad U, Melander O, Melander A, Groop L, Råstam L. Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: skaraborg hypertension and diabetes project. J Hypertens 2003; 21:1657-1662. (Pubitemid 37076348)
40. Yan ZC, Shen CY, Zhong J, Wang L, Ni YX, Nie H, Zhu ZM. PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left ventricular hypertrophy in subjects with metabolic syndrome. Zhonghua Xin Xue Guan Bing Za Zhi 2005; 33:529-533. (Pubitemid 41135742)