Elevated endothelial hypoxia-inducible factor-1α contributes to glomerular injury and promotes hypertensive chronic kidney disease

Hypertension

Volumn 66, Issue 1, 2015, Pages 75-84

  Luo, Renna ^a,b   Zhang, Weiru ^b   Zhao, Cheng ^a,b   Zhang, Yujin ^b   Wu, Hongyu ^b   Jin, Jianping ^b,c   Zhang, Wenzheng ^b,c   Grenz, Almut ^d   Eltzschig, Holger K ^d   Tao, Lijian ^a   Kellems, Rodney E ^b,c   Xia, Yang ^a,b,c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

angiotensin II; hypertension; hypoxia inducible factor 1, alpha; renal insufficiency, chronic

Indexed keywords

ANGIOTENSIN II; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; CADHERIN; ENDOTHELIN 1; HIF1A PROTEIN, HUMAN; HIF1A PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; SMALL INTERFERING RNA; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DISEASE COURSE; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERTENSION; HYPERTENSIVE CHRONIC KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD; CELL CULTURE; CHEMICALLY INDUCED; COMPLICATION; DRUG EFFECTS; FEEDBACK SYSTEM; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; GLOMERULUS; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RENAL INSUFFICIENCY, CHRONIC; TRANSGENIC MOUSE; UPREGULATION; VASCULAR ENDOTHELIUM;

ANGIOTENSIN II; ANIMALS; ANTIGENS, CD; CADHERINS; CELLS, CULTURED; DISEASE PROGRESSION; ENDOTHELIAL CELLS; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FEEDBACK, PHYSIOLOGICAL; FIBROSIS; GENE EXPRESSION REGULATION; HUMANS; HYPERTENSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY GLOMERULUS; MICE; MICE, TRANSGENIC; NF-KAPPA B; ORGAN CULTURE TECHNIQUES; RENAL INSUFFICIENCY, CHRONIC; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84940044454     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05578     Document Type: Article

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