Alternation of histone and DNA methylation in human atherosclerotic carotid plaques

Thrombosis and Haemostasis

Volumn 114, Issue 2, 2015, Pages 390-402

  Greißel, Anna ^a   Culmes, Mihaela ^a   Napieralski, Rudolf ^a   Wagner, Ernst ^b   Gebhard, Harry ^c   Schmitt, Manfred ^a   Zimmermann, Alexander ^a   Eckstein, Hans Henning ^a,d   Zernecke, Alma ^a,d,e   Pelisek, Jaroslav ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c Kantonsspital Liestal   (Switzerland)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^e UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Atherosclerosis; Carotid artery; DNA and histone methylation; Epigenetics; Methyltransferases

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B; GENOMIC DNA; HISTONE; LINE 1 PROTEIN; MESSENGER RNA; SAT ALPHA PROTEIN; TET 1 PROTEIN; UNCLASSIFIED DRUG; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DNA BINDING PROTEIN; EHMT2 PROTEIN, HUMAN; HISTOCOMPATIBILITY ANTIGEN; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; MLL2 PROTEIN, HUMAN; ONCOPROTEIN; TET1 PROTEIN, HUMAN; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CAROTID ARTERY OBSTRUCTION; CAROTID ATHEROSCLEROSIS; CONTROLLED STUDY; DNA EXTRACTION; DNA METHYLATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING; ATHEROSCLEROTIC PLAQUE; BLOOD CELL; CAROTID ARTERY; CAROTID ARTERY DISEASE; COMPARATIVE STUDY; DISEASE COURSE; ENZYME INDUCTION; GENETICS; INFLAMMATION; LEUKOCYTE; LONG INTERSPERSED REPEAT; METABOLISM; METHYLATION; MIDDLE AGED; PATHOLOGY; PROTEIN PROCESSING; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

AGED; BLOOD CELLS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; DISEASE PROGRESSION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA-BINDING PROTEINS; ENZYME INDUCTION; FEMALE; HISTOCOMPATIBILITY ANTIGENS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; INFLAMMATION; LEUKOCYTES; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; LYSINE; MACROPHAGES; MALE; METHYLATION; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOPLASM PROTEINS; PLAQUE, ATHEROSCLEROTIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84940033962     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-10-0852     Document Type: Article

References (51)

1. Nimura K, Ura K, Kaneda Y. Histone methyltransferases: regulation of transcription and contribution to human disease. J Mol Med 2010; 88: 1213–1220.
2. Wu SC, Zhang Y. Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol 2010; 11: 607–620.
3. Campos EI, Reinberg D. Histones: annotating chromatin. Annu Rev Genet 2009; 43: 559–599.
4. Szyf M. Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 2009; 49: 243–263.
5. Szyf M. Targeting DNA methylation in cancer. Bull Cancer 2006; 93: 961–972.
6. Cedar H, Bergman Y. Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet 2009; 10: 295–304.
7. Kondo Y. Epigenetic cross-talk between DNA methylation and histone modifications in human cancers. Yonsei Med J 2009; 50: 455–463.
8. Ivanova T, Vinokurova S, Petrenko A, et al. Frequent hypermethylation of 5’ flanking region of TIMP-2 gene in cervical cancer. Int J Cancer 2004; 108: 882–886.
9. Boumber Y, Issa JP. Epigenetics in cancer: what’s the future? Oncology 2011; 25: 220–226.
10. Shima K, Morikawa T, Baba Y, et al. MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. Cancer Causes Control 2011; 22: 301–309.
11. Pavicic W, Joensuu EI, Nieminen T, Peltomäki P. LINE-1 hypomethylation in familial and sporadic cancer. J Mol Med 2012; 90: 827–835.
12. Dong C, Yoon W, Goldschmidt-Clermont PJ. DNA Methylation and Atherosclerosis. J Nutr 2002; 132: 2406S-2409S.
13. Castillo-Díaz SA, Garay-Sevilla ME, Hernández-González MA, et al. Extensive demethylation of normally hypermethylated CpG islands occurs in human atherosclerotic arteries. Int J Mol Med 2010; 26: 691–700.
14. Turunen, MP, Ylä-Herttuala S. Epigenetic regulation of key vascular genes and growth factors. Cardiovasc Res 2011; 90: 441–446.
15. Ordovás JM, Smith CE. Epigenetics and cardiovascular disease. Nat Rev Cardiol 2010; 7: 510–519.
16. Hiltunen MO, Turunen MP, Häkkinen TP, et al. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vasc Med 2002; b7: b5–11.
17. Baccarelli A, Tarantini L, Wright RO, et al. Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study. Epigenetics 2010; 5: 222–228.
18. Choi SH, Heo K, Byun HM, et al. Identification of preferential target sites for human DNA methyltransferases. Nucleic Acids Res 2011; 39: 104–118.
19. Timaran CH, McKinsey JF, Schneider PA, et al. Reporting standards for carotid interventions from the Society for Vascular Surgery. J Vasc Surg 2011; 53: 1679–1695.
20. Stary HC, Chandler AB, Glagov S, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. Circulation 1994; 89: 2462–2478.
21. Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. Circulation 1995; 92: 1355–1374.
22. Reeps C, Pelisek J, Seidl S, et al. Inflammatory infiltrates and neovessels are relevant sources of MMPs in abdominal aortic aneurysm wall. Pathobiology 2009; 76: 243–252.
23. Pelisek J, Well G, Reeps C, et al. Neovascularization and angiogenic factors in advanced human carotid artery stenosis. Circ J 2012; 76: 1274–1282.
24. Lipp C, Lohoefer F, Reeps C, et al. Expression of a disintegrin and metalloprotease in human abdominal aortic aneurysms. J Vasc Res 2012; 49: 198–206.
25. Weisenberger DJ, Campan M, Long TI, et al. Analysis of repetitive element DNA methylation by MethyLight. Nucleic acids Res 2008; 33: 823–836.
26. Santos-Rosa H, Caldas C. Chromatin modifier enzymes, the histone code and cancer. Eur J Cancer 2005; 41: 2381–2402.
27. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc 1995; 57: 298–300.
28. Begum S, Brait M, Dasgupta S, Ostrow KL, Zahurak M, Carvalho AL, Califano JA, Goodman SN, Westra WH, Hoque MO, et al. An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin Cancer Res 2011; 17: 4494–4503.
29. de Martino M, Klatte T, Haitel A, et al. Serum cell-free DNA in renal cell carcinoma: a diagnostic and prognostic marker. Cancer 2012; 118: 82–90.
30. Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 2012; 13: 343–357.
31. Alexander MR, Owens GK. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease. Annu Rev Physiol 2012; 74: 13–40.
32. Martin C1, Zhang Y. The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 2005; 6: 838–849.
33. Rose CM, van den Driesche S, Meehan RR, et al. Epigenetic reprogramming: preparing the epigenome for the next generation. Biochem Soc Trans 2013; 41: 809–814.
34. Bessler JBL, Andersen EC, Villeneuve AM. Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line. PLoS Genet 2010; 6: e1000830.
35. Lacolley P, Regnault V, Nicoletti A, Li Z, et al. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovasc Res 2012; 95: 194–204.
36. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 2002.90: 251–262.
37. Manabe I, Owens GK. Recruitment of serum response factor and hyperacetylation of histones at smooth muscle-specific regulatory regions during differentiation of a novel P19-derived in vitro smooth muscle differentiation system. Circ Res 2001; 88: 1127–1134.
38. De Santa F, Totaro MG, Prosperini E, et al. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 2007; 130: 1083–1094.
39. Ruthenburg AJ, Allis CD, Wysocka J. Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell 2007; 25: 15–30.
40. Andreu-Vieyra CV, Chen R, Agno JE, et al. MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol 2010; 8: e1000453.
41. Spin JM, Quertermous T, Tsao PS. Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300. PLoS One 2010; 5: e14301.
42. Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009; 324: 930–935.
43. Wu H, Zhang Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev 2011; 25: 2436–2452.
44. Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 2009; 324: 929–930.
45. Stenvinkel P, Karimi M, Johansson S, et al. Impact of inflammation on epigenetic DNA methylation – a novel risk factor for cardiovascular disease? J Intern Med 2007; 261: 488–499.
46. Qi J, Qian C, Shi W, et al. Alu-based cell-free DNA: a potential complementary biomarker for diagnosis of colorectal cancer. Clin Biochem. 2013; 46: 64–69.
47. Yu J, Gu G, Ju S. Recent advances in clinical applications of circulating cell-free DNA integrity. Lab Med 2014; 45: 6–11.
48. Martinet W, Schrijvers DM, De Meyer GR. Necrotic cell death in atherosclerosis. Basic Res Cardiol 2011; 106: 749–760.
49. Liuzzo G, Giubilato G, Pinnelli M. T cells and cytokines in atherogenesis. Lupus 2005; 14: 732–735.
50. Tamaru H, Selker EU. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 2001; 414: 277–283.
51. Wang J, Hevi S, Kurash JK, et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet 2009; 41: 125–129.