Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus

Neuropharmacology

Volumn 99, Issue , 2015, Pages 422-431

  Pablos, Patricia ^a   Mendiguren, Aitziber ^a   Pineda, Joseba ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Cyclic guanosine monophosphate; Firing; Locus coeruleus; Nitric oxide; Reactive oxygen species; Slice; Opioid receptor

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL] 5 MORPHOLINO 4,6 PYRIMIDINEDIAMINE; 21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; 3 [2 (4 CHLOROPHENYLTHIO)PHENYL] N (4 DIMETHYLAMINOBUTYL)ACRYLAMIDE; 3,3 BIS(2 AMINOETHYL) 1 HYDROXY 2 OXOTRIAZENE; 7 NITROINDAZOLE; 8 (4 CHLOROPHENYLTHIO) CYCLIC GMP; ENZYME ACTIVATOR; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; MELATONIN; METENKEPHALIN; MU OPIATE RECEPTOR; N (2 [METHYLAMINO]ETHYL) 5 ISOQUINOLINE SULFONAMIDE; NITRIC OXIDE DEPENDENT GUANYLATE CYCLASE; NS 2028; REACTIVE OXYGEN METABOLITE; RP BETA PHENYL 1,N2 ETHENO 8 BROMOGUANOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; TROLOX C; UNCLASSIFIED DRUG; ANTIOXIDANT; CYCLIC GMP DEPENDENT PROTEIN KINASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NOS1 PROTEIN, RAT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; IN VITRO STUDY; LOCUS CERULEUS; MALE; NONHUMAN; PERFUSION; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; ACTION POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; METABOLISM; MICROELECTRODE; NERVE CELL; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TISSUE CULTURE TECHNIQUE;

ACTION POTENTIALS; ANIMALS; ANTIOXIDANTS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; GUANYLATE CYCLASE; LOCUS COERULEUS; MALE; MICROELECTRODES; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES;

EID: 84940029728     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.08.004     Document Type: Article

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