Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 39, 2010, Pages 17011-17016

  Cao, Jun Li ^a   Vialou, Vincent F ^b   Lobo, Mary Kay ^b   Robison, Alfred J ^b   Neve, Rachael L ^c   Cooper, Donald C ^a   Nestler, Eric J ^a,b   Han, Ming Hu ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Adenylyl cyclase; Firing adaptation; Intrinsic plasticity; Opiate dependence withdrawal

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; MORPHINE; ADENYLYL CYCLASE 8; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSFER; HOMEOSTASIS; LOCUS CERULEUS; MOUSE; NERVE CELL; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; UPREGULATION; ADAPTATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; GENE INACTIVATION; GENETICS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

MUS;

ADAPTATION, PHYSIOLOGICAL; ADENYLATE CYCLASE; ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE KNOCKOUT TECHNIQUES; HOMEOSTASIS; LOCUS COERULEUS; MICE; MICE, TRANSGENIC; MORPHINE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78049307004     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010077107     Document Type: Article

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