Enhancement of MHC-I Antigen Presentation via Architectural Control of pH-Responsive, Endosomolytic Polymer Nanoparticles

AAPS Journal

Volumn 17, Issue 2, 2015, Pages 358-369

  Wilson, John T ^a,c   Postma, Almar ^b   Keller, Salka ^a   Convertine, Anthony J ^a   Moad, Graeme ^b   Rizzardo, Ezio ^b   Meagher, Laurence ^b   Chiefari, John ^b   Stayton, Patrick S ^a  

^a University of Washington   (United States)

^b CSIRO   (Australia)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

MHC I antigen presentation; pH responsive nanoparticle; polymer architecture; RAFT polymerization; vaccine

Indexed keywords

ACRYLAMIDE DERIVATIVE; CROSS LINKING REAGENT; HLA ANTIGEN CLASS 1; MICELLE; N,N-DIMETHYLACRYLAMIDE; NANOPARTICLE; OVALBUMIN; POLYMER; VACCINE;

ANIMAL; ANTIGEN PRESENTATION; CD8+ T LYMPHOCYTE; CHEMISTRY; DRUG EFFECTS; ENDOSOME; HEMOLYSIS; HUMAN; IMMUNOLOGY; METABOLISM; MICELLE; MOUSE; PH;

ACRYLAMIDES; ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CROSS-LINKING REAGENTS; ENDOSOMES; HEMOLYSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICELLES; NANOPARTICLES; OVALBUMIN; POLYMERS; VACCINES;

EID: 84940000854     PISSN: None     EISSN: 15507416     Source Type: Journal    
DOI: 10.1208/s12248-014-9697-1     Document Type: Article

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