Encapsulating immunostimulatory CpG oligonucleotides in listeriolysin O-liposomes promotes a Th1-type response and CTL activity

Molecular Pharmaceutics

Volumn 9, Issue 5, 2012, Pages 1118-1125

  Andrews, Chasity D ^a   Huh, Myung Sook ^a   Patton, Kathryn ^b   Higgins, Debbie ^b   Van Nest, Gary ^b   Ott, Gary ^b   Lee, Kyung Dall ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Dynavax Technologies Corporation   (United States)

Author keywords

ISS ODN; liposome; listeriolysin O

Indexed keywords

CD8 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 5; LISTERIOLYSIN O; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; ENCAPSULATION; FEMALE; IMMUNOLOGICAL MONITORING; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VITRO STUDY; LIMIT OF DETECTION; LIPOSOMAL DELIVERY; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BACTERIAL TOXINS; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; INTERFERON-GAMMA; INTERLEUKIN-12; LIPOSOMES; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS;

EID: 84860756078     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2003835     Document Type: Article

References (30)

1. Guy, B. The perfect mix: recent progress in adjuvant research Nat. Rev. Microbiol. 2007, 5, 505-17
2. Ott, G.; Barchfeld, G. L.; Van Nest, G. Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59 Vaccine 1995, 13, 1557-62
3. Salerno-Goncalves, R.; Sztein, M. B. Cell-mediated immunity and the challenges for vaccine development Trends Microbiol. 2006, 14, 536-42
4. Datta, S. K.; Cho, H. J.; Takabayashi, K.; Horner, A. A.; Raz, E. Antigen-immunostimulatory oligonucleotide conjugates: mechanisms and applications Immunol. Rev. 2004, 199, 217-26
5. Pashine, A.; Valiante, N. M.; Ulmer, J. B. Targeting the innate immune response with improved vaccine adjuvants Nat. Med. 2005, 11, S63-8
6. Lee, K. D.; Oh, Y. K.; Portnoy, D. A.; Swanson, J. A. Delivery of macromolecules into cytosol using liposomes containing hemolysin from Listeria monocytogenes J. Biol. Chem. 1996, 271, 7249-52
7. Krieg, A. M. CpG motifs in bacterial DNA and their immune effects Annu. Rev. Immunol. 2002, 20, 709-60
8. Latz, E.; Schoenemeyer, A.; Visintin, A.; Fitzgerald, K. A.; Monks, B. G.; Knetter, C. F.; Lien, E.; Nilsen, N. J.; Espevik, T.; Golenbock, D. T. TLR9 signals after translocating from the ER to CpG DNA in the lysosome Nat. Immunol. 2004, 5, 190-8
9. Cho, H. J.; Takabayashi, K.; Cheng, P. M.; Nguyen, M. D.; Corr, M.; Tuck, S.; Raz, E. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism Nat. Biotechnol. 2000, 18, 509-14
10. Tighe, H.; Takabayashi, K.; Schwartz, D.; Marsden, R.; Beck, L.; Corbeil, J.; Richman, D. D.; Eiden, J. J., Jr.; Spiegelberg, H. L.; Raz, E. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity Eur. J. Immunol. 2000, 30, 1939-47
11. Heit, A.; Schmitz, F.; O'Keeffe, M.; Staib, C.; Busch, D. H.; Wagner, H.; Huster, K. M. Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines J. Immunol. 2005, 174, 4373-80
12. Wagner, H. The immunogenicity of CpG-antigen conjugates Adv. Drug Delivery Rev. 2009, 61, 243-7
13. Heit, A.; Schmitz, F.; Haas, T.; Busch, D. H.; Wagner, H. Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity Eur. J. Immunol. 2007, 37, 2063-74
14. Krishnamachari, Y.; Salem, A. K. Innovative strategies for co-delivering antigens and CpG oligonucleotides Adv. Drug Delivery Rev. 2009, 61, 205-17
15. Heit, A.; Huster, K. M.; Schmitz, F.; Schiemann, M.; Busch, D. H.; Wagner, H. CpG-DNA aided cross-priming by cross-presenting B cells J. Immunol. 2004, 172, 1501-7
16. Maurer, T.; Heit, A.; Hochrein, H.; Ampenberger, F.; O'Keeffe, M.; Bauer, S.; Lipford, G. B.; Vabulas, R. M.; Wagner, H. CpG-DNA aided cross-presentation of soluble antigens by dendritic cells Eur. J. Immunol. 2002, 32, 2356-64
17. Mandal, M.; Lee, K. D. Listeriolysin O-liposome-mediated cytosolic delivery of macromolecule antigen in vivo: enhancement of antigen-specific cytotoxic T lymphocyte frequency, activity, and tumor protection Biochim. Biophys. Acta 2002, 1563, 7-17
18. Mandal, M.; Kawamura, K. S.; Wherry, E. J.; Ahmed, R.; Lee, K. D. Cytosolic delivery of viral nucleoprotein by listeriolysin O-liposome induces enhanced specific cytotoxic T lymphocyte response and protective immunity Mol. Pharmaceutics 2004, 1, 2-8
19. Portnoy, D. A.; Jones, S. The cell biology of Listeria monocytogenes infection (escape from a vacuole) Ann. N.Y. Acad. Sci. 1994, 730, 15-25
20. Stier, E. M.; Mandal, M.; Lee, K. D. Differential cytosolic delivery and presentation of antigen by listeriolysin O-liposomes to macrophages and dendritic cells Mol. Pharmaceutics 2005, 2, 74-82
21. Mathew, E.; Hardee, G. E.; Bennett, C. F.; Lee, K. D. Cytosolic delivery of antisense oligonucleotides by listeriolysin O-containing liposomes Gene Ther. 2003, 10, 1105-15
22. Sanderson, S.; Shastri, N. LacZ inducible, antigen/MHC-specific T cell hybrids Int. Immunol. 1994, 6, 369-76
23. Klinman, D. M. Immunotherapeutic uses of CpG oligodeoxynucleotides Nat. Rev. Immunol. 2004, 4, 249-58
24. van Duin, D.; Medzhitov, R.; Shaw, A. C. Triggering TLR signaling in vaccination Trends Immunol. 2006, 27, 49-55
25. Krieg, A. M.; Davis, H. L. CpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines. In Vaccine Adjuvants; Hackett, C. J.; Harn, D. A., Jr., Eds.; Humana Press Inc.: Totowa, 2006; pp 87-110.
26. Klinman, D. M.; Klaschik, S.; Sato, T.; Tross, D. CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases Adv. Drug Delivery Rev. 2009, 61, 248-55
27. Barton, G. M.; Kagan, J. C.; Medzhitov, R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA Nat. Immunol. 2006, 7, 49-56
28. Campbell, J. D.; Cho, Y.; Foster, M. L.; Kanzler, H.; Kachura, M. A.; Lum, J. A.; Ratcliffe, M. J.; Sathe, A.; Leishman, A. J.; Bahl, A.; McHale, M.; Coffman, R. L.; Hessel, E. M. CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans J. Clin. Invest. 2009, 119, 2564-76
29. Chikh, G.; de Jong, S. D.; Sekirov, L.; Raney, S. G.; Kazem, M.; Wilson, K. D.; Cullis, P. R.; Dutz, J. P.; Tam, Y. K. Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles Int. Immunol. 2009, 21, 757-67
30. Barry, M.; Cooper, C. Review of hepatitis B surface antigen-1018 ISS adjuvant-containing vaccine safety and efficacy Expert Opin. Biol. Ther. 2007, 7, 1731-7