MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3

Journal of Neuro-Oncology

Volumn 122, Issue 3, 2015, Pages 431-439

  Liu, Huailei ^a,b   Li, Chenguang ^a,b   Shen, Chen ^a,b   Yin, Fei ^a,b   Wang, Kaikai ^a,b   Liu, Yaohua ^a,b   Zheng, Bingjie ^a,b   Zhang, Weiguang ^a,b   Hou, Xu ^a,b   Chen, Xin ^a,b   Wu, Jianing ^a,b   Wang, Xiaoxiong ^a,b   Zhong, Chen ^a,b   Zhang, Jiakang ^a,b   Shi, Huaizhang ^a   Ai, Jing ^b   Zhao, Shiguang ^a,b  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Glioblastoma; MiR 212 3p; Serum and glucocorticoid inducible kinase 3 (SGK3)

Indexed keywords

GREEN FLUORESCENT PROTEIN; MESSENGER RNA; MICRORNA; MIRN212 MICRORNA, HUMAN; PROTEIN SERINE THREONINE KINASE; SGK3 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL; BRAIN TUMOR; CELL PROLIFERATION; DRUG SCREENING; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GLIOBLASTOMA; HUMAN; MALE; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; PSYCHOLOGY; STATISTICAL MODEL; TUMOR CELL LINE;

ANIMALS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; GREEN FLUORESCENT PROTEINS; HUMANS; LINEAR MODELS; MALE; MICE; MICE, NUDE; MICRORNAS; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84939950086     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-015-1736-y     Document Type: Article

References (37)

1. Park JK, Hodges T, Arko L, Shen M, Iacono DD, McNabb A, Bailey NO, Kreisl TN, Iwamoto FM, Sul J, Auh S, Park GE, Fine HA, Black PM (2010) Scale to predict survival after surgery for recurrent glioblastoma multiforme. J Clin Oncol 28:3838–3843
2. Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359:492–507
3. Liu H, Han D, Liu Y, Hou X, Wu J, Li H, Yang J, Shen C, Yang G, Fu C, Li X, Che H, Ai J, Zhao S (2013) Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma. J Neurooncol 112:39–48
4. Zhao S, Liu H, Liu Y, Wu J, Wang C, Hou X, Chen X, Yang G, Zhao L, Che H, Bi Y, Wang H, Peng F, Ai J (2013) miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells. Cancer Lett 333:253–260
5. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL (1993) Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13:2031–2040
6. Liu M, Chen L, Chan TH, Wang J, Li Y, Li Y, Zeng TT, Yuan YF, Guan XY (2012) Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma. Hepatology 55:1754–1765
7. Tessier M, Woodgett JR (2006) Serum and glucocorticoid-regulated protein kinases: variations on a theme. J Cell Biochem 98:1391–1407
8. Chautard E, Ouedraogo ZG, Biau J, Verrelle P (2014) Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness. J Neurooncol 117:205–215
9. Bruhn MA, Pearson RB, Hannan RD, Sheppard KE (2013) AKT-independent PI3-K signaling in cancer—emerging role for SGK3. Cancer Manag Res 5:281–292
10. Wang Y, Zhou D, Phung S, Masri S, Smith D, Chen S (2011) SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol 25:72–82
11. Alonso L, Okada H, Pasolli HA, Wakeham A, You-Ten AI, Mak TW, Fuchs E (2005) Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle. J Cell Biol 170:559–570
12. Sinha S, Koul N, Dixit D, Sharma V, Sen E (2011) IGF-1 induced HIF-1alpha-TLR9 cross talk regulates inflammatory responses in glioma. Cell Signal 23:1869–1875
13. Cornez I, Joel M, Tasken K, Langmoen IA, Glover JC, Berge T (2013) EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry. J Neurooncol 112:49–57
14. Ling N, Gu J, Lei Z, Li M, Zhao J, Zhang HT, Li X (2013) microRNA-155 regulates cell proliferation and invasion by targeting FOXO3a in glioma. Oncol Rep 30:2111–2118
15. Kotliarova S, Pastorino S, Kovell LC, Kotliarov Y, Song H, Zhang W, Bailey R, Maric D, Zenklusen JC, Lee J, Fine HA (2008) Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res 68:6643–6651
16. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297
17. Ambros V (2004) The functions of animal microRNAs. Nature 431:350–355
18. Fan YC, Mei PJ, Chen C, Miao FA, Zhang H, Li ZL (2013) MiR-29c inhibits glioma cell proliferation, migration, invasion and angiogenesis. J Neurooncol 115:179–188
19. Zhao S, Deng Y, Liu Y, Chen X, Yang G, Mu Y, Zhang D, Kang J, Wu Z (2013) MicroRNA-153 is tumor suppressive in glioblastoma stem cells. Mol Biol Rep 40:2789–2798
20. Zhao S, Yang G, Mu Y, Han D, Shi C, Chen X, Deng Y, Zhang D, Wang L, Liu Y, Hou X, Wang C, Wu J, Liu H, Wang L, Zhang G, Qi J, Fang X, Shi C, Ai J (2013) MiR-106a is an independent prognostic marker in patients with glioblastoma. Neuro Oncol 15:707–717
21. Lawler S, Chiocca EA (2009) Emerging functions of microRNAs in glioblastoma. J Neurooncol 92:297–306
22. Incoronato M, Garofalo M, Urso L, Romano G, Quintavalle C, Zanca C, Iaboni M, Nuovo G, Croce CM, Condorelli G (2010) miR-212 increases tumor necrosis factor-related apoptosis-inducing ligand sensitivity in non-small cell lung cancer by targeting the antiapoptotic protein PED. Cancer Res 70:3638–3646
23. Jiping Z, Ming F, Lixiang W, Xiuming L, Yuqun S, Han Y, Zhifang L, Yundong S, Shili L, Chunyan C, Jihui J (2013) MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2. J Cell Biochem 114:2666–2672
24. Meng X, Wu J, Pan C, Wang H, Ying X, Zhou Y, Yu H, Zuo Y, Pan Z, Liu RY, Huang W (2013) Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology 145(426–436):e421–426
25. Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE, Hjelmeland AB, Rich JN (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15:501–513
26. Incoronato M, Urso L, Portela A, Laukkanen MO, Soini Y, Quintavalle C, Keller S, Esteller M, Condorelli G (2011) Epigenetic regulation of miR-212 expression in lung cancer. PLoS ONE 6:e27722
27. Xu L, Wang F, Xu XF, Mo WH, Xia YJ, Wan R, Wang XP, Guo CY (2011) Down-regulation of miR-212 expression by DNA hypermethylation in human gastric cancer cells. Med Oncol 28(Suppl 1):S189–196
28. Sun SM, Rockova V, Bullinger L, Dijkstra MK, Dohner H, Lowenberg B, Jongen-Lavrencic M (2013) The prognostic relevance of miR-212 expression with survival in cytogenetically and molecularly heterogeneous AML. Leukemia 27:100–106
29. Liang X, Zeng J, Wang L, Fang M, Wang Q, Zhao M, Xu X, Liu Z, Li W, Liu S, Yu H, Jia J, Chen C (2013) Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212. PLoS ONE 8:e69784
30. Wada R, Akiyama Y, Hashimoto Y, Fukamachi H, Yuasa Y (2010) miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int J Cancer 127:1106–1114
31. Park JK, Henry JC, Jiang J, Esau C, Gusev Y, Lerner MR, Postier RG, Brackett DJ, Schmittgen TD (2011) miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun 406:518–523
32. Li Y, Zhang D, Chen C, Ruan Z, Li Y, Huang Y (2012) MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1. Mol Biol Cell 23:1423–1434
33. Bruhn MA, Pearson RB, Hannan RD, Sheppard KE (2010) Second AKT: the rise of SGK in cancer signalling. Growth Factors 28:394–408
34. Wang Y, Xu W, Zhou D, Neckers L, Chen S (2014) Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex. J Biol Chem 289:4815–4826
35. McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D (2004) Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell 15:4278–4288
36. Gallia GL, Rand V, Siu IM, Eberhart CG, James CD, Marie SK, Oba-Shinjo SM, Carlotti CG, Caballero OL, Simpson AJ, Brock MV, Massion PP, Carson BS Sr, Riggins GJ (2006) PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res 4:709–714
37. Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA (2009) AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 16:21–32