메뉴 건너뛰기




Volumn 32, Issue 5, 2015, Pages 1615-1625

Alternating Magnetic Field-Induced Hyperthermia Increases Iron Oxide Nanoparticle Cell Association/Uptake and Flux in Blood-Brain Barrier Models

Author keywords

alternating magnetic field; blood brain barrier permeability; cross linked nanoassemblies; flux; superparamagnetic iron oxide nanoparticles

Indexed keywords

CITRIC ACID; FERRIC ION; FERRIC OXIDE; MAGNETITE NANOPARTICLE;

EID: 84939943704     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1561-6     Document Type: Article
Times cited : (59)

References (45)
  • 1
    • 57849124094 scopus 로고    scopus 로고
    • Physiology and pharmacological role of the blood-brain barrier
    • 1:CAS:528:DC%2BD1MXisFCgt7Y%3D 19066407
    • Bernacki J, Dobrowolska A, Nierwinska K, Malecki A. Physiology and pharmacological role of the blood-brain barrier. Pharmacol Rep. 2008;60(5):600-22.
    • (2008) Pharmacol Rep , vol.60 , Issue.5 , pp. 600-22
    • Bernacki, J.1    Dobrowolska, A.2    Nierwinska, K.3    Malecki, A.4
  • 2
  • 3
    • 46449107010 scopus 로고    scopus 로고
    • Biophysical characterization of nanoparticle-endothelial model cell membrane interactions
    • 1:CAS:528:DC%2BD1cXhvV2lsr4%3D 18271547
    • Peetla C, Labhasetwar V. Biophysical characterization of nanoparticle-endothelial model cell membrane interactions. Mol Pharm. 2008;5(3):418-29.
    • (2008) Mol Pharm , vol.5 , Issue.3 , pp. 418-29
    • Peetla, C.1    Labhasetwar, V.2
  • 4
    • 67649230473 scopus 로고    scopus 로고
    • On the mechanism and dynamics of uptake and permeation of polyether-copolyester dendrimers across an in vitro blood-brain barrier model
    • 1:CAS:528:DC%2BD1MXhtVKhsr%2FI 19156840
    • Dhanikula RS, Hammady T, Hildgen P. On the mechanism and dynamics of uptake and permeation of polyether-copolyester dendrimers across an in vitro blood-brain barrier model. J Pharm Sci. 2009;98(10):3748-60.
    • (2009) J Pharm Sci , vol.98 , Issue.10 , pp. 3748-60
    • Dhanikula, R.S.1    Hammady, T.2    Hildgen, P.3
  • 5
    • 84907051246 scopus 로고    scopus 로고
    • The hippocampal neurovascular niche during normal development and after irradiation to the juvenile mouse brain
    • 24913294
    • Boström M, Hellstroem Erkenstam N, Kaluza D, Jakobsson L, Kalm M, Blomgren K. The hippocampal neurovascular niche during normal development and after irradiation to the juvenile mouse brain. Int J Radiat Biol. 2014;90(9):778-89.
    • (2014) Int J Radiat Biol , vol.90 , Issue.9 , pp. 778-89
    • Boström, M.1    Hellstroem Erkenstam, N.2    Kaluza, D.3    Jakobsson, L.4    Kalm, M.5    Blomgren, K.6
  • 6
    • 0025295847 scopus 로고
    • Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins
    • 1:CAS:528:DyaK3cXksFGgt7Y%3D 2338547
    • Triguero D, Buciak J, Pardridge WM. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem. 1990;54(6):1882-8.
    • (1990) J Neurochem , vol.54 , Issue.6 , pp. 1882-8
    • Triguero, D.1    Buciak, J.2    Pardridge, W.M.3
  • 7
    • 80053384428 scopus 로고    scopus 로고
    • 2 particles exert size and surface coating dependent retention and lesions on the murine brain
    • 1:CAS:528:DC%2BC3MXht1KmsrrM 21855616
    • 2 particles exert size and surface coating dependent retention and lesions on the murine brain. Toxicol Lett. 2011;207(1):73-81.
    • (2011) Toxicol Lett , vol.207 , Issue.1 , pp. 73-81
    • Zhang, L.1    Bai, R.2    Li, B.3    Ge, C.4    Du, J.5    Liu, Y.6
  • 8
    • 56549115351 scopus 로고    scopus 로고
    • 2 nanoparticles in the anatase and rutile crystal phases
    • 1:CAS:528:DC%2BD1cXhsVCmsb7I 18992307
    • 2 nanoparticles in the anatase and rutile crystal phases. Toxicol Lett. 2008;183(1-3):72-80.
    • (2008) Toxicol Lett , vol.183 , Issue.1-3 , pp. 72-80
    • Wang, J.1    Chen, C.2    Liu, Y.3    Jiao, F.4    Li, W.5    Lao, F.6
  • 9
    • 33749025543 scopus 로고    scopus 로고
    • Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model
    • 1:CAS:528:DC%2BD28XhtFemu7rJ 16980278
    • Ambruosi A, Gelperina S, Khalansky A, Tanski S, Theisen A, Kreuter J. Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model. J Microencapsul. 2006;23(5):582-92.
    • (2006) J Microencapsul , vol.23 , Issue.5 , pp. 582-92
    • Ambruosi, A.1    Gelperina, S.2    Khalansky, A.3    Tanski, S.4    Theisen, A.5    Kreuter, J.6
  • 10
    • 84873434943 scopus 로고    scopus 로고
    • Block copolymer cross-linked nanoassemblies improve particle stability and biocompatibility of superparamagnetic iron oxide nanoparticles
    • 4076800 1:CAS:528:DC%2BC38XhsFantr3I 23080062
    • Dan M, Scott DF, Hardy PA, Wydra RJ, Hilt JZ, Yokel RA, et al. Block copolymer cross-linked nanoassemblies improve particle stability and biocompatibility of superparamagnetic iron oxide nanoparticles. Pharm Res. 2013;30(3):552-61.
    • (2013) Pharm Res , vol.30 , Issue.3 , pp. 552-61
    • Dan, M.1    Scott, D.F.2    Hardy, P.A.3    Wydra, R.J.4    Hilt, J.Z.5    Yokel, R.A.6
  • 11
    • 0036668656 scopus 로고    scopus 로고
    • Heating the patient: A promising approach?
    • 12181239
    • van der Zee J. Heating the patient: a promising approach? Ann Oncol. 2002;13(8):1173-84.
    • (2002) Ann Oncol , vol.13 , Issue.8 , pp. 1173-84
    • Van Der Zee, J.1
  • 12
    • 77954942987 scopus 로고    scopus 로고
    • Synthesis and characterization of thermoresponsive poly(ethylene glycol)-based hydrogels and their magnetic nanocomposites
    • 1:CAS:528:DC%2BC3cXotlWns70%3D
    • Meenach SA, Anderson KW, Hilt JZ. Synthesis and characterization of thermoresponsive poly(ethylene glycol)-based hydrogels and their magnetic nanocomposites. J Polym Sci Part A: Polym Chem. 2010;48(15):3229-35.
    • (2010) J Polym Sci Part A: Polym Chem , vol.48 , Issue.15 , pp. 3229-35
    • Meenach, S.A.1    Anderson, K.W.2    Hilt, J.Z.3
  • 13
    • 80053376590 scopus 로고    scopus 로고
    • Application of hyperthermia induced by superparamagnetic iron oxide nanoparticles in glioma treatment
    • 1:CAS:528:DC%2BC3MXksVOqtLo%3D
    • Silva AC, Oliveira TR, Mamani JB, Malheiros SMF, Malavolta L, Pavon LF, et al. Application of hyperthermia induced by superparamagnetic iron oxide nanoparticles in glioma treatment. Int J Nanomed. 2011;6:591-603.
    • (2011) Int J Nanomed , vol.6 , pp. 591-603
    • Silva, A.C.1    Oliveira, T.R.2    Mamani, J.B.3    Malheiros, S.M.F.4    Malavolta, L.5    Pavon, L.F.6
  • 14
    • 67349091117 scopus 로고    scopus 로고
    • Permeability of the blood-brain barrier depends on brain temperature
    • 1:CAS:528:DC%2BD1MXms1OmsbY%3D
    • Kiyatkin EA, Sharma HS. Permeability of the blood-brain barrier depends on brain temperature. Neuroscience (Amsterdam, Neth). 2009;161(3):926-39.
    • (2009) Neuroscience (Amsterdam, Neth) , vol.161 , Issue.3 , pp. 926-39
    • Kiyatkin, E.A.1    Sharma, H.S.2
  • 15
    • 79960320339 scopus 로고    scopus 로고
    • Improving efficiency of adriamycin crossing blood brain barrier by combination of thermosensitive liposomes and hyperthermia
    • 1:CAS:528:DC%2BC3MXhtFOjurzJ 21720013
    • Gong W, Wang Z, Liu N, Lin W, Wang X, Xu D, et al. Improving efficiency of adriamycin crossing blood brain barrier by combination of thermosensitive liposomes and hyperthermia. Biol Pharm Bull. 2011;34(7):1058-64.
    • (2011) Biol Pharm Bull , vol.34 , Issue.7 , pp. 1058-64
    • Gong, W.1    Wang, Z.2    Liu, N.3    Lin, W.4    Wang, X.5    Xu, D.6
  • 16
    • 0038376267 scopus 로고    scopus 로고
    • Hyperthermia induced pathophysiology of the central nervous system
    • 1:CAS:528:DC%2BD3sXktVGkt7s%3D 12745974
    • Sharma HS, Hoopes PJ. Hyperthermia induced pathophysiology of the central nervous system. Int J Hyperthermia. 2003;19(3):325-54.
    • (2003) Int J Hyperthermia , vol.19 , Issue.3 , pp. 325-54
    • Sharma, H.S.1    Hoopes, P.J.2
  • 17
    • 84555202693 scopus 로고    scopus 로고
    • Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells
    • 1:CAS:528:DC%2BC3MXhs1KqsL3E
    • Kenzaoui BH, Bernasconi CC, Hofmann H, Juillerat-Jeanneret L. Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells. Nanomedicine (Lond). 2012;7(1):39-53.
    • (2012) Nanomedicine (Lond) , vol.7 , Issue.1 , pp. 39-53
    • Kenzaoui, B.H.1    Bernasconi, C.C.2    Hofmann, H.3    Juillerat-Jeanneret, L.4
  • 18
    • 84875535969 scopus 로고    scopus 로고
    • Paracellular barrier and tight junction protein expression in the immortalized brain endothelial cell lines bEND.3, bEND.5 and mouse brain endothelial cell 4
    • 1:CAS:528:DC%2BC3sXntVClt7o%3D 23449334
    • Watanabe T, Dohgu S, Takata F, Nishioku T, Nakashima A, Futagami K, et al. Paracellular barrier and tight junction protein expression in the immortalized brain endothelial cell lines bEND.3, bEND.5 and mouse brain endothelial cell 4. Biol Pharm Bull. 2013;36(3):492-5.
    • (2013) Biol Pharm Bull , vol.36 , Issue.3 , pp. 492-5
    • Watanabe, T.1    Dohgu, S.2    Takata, F.3    Nishioku, T.4    Nakashima, A.5    Futagami, K.6
  • 19
    • 84855947240 scopus 로고    scopus 로고
    • An improved in vitro blood-brain barrier model: Rat brain endothelial cells co-cultured with astrocytes
    • Astrocytes: Methods & Protocols
    • Abbott NJ, Dolman DEM, Drndarski S, Fredriksson SM. An improved in vitro blood-brain barrier model: rat brain endothelial cells co-cultured with astrocytes. Methods Mol Biol (N Y, NY, U S). 2012;814(Astrocytes: Methods & Protocols):415-30.
    • (2012) Methods Mol Biol (N Y, NY, U S) , vol.814 , pp. 415-30
    • Abbott, N.J.1    Dolman, D.E.M.2    Drndarski, S.3    Fredriksson, S.M.4
  • 20
    • 84868572433 scopus 로고    scopus 로고
    • Pigmented-MDCK (P-MDCK) cell line with tunable melanin expression: An in vitro model for the outer blood-retinal barrier
    • 3926804 1:CAS:528:DC%2BC38Xhtl2nsLvO 23003570
    • Kadam RS, Scheinman RI, Kompella UB. Pigmented-MDCK (P-MDCK) cell line with tunable melanin expression: an in vitro model for the outer blood-retinal barrier. Mol Pharm. 2012;9(11):3228-35.
    • (2012) Mol Pharm , vol.9 , Issue.11 , pp. 3228-35
    • Kadam, R.S.1    Scheinman, R.I.2    Kompella, U.B.3
  • 22
    • 84867848663 scopus 로고    scopus 로고
    • Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models
    • 1:CAS:528:DC%2BC38XhtlCiur7F 22906709
    • Hellinger E, Veszelka S, Toth AE, Walter F, Kittel A, Bakk ML, et al. Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models. Eur J Pharm Biopharm. 2012;82(2):340-51.
    • (2012) Eur J Pharm Biopharm , vol.82 , Issue.2 , pp. 340-51
    • Hellinger, E.1    Veszelka, S.2    Toth, A.E.3    Walter, F.4    Kittel, A.5    Bakk, M.L.6
  • 23
    • 79960275482 scopus 로고    scopus 로고
    • Cross-linked nanoassemblies from poly(ethylene glycol)-poly(aspartate) block copolymers as stable supramolecular templates for particulate drug delivery
    • 1:CAS:528:DC%2BC3MXnsF2gt7k%3D 21644544
    • Lee HJ, Bae Y. Cross-linked nanoassemblies from poly(ethylene glycol)-poly(aspartate) block copolymers as stable supramolecular templates for particulate drug delivery. Biomacromolecules. 2011;12(7):2686-96.
    • (2011) Biomacromolecules , vol.12 , Issue.7 , pp. 2686-96
    • Lee, H.J.1    Bae, Y.2
  • 24
    • 33845966079 scopus 로고    scopus 로고
    • Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells
    • 1995120 1:CAS:528:DC%2BD2sXls1WqtA%3D%3D 17169347
    • Brown RC, Morris AP, O'Neil RG. Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells. Brain Res. 2007;1130(1):17-30.
    • (2007) Brain Res , vol.1130 , Issue.1 , pp. 17-30
    • Brown, R.C.1    Morris, A.P.2    O'Neil, R.G.3
  • 25
    • 78650456095 scopus 로고    scopus 로고
    • Assessment of macrolide transport using PAMPA, Caco-2 and MDCKII-hMDR1 assays
    • 1:CAS:528:DC%2BC3cXhs1art77F
    • Nozinic D, Milic A, Mikac L, Ralic J, Padovan J, Antolovic R. Assessment of macrolide transport using PAMPA, Caco-2 and MDCKII-hMDR1 assays. Croat Chem Acta. 2010;83(3):323-31.
    • (2010) Croat Chem Acta , vol.83 , Issue.3 , pp. 323-31
    • Nozinic, D.1    Milic, A.2    Mikac, L.3    Ralic, J.4    Padovan, J.5    Antolovic, R.6
  • 26
    • 84863011505 scopus 로고    scopus 로고
    • Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model
    • 1:CAS:528:DC%2BC38XitFyktL4%3D
    • Basel MT, Balivada S, Wang H, Shrestha TB, Seo GM, Pyle M, et al. Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model. Int J Nanomed. 2012;7:297-306.
    • (2012) Int J Nanomed , vol.7 , pp. 297-306
    • Basel, M.T.1    Balivada, S.2    Wang, H.3    Shrestha, T.B.4    Seo, G.M.5    Pyle, M.6
  • 27
    • 3242657100 scopus 로고    scopus 로고
    • Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells
    • 1:CAS:528:DC%2BD2cXlvVWju74%3D 15265744
    • Riemer J, Hoepken HH, Czerwinska H, Robinson SR, Dringen R. Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells. Anal Biochem. 2004;331(2):370-5.
    • (2004) Anal Biochem , vol.331 , Issue.2 , pp. 370-5
    • Riemer, J.1    Hoepken, H.H.2    Czerwinska, H.3    Robinson, S.R.4    Dringen, R.5
  • 29
    • 24044447605 scopus 로고    scopus 로고
    • The chemical species of aluminum influences its paracellular flux across and uptake into Caco-2 cells, a model of gastrointestinal absorption
    • 1:CAS:528:DC%2BD2MXovVOjs70%3D 15933224
    • Zhou Y, Yokel RA. The chemical species of aluminum influences its paracellular flux across and uptake into Caco-2 cells, a model of gastrointestinal absorption. Toxicol Sci. 2005;87(1):15-26.
    • (2005) Toxicol Sci , vol.87 , Issue.1 , pp. 15-26
    • Zhou, Y.1    Yokel, R.A.2
  • 30
    • 51149102710 scopus 로고    scopus 로고
    • Trypan blue exclusion test of cell viability
    • Coligan JE, editor. Appendix 3B
    • Strober W. Trypan blue exclusion test of cell viability. In: Coligan JE, editor. Curr Protoc Immunol. 2001; Appendix 3B.
    • (2001) Curr Protoc Immunol
    • Strober, W.1
  • 32
    • 18144377999 scopus 로고    scopus 로고
    • Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system
    • 1:CAS:528:DC%2BD2MXktVagsbo%3D
    • Neuberger T, Schoepf B, Hofmann H, Hofmann M, Von Rechenberg B. Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. J Magn Magn Mater. 2005;293(1):483-96.
    • (2005) J Magn Magn Mater , vol.293 , Issue.1 , pp. 483-96
    • Neuberger, T.1    Schoepf, B.2    Hofmann, H.3    Hofmann, M.4    Von Rechenberg, B.5
  • 33
    • 84858852448 scopus 로고    scopus 로고
    • Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity
    • 1:CAS:528:DC%2BC3MXhs1entL%2FL
    • Scott D, Rohr J, Bae Y. Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity. Int J Nanomed. 2011;6:2757-67.
    • (2011) Int J Nanomed , vol.6 , pp. 2757-67
    • Scott, D.1    Rohr, J.2    Bae, Y.3
  • 34
    • 84873974672 scopus 로고    scopus 로고
    • Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood-brain barrier
    • 1:CAS:528:DC%2BC3sXjt1ejsro%3D
    • Hoff D, Sheikh L, Bhattacharya S, Nayar S, Webster TJ. Comparison study of ferrofluid and powder iron oxide nanoparticle permeability across the blood-brain barrier. Int J Nanomed. 2012;8:703-10.
    • (2012) Int J Nanomed , vol.8 , pp. 703-10
    • Hoff, D.1    Sheikh, L.2    Bhattacharya, S.3    Nayar, S.4    Webster, T.J.5
  • 35
    • 84903317310 scopus 로고    scopus 로고
    • Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood-brain barrier
    • 1:CAS:528:DC%2BC2cXhvFKrsbnI
    • Sun Z, Worden M, Wroczynskyj Y, Yathindranath V, van Lierop J, Hegmann T, et al. Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood-brain barrier. Int J Nanomed. 2014;9:3013-26.
    • (2014) Int J Nanomed , vol.9 , pp. 3013-26
    • Sun, Z.1    Worden, M.2    Wroczynskyj, Y.3    Yathindranath, V.4    Van Lierop, J.5    Hegmann, T.6
  • 36
    • 0026099116 scopus 로고
    • Blood-brain barrier alteration after microwave-induced hyperthermia is purely a thermal effect: I. Temperature and power measurements
    • 1:STN:280:DyaK3M7kt1yksQ%3D%3D 1996445
    • Moriyama E, Salcman M, Broadwell RD. Blood-brain barrier alteration after microwave-induced hyperthermia is purely a thermal effect: I. Temperature and power measurements. Surg Neurol. 1991;35(3):177-82.
    • (1991) Surg Neurol , vol.35 , Issue.3 , pp. 177-82
    • Moriyama, E.1    Salcman, M.2    Broadwell, R.D.3
  • 37
    • 0028033840 scopus 로고
    • Acute effects of interstitial hyperthermia on normal monkey brain-magnetic resonance imaging appearance and effects on blood-brain barrier
    • 1:STN:280:DyaK2M7hsFyhug%3D%3D
    • Nakagawa M, Matsumoto K, Higashi H, Furuta T, Ohmoto T. Acute effects of interstitial hyperthermia on normal monkey brain-magnetic resonance imaging appearance and effects on blood-brain barrier. Neurol Med Chir (Tokyo). 1994;34(10):668-75.
    • (1994) Neurol Med Chir (Tokyo) , vol.34 , Issue.10 , pp. 668-75
    • Nakagawa, M.1    Matsumoto, K.2    Higashi, H.3    Furuta, T.4    Ohmoto, T.5
  • 38
    • 31544437442 scopus 로고    scopus 로고
    • Interstitial hyperthermia with intra-arterial injection of adriamycin for malignant glioma
    • discussion 23
    • Uzuka T, Takahashi H, Tanaka R. Interstitial hyperthermia with intra-arterial injection of adriamycin for malignant glioma. Neurol Med Chir (Tokyo). 2006;46(1):19-23. discussion 23.
    • (2006) Neurol Med Chir (Tokyo) , vol.46 , Issue.1 , pp. 19-23
    • Uzuka, T.1    Takahashi, H.2    Tanaka, R.3
  • 39
    • 11144249849 scopus 로고    scopus 로고
    • Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier
    • 1:CAS:528:DC%2BD2cXhtFGhurvE 15620875
    • Wang Q, Rager JD, Weinstein K, Kardos PS, Dobson GL, Li J, et al. Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier. Int J Pharm. 2005;288(2):349-59.
    • (2005) Int J Pharm , vol.288 , Issue.2 , pp. 349-59
    • Wang, Q.1    Rager, J.D.2    Weinstein, K.3    Kardos, P.S.4    Dobson, G.L.5    Li, J.6
  • 42
    • 77956443547 scopus 로고    scopus 로고
    • Remote control of ion channels and neurons through magnetic-field heating of nanoparticles
    • 1:CAS:528:DC%2BC3cXpvVSrurg%3D 20581833
    • Huang H, Delikanli S, Zeng H, Ferkey DM, Pralle A. Remote control of ion channels and neurons through magnetic-field heating of nanoparticles. Nat Nanotechnol. 2010;5(8):602-6.
    • (2010) Nat Nanotechnol , vol.5 , Issue.8 , pp. 602-6
    • Huang, H.1    Delikanli, S.2    Zeng, H.3    Ferkey, D.M.4    Pralle, A.5
  • 43
    • 84862846766 scopus 로고    scopus 로고
    • Neuroprotective effects of cerebrolysin, a combination of different active fragments of neurotrophic factors and peptides on the whole body hyperthermia-induced neurotoxicity: Modulatory roles of co-morbidity factors and nanoparticle intoxication
    • New Perspectives of Central Nervous System Injury and Neuroprotection 1:CAS:528:DC%2BC38XhslCgurfI 22748833
    • Sharma HS, Sharma A, Moessler H, Muresanu DF. Neuroprotective effects of cerebrolysin, a combination of different active fragments of neurotrophic factors and peptides on the whole body hyperthermia-induced neurotoxicity: modulatory roles of co-morbidity factors and nanoparticle intoxication. Int Rev Neurobiol. 2012;102(New Perspectives of Central Nervous System Injury and Neuroprotection):249-76.
    • (2012) Int Rev Neurobiol , vol.102 , pp. 249-76
    • Sharma, H.S.1    Sharma, A.2    Moessler, H.3    Muresanu, D.F.4
  • 44
    • 84857116562 scopus 로고    scopus 로고
    • Nanowired drug delivery for neuroprotection in central nervous system injuries: Modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors
    • 1:CAS:528:DC%2BC38XltV2mtb4%3D 22162425
    • Sharma HS, Sharma A. Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012;4(2):184-203.
    • (2012) Wiley Interdiscip Rev Nanomed Nanobiotechnol , vol.4 , Issue.2 , pp. 184-203
    • Sharma, H.S.1    Sharma, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.