4-Hydroxy-trans-2-nonenal (4-HNE) induces neuronal SH-SY5Y cell death via hampering ATP binding at kinase domain of Akt1

Archives of Toxicology

Volumn 89, Issue 2, 2015, Pages 243-258

  Kashyap, Mahendra P ^a,b   Singh, Abhishek K ^a,c   Yadav, Dharmendra K ^d   Siddiqui, Maqsood A ^e   Srivastava, Ritesh K ^f   Chaturvedi, Vishal ^g   Rai, Navneet ^h  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c GURU GHASIDAS UNIVERSITY   (India)

^d Hanyang University   (South Korea)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^g CURTIN UNIVERSITY   (Australia)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

4 HNE; Akt Pkb; Apoptosis; Molecular modeling; Neuronal SH SY5Y Cells

Indexed keywords

4-HYDROXY-2-NONENAL; ADENOSINE TRIPHOSPHATE; ALDEHYDE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; BINDING SITE; DRUG EFFECTS; HUMAN; HYDROGEN BOND; METABOLISM; MOLECULAR DOCKING; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; ALDEHYDES; APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES;

EID: 84939893215     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1260-4     Document Type: Article

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