Caspase cascade regulated mitochondria mediated apoptosis in monocrotophos exposed PC12 cells

Chemical Research in Toxicology

Volumn 23, Issue 11, 2010, Pages 1663-1672

  Kashyap, M P ^a   Singh, A K ^a   Siddiqui, M A ^a,c   Kumar, V ^a   Tripathi, V K ^a   Khanna, V K ^a   Yadav, S ^a   Jain, S K ^b   Pant, A B ^a  

^a Indian Institute of Toxicological Research   (India)

^b HAMDARD UNIVERSITY   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 9; CYTOCHROME C; DNA; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIPID PEROXIDASE; MESSENGER RNA; MONOCROTOPHOS; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN MCL 1; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVITY; GENE TRANSLOCATION; LIPID PEROXIDATION; LONG TERM EXPOSURE; MEMBRANE PERMEABILITY; MICRONUCLEUS; MITOCHONDRION; NERVE CELL; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REACTOR CASCADE; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL MEMBRANE PERMEABILITY; CYTOCHROMES C; INSECTICIDES; LIPID PEROXIDATION; MITOCHONDRIA; MONOCROTOPHOS; PC12 CELLS; RATS; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78649280963     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100234m     Document Type: Article

References (75)

1. Steerenberg, P., van Amelsvoort, L., Colosio, C., Corsini, E., Fustinoni, S., Vergieva, T., Zaikov, C., Pennanen, S., Liesivuori, J., and Van Loveren, H. (2008) Toxicological evaluation of the immune function of pesticide workers, a European wide assessment Hum. Exp. Toxicol. 27, 701-707
2. Li, Q., Kobayashi, M., and Kawada, T. (2009) Chlorpyrifos induces apoptosis in human T cells Toxicology 255, 53-57
3. Costa, L. G. (2006) Current issues in organophosphate toxicology Clin. Chim. Acta 366, 1-13
4. Perera, P. M., Jayamanna, S. F., Hettiarachchi, R., Abeysinghe, C., Karunatilake, H., Dawson, A. H., and Buckley, N. A. (2009) A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning Trials 10, 73
5. Montgomery, M. P., Kamel, F., Saldana, T. M., Alavanja, M. C., and Sandler, D. P. (2008) Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health Study, 1993-2003 Am. J. Epidemiol. 167, 1235-1246
6. Andreotti, G., Freeman, L. E., Hou, L., Coble, J., Rusiecki, J., Hoppin, J. A., Silverman, D. T., and Alavanja, M. C. (2009) Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort Int. J. Cancer 124, 2495-2500
7. Mills, K. T., Blair, A., Freeman, L. E., Sandler, D. P., and Hoppin, J. A. (2009) Pesticides and myocardial infarction incidence and mortality among male pesticide applicators in the agricultural health study Am. J. Epidemiol. 170, 892-900
8. Dassanayake, T., Gawarammana, I. B., Weerasinghe, V., Dissanayake, P. S., Pragaash, S., Dawson, A., and Senanayake, N. (2009) Auditory event-related potential changes in chronic occupational exposure to organophosphate pesticides Clin. Neurophysiol. 120, 1693-1698
9. Shenouda, J., Green, P., and Sultatos, L. (2009) An Evaluation of the inhibition of human butyrylcholinesterase and acetylcholinesterase by the organophosphate chlorpyrifos oxon Toxicol. Appl. Pharmacol. 241, 135-142
10. Aurbek, N., Thiermann, H., Szinicz, L., Eyer, P., and Worek, F. (2006) Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase Toxicology 224, 91-99
11. Sarabia, L., Maurer, I., and Bustos-Obregon, E. (2009) Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on the mouse testis Ecotoxicol. Environ. Saf. 72, 938-942
12. Poovala, V. S., Huang, H., and Salahudeen, A. K. (1999) Role of reactive oxygen metabolites in organophosphate-bidrin-induced renal tubular cytotoxicity J. Am. Soc. Nephrol. 10, 1746-1752 (Pubitemid 29364673)
13. Chan, J. Y., Chan, S. H., Dai, K. Y., Cheng, H. L., Chou, J. L., and Chang, A. Y. (2006) Cholinergic-receptor-independent dysfunction of mitochondrial respiratory chain enzymes, reduced mitochondrial transmembrane potential and ATP depletion underlie necrotic cell death induced by the organophosphate poison mevinphos Neuropharmacology 51, 1109-1119
14. Saulsbury, M. D., Heyliger, S. O., Wang, K., and Round, D. (2008) Characterization of chlorpyrifos-induced apoptosis in placental cells Toxicology 244, 98-110
15. Moore, P. D., Yedjou, C. G., and Tchounwou, P. B. (2009) Malathion-induced oxidative stress, cytotoxicity, and genotoxicity in human liver carcinoma (HepG(2)) cells Environ. Toxicol. 25, 221-226
16. Giordano, G., Afsharinejad, Z., Guizzetti, M., Vitalone, A., Kavanagh, T. J., and Costa, L. G. (2007) Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency Toxicol. Appl. Pharmacol. 219, 181-189
17. Slotkin, T. A. and Seidler, F. J. (2009) Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells Environ. Health Perspect. 117, 587-596
18. Roegge, C. S., Timofeeva, O. A., Seidler, F. J., Slotkin, T. A., and Levin, E. D. (2008) Developmental diazinon neurotoxicity in rats: later effects on emotional response Brain Res. Bull. 75, 166-172
19. Veronesi, B. and Ehrich, M. (1993) Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides Toxicol. Appl. Pharmacol. 120, 240-246
20. Romero-Navarro, G., Lopez-Aceves, T., Rojas-Ochoa, A., and Fernandez Mejia, C. (2006) Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels Life Sci. 78, 1015-1020
21. Sachana, M., Flaskos, J., Alexaki, E., Glynn, P., and Hargreaves, A. J. (2001) The toxicity of chlorpyrifos towards differentiating mouse N2a neuroblastoma cells Toxicol. in Vitro 15, 369-372
22. Yang, Q. H., Church-Hajduk, R., Ren, J., Newton, M. L., and Du, C. (2003) Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis Genes Dev. 17, 1487-1496
23. Jin, H. O., Park, I. C., An, S., Lee, H. C., Woo, S. H., Hong, Y. J., Lee, S. J., Park, M. J., Yoo, D. H., Rhee, C. H., and Hong, S. I. (2006) Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells J. Cell Physiol. 206, 477-486
24. Kuan, C. Y., Whitmarsh, A. J., Yang, D. D., Liao, G., Schloemer, A. J., Dong, C., Bao, J., Banasiak, K. J., Haddad, G. G., Flavell, R. A., Davis, R. J., and Rakic, P. (2003) A critical role of neural-specific JNK3 for ischemic apoptosis Proc. Natl. Acad. Sci. U.S.A. 100, 15184-15189
25. Endo, H., Kamada, H., Nito, C., Nishi, T., and Chan, P. H. (2006) Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats J. Neurosci. 26, 7974-7983
26. Singh, S., Ranjit, A., Parthasarathy, S., Sharma, N., and Bambery, P. (2004) Organo-phosphate induced delayed neuropathy: report of two cases Neurol. India 52, 525-526
27. Singh, M., Sandhir, R., and Kiran, R. (2004) In vitro effects of organophosphate pesticides on rat erythrocytes Indian J. Exp. Biol. 42, 292-296
28. Masoud, A., Kiran, R., and Sandhir, R. (2009) Impaired mitochondrial functions in organophosphate induced delayed neuropathy in rats Cell Mol. Neurobiol. 29, 1245-1255
29. Zhao, M., Zhang, Y., Wang, C., Fu, Z., Liu, W., and Gan, J. (2009) Induction of macrophage apoptosis by an organochlorine insecticide acetofenate Chem. Res. Toxicol. 22, 504-510
30. Lepsch, L. B., Munhoz, C. D., Kawamoto, E. M., Yshii, L. M., Lima, L. S., Curi-Boaventura, M. F., Salgado, T. M., Curi, R., Planeta, C. S., and Scavone, C. (2009) Cocaine induces cell death and activates the transcription nuclear factor kappa-b in pc12 cells Mol. Brain 2, 3
31. Sarid, R., Ben-Moshe, T., Kazimirsky, G., Weisberg, S., Appel, E., Kobiler, D., Lustig, S., and Brodie, C. (2001) vFLIP protects PC-12 cells from apoptosis induced by Sindbis virus: implications for the role of TNF-alpha Cell Death Differ. 8, 1224-1231
32. Li, Y. and Maret, W. (2009) Transient fluctuations of intracellular zinc ions in cell proliferation Exp. Cell Res. 315, 2463-2470
33. Pant, A. B., Agarwal, A. K., Sharma, V. P., and Seth, P. K. (2001) In vitro cytotoxicity evaluation of plastic biomedical devices Hum. Exp. Toxicol. 20, 412-417
34. Siddiqui, M. A., Singh, G., Kashyap, M. P., Khanna, V. K., Yadav, S., Chandra, D., and Pant, A. B. (2008) Influence of cytotoxic doses of 4-hydroxynonenal on selected neurotransmitter receptors in PC-12 cells Toxicol. in Vitro 22, 1681-1688
35. Halliwell, B. and Whiteman, M. (2004) Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br. J. Pharmacol. 142, 231-255
36. Srivastava, R. K., Lohani, M., Pant, A. B., and Rahman, Q. (2010) Cyto-genotoxicity of amphibole asbestos fibers in cultured human lung epithelial cell line: Role of surface iron. Toxicol. Ind. Health. [Online early access], DOI: 10.1177/0748233710374464.
37. Schagger, H. (2006) Tricine-SDS-PAGE Nat. Protoc. 1, 16-22
38. Ghosh, S., Patel, N., Rahn, D., McAllister, J., Sadeghi, S., Horwitz, G., Berry, D., Wang, K. X., and Swerdlow, R. H. (2007) The thiazolidinedione pioglitazone alters mitochondrial function in human neuron-like cells Mol. Pharmacol. 71, 1695-1702
39. Waterhouse, N. J., Steel, R., Kluck, R., and Trapani, J. A. (2004) Assaying cytochrome C translocation during apoptosis Methods Mol. Biol. 284, 307-313
40. Fotakis, G. and Timbrell, J. A. (2006) In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride Toxicol. Lett. 160, 171-177
41. Das, P. P., Shaik, A. P., and Jamil, K. (2007) Genotoxicity induced by pesticide mixtures: in-vitro studies on human peripheral blood lymphocytes Toxicol. Ind. Health 23, 449-458
42. Benjamin, N., Kushwah, A., Sharma, R. K., and Katiyar, A. K. (2006) Histopathological changes in liver, kidney and muscles of pesticides exposed malnourished and diabetic rats Indian J. Exp. Biol. 44, 228-232
43. Wang, S., Yan-Neale, Y., Cai, R., Alimov, I., and Cohen, D. (2006) Activation of mitochondrial pathway is crucial for tumor selective induction of apoptosis by LAQ824 Cell Cycle 5, 1662-1668
44. Aschner, M., Allen, J. W., Kimelberg, H. K., LoPachin, R. M., and Streit, W. J. (1999) Glial cells in neurotoxicity development Annu. Rev. Pharmacol. Toxicol. 39, 151-173
45. Rossi, D. J., Brady, J. D., and Mohr, C. (2007) Astrocyte metabolism and signaling during brain ischemia Nat. Neurosci. 10, 1377-1386
46. Kroemer, G., Galluzzi, L., and Brenner, C. (2007) Mitochondrial membrane permeabilization in cell death Physiol. Rev. 87, 99-163 (Pubitemid 46209992)
47. Zhang, J., Hu, J., Ding, J. H., Yao, H. H., and Hu, G. (2005) 6-Hydroxydopamine-induced glutathione alteration occurs via glutathione enzyme system in primary cultured astrocytes Acta Pharmacol. Sin. 26, 799-805
48. Slotkin, T. A., MacKillop, E. A., Ryde, I. T., Tate, C. A., and Seidler, F. J. (2007) Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel Environ. Health Perspect. 115, 93-101
49. Slotkin, T. A. and Seidler, F. J. (2007) Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems Brain Res. Bull. 72, 232-274
50. Gonzalez-Santiago, L., Suarez, Y., Zarich, N., Munoz-Alonso, M. J., Cuadrado, A., Martinez, T., Goya, L., Iradi, A., Saez-Tormo, G., Maier, J. V., Moorthy, A., Cato, A. C., Rojas, J. M., and Munoz, A. (2006) Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation Cell Death Differ. 13, 1968-1981
51. Sun, F., Anantharam, V., Latchoumycandane, C., Kanthasamy, A., and Kanthasamy, A. G. (2005) Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death J. Pharmacol. Exp. Ther. 315, 69-79
52. Perez-Maldonado, I. N., Herrera, C., Batres, L. E., Gonzalez-Amaro, R., Diaz-Barriga, F., and Yanez, L. (2005) DDT-induced oxidative damage in human blood mononuclear cells Environ. Res. 98, 177-184
53. Huk, O. L., Catelas, I., Mwale, F., Antoniou, J., Zukor, D. J., and Petit, A. (2004) Induction of apoptosis and necrosis by metal ions in vitro J. Arthroplasty 19, 84-87
54. Saini, K. S., Thompson, C., Winterford, C. M., Walker, N. I., and Cameron, D. P. (1996) Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic beta cell line, INS-1 Biochem Mol. Biol. Int. 39, 1229-1236
55. Evans, R. and Cidlowski, J. (1995) Apoptosis: Cellular Signaling and Molecular Mechanisms, in Cell Biology of Trauma (Lemasters, J. and Oliver, C., Eds.) pp 25 - 47, CRC Press, Boca Raton, FL.
56. Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W., and Schulte-Hermann, R. (1995) In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionarynote Hepatology 21, 1465-1468
57. Charriaut-Marlangue, C. and Ben-Ari, Y. (1995) A cautionary note on the use of the TUNEL stain to determine apoptosis NeuroReport 7, 61-64
58. Galluzzi, L., Blomgren, K., and Kroemer, G. (2009) Mitochondrial membrane permeabilization in neuronal injury Nat. Rev. Neurosci. 10, 481-494
59. Segui, B. and Legembre, P. (2010) Redistribution of CD95 into the lipid rafts to treat cancer cells Recent Pat. Anti-Cancer Drug Discovery 5, 22-8
60. Poplawski, T., Pawlowska, E., Wisniewska-Jarosinska, M., Ksiazek, D., Wozniak, K., Szczepanska, J., and Blasiak, J. (2009) Cytotoxicity and genotoxicity of glycidyl methacrylate Chem.-Biol. Interact. 180, 69-78
61. Namazi, M. (2009) Cytochrome-P450 enzymes and autoimmunity: expansion of the relationship and introduction of free radicals as the link J. Autoimmune Dis. 6, 4
62. Galluzzi, L., Morselli, E., Kepp, O., Tajeddine, N., and Kroemer, G. (2008) Targeting p53 to mitochondria for cancer therapy Cell Cycle 7, 1949-1955
63. Carlson, K., Jortner, B. S., and Ehrich, M. (2000) Organophosphorus compound-induced apoptosis in SH-SY5Y human neuroblastoma cells Toxicol. Appl. Pharmacol. 168, 102-113
64. Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., and Vogelstein, B. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage Science 282, 1497-1501
65. Bargonetti, J. and Manfredi, J. J. (2002) Multiple roles of the tumor suppressor p53 Curr. Opin. Oncol. 14, 86-91
66. Cui, Q., Yu, J. H., Wu, J. N., Tashiro, S., Onodera, S., Minami, M., and Ikejima, T. (2007) P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells Acta Pharmacol. Sin. 28, 1057-1066
67. Moll, U. M., Wolff, S., Speidel, D., and Deppert, W. (2005) Transcription-independent pro-apoptotic functions of p53 Curr. Opin. Cell Biol. 17, 631-636
68. Yu, J. and Zhang, L. (2005) The transcriptional targets of p53 in apoptosis control Biochem. Biophys. Res. Commun. 331, 851-858
69. Saleh, A. M., Vijayasarathy, C., Masoud, L., Kumar, L., Shahin, A., and Kambal, A. (2003) Paraoxon induces apoptosis in EL4 cells via activation of mitochondrial pathways Toxicol. Appl. Pharmacol. 190, 47-57
70. Dejean, L. M., Martinez-Caballero, S., Guo, L., Hughes, C., Teijido, O., Ducret, T., Ichas, F., Korsmeyer, S. J., Antonsson, B., Jonas, E. A., and Kinnally, K. W. (2005) Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel Mol. Biol. Cell 16, 2424-2432
71. Wang, P., Yu, J., and Zhang, L. (2007) The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage Proc. Natl. Acad. Sci. U.S.A. 104, 4054-4059
72. Suzuki, Y., Takahashi-Niki, K., Akagi, T., Hashikawa, T., and Takahashi, R. (2004) Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways Cell Death Differ. 11, 208-216
73. Deng, Y., Lin, Y., and Wu, X. (2002) TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO Genes Dev. 16, 33-45
74. Wang, X., Zhu, C., Hagberg, H., Korhonen, L., Sandberg, M., Lindholm, D., and Blomgren, K. (2004) X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia Neurobiol. Dis. 16, 179-189
75. Raza, H. and John, A. (2006) 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells Toxicol. Appl. Pharmacol. 216, 309-318