Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis

Gastroenterology

Volumn 149, Issue 3, 2015, Pages 765e10-776.e10

  Sendler, Matthias ^a   Beyer, Georg ^a   Mahajan, Ujjwal M ^a   Kauschke, Vivien ^a   Maertin, Sandrina ^a   Schurmann, Claudia ^a   Homuth, Georg ^a   Völker, Uwe ^a   Völzke, Henry ^a   Halangk, Walter ^b   Wartmann, Thomas ^b   Weiss, Frank Ulrich ^a   Hegyi, Peter ^c   Lerch, Markus M ^a   Mayerle, Julia ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Complement System; Pancreatic Stellate Cells; Transcriptome Analysis; SMA

Indexed keywords

CERULETIDE; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5 INHIBITOR; COMPLEMENT COMPONENT C5A RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; C5AR1 PROTEIN, MOUSE; COMPLEMENT COMPONENT C5A RECEPTOR; N-((4-DIMETHYLAMINOPHENYL)METHYL)-N-(4-ISOPROPYLPHENYL)-7-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-CARBOXAMIDE; TETRALIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CHRONIC PANCREATITIS; COMMON BILE DUCT; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROSIS; GENE PRODUCT; GENETIC ASSOCIATION; GENOTYPE; IN VITRO STUDY; MOUSE; MOUSE MODEL; NONHUMAN; PANCREATIC STELLATE CELL; PRIMARY CELL CULTURE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CASE CONTROL STUDY; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LIGATION; METABOLISM; PANCREATIC DUCT; PANCREATITIS, CHRONIC; PATHOLOGY; PHENOTYPE; SURGERY; TIME FACTOR;

ANILINE COMPOUNDS; ANIMALS; CASE-CONTROL STUDIES; CERULETIDE; COMPLEMENT C5; DISEASE MODELS, ANIMAL; FIBROSIS; GENETIC PREDISPOSITION TO DISEASE; LIGATION; MICE, INBRED C57BL; MICE, KNOCKOUT; PANCREATIC DUCTS; PANCREATIC STELLATE CELLS; PANCREATITIS, CHRONIC; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ANAPHYLATOXIN C5A; TETRAHYDRONAPHTHALENES; TIME FACTORS;

EID: 84939865271     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.05.012     Document Type: Article

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