Synthetic Proteins Potently and Selectively Bind the Oncoprotein Gankyrin, Modulate Its Interaction with S6 ATPase, and Suppress Gankyrin/MDM2-Dependent Ubiquitination of p53

ACS Chemical Biology

Volumn 10, Issue 8, 2015, Pages 1880-1886

  Chapman, Alex M ^a   McNaughton, Brian R ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BINDING PROTEIN; GANKYRIN; GANKYRIN BINDING PROTEIN; ONCOPROTEIN; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG; ANKYRIN; PROTEASOME; PROTEIN; PROTEIN BINDING; PSMD10 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CELL LYSATE; CONTROLLED STUDY; DNA SHUFFLING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; THERMODYNAMICS; UBIQUITINATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR MODEL; MOUSE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANKYRIN REPEAT; HUMANS; MICE; MODELS, MOLECULAR; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN INTERACTION MAPS; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 84939864331     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00201     Document Type: Article

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