-
1
-
-
0034331004
-
Chemical genetics: Ligand-based discovery of gene function
-
Stockwell, B. R. (2000) Chemical genetics: ligand-based discovery of gene function. Nat. Rev. Genet. 1, 116-125.
-
(2000)
Nat. Rev. Genet.
, vol.1
, pp. 116-125
-
-
Stockwell, B.R.1
-
2
-
-
0034332931
-
Frontiers in chemical genetics
-
Stockwell, B. R. (2000) Frontiers in chemical genetics. Trends Biotechnol. 18, 449-455.
-
(2000)
Trends Biotechnol.
, vol.18
, pp. 449-455
-
-
Stockwell, B.R.1
-
3
-
-
33751547539
-
How many drug targets are there?
-
Overington, J. P., Al-Lazikani, B., and Hopkins, A. L. (2006) How many drug targets are there? Nat. Rev. Drug Discovery 5, 993-996.
-
(2006)
Nat. Rev. Drug Discovery
, vol.5
, pp. 993-996
-
-
Overington, J.P.1
Al-Lazikani, B.2
Hopkins, A.L.3
-
4
-
-
33845934490
-
Ankyrin repeat: A unique motif mediating protein-protein interactions
-
Li, J., Mahajan, A., and Tsai, M. D. (2006) Ankyrin repeat: a unique motif mediating protein-protein interactions. Biochemistry 45, 15168-15178.
-
(2006)
Biochemistry
, vol.45
, pp. 15168-15178
-
-
Li, J.1
Mahajan, A.2
Tsai, M.D.3
-
5
-
-
84874471740
-
Gankyrin is frequently overexpressed in breast cancer and is associated with ErbB2 expression
-
Kim, Y. H., Kim, J. H., Choi, Y. W., Lim, S. K., Yim, H., Kang, S. Y., Chung, Y. S., Lee, G. Y., and Park, T. J. (2013) Gankyrin is frequently overexpressed in breast cancer and is associated with ErbB2 expression. Exp. Mol. Pathol. 94, 360-365.
-
(2013)
Exp. Mol. Pathol.
, vol.94
, pp. 360-365
-
-
Kim, Y.H.1
Kim, J.H.2
Choi, Y.W.3
Lim, S.K.4
Yim, H.5
Kang, S.Y.6
Chung, Y.S.7
Lee, G.Y.8
Park, T.J.9
-
6
-
-
84880919355
-
Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activity
-
Zhen, C., Chen, L., Zhao, Q., Liang, B., Gu, Y. X., Bai, Z. F., Wang, K., Xu, X., Han, Q. Y., Fang, D. F., Wang, S. X., Zhou, T., Xia, Q., Gong, W. L., Wang, N., Li, H. Y., Jin, B. F., and Man, J. H. (2013) Gankyrin promotes breast cancer cell metastasis by regulating Rac1 activity. Oncogene 32, 3452-3460.
-
(2013)
Oncogene
, vol.32
, pp. 3452-3460
-
-
Zhen, C.1
Chen, L.2
Zhao, Q.3
Liang, B.4
Gu, Y.X.5
Bai, Z.F.6
Wang, K.7
Xu, X.8
Han, Q.Y.9
Fang, D.F.10
Wang, S.X.11
Zhou, T.12
Xia, Q.13
Gong, W.L.14
Wang, N.15
Li, H.Y.16
Jin, B.F.17
Man, J.H.18
-
7
-
-
0036678085
-
Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance
-
Fu, X. Y., Wang, H. Y., Tan, L., Liu, S. Q., Cao, H. F., and Wu, M. C. (2002) Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance. World J. Gastroenterol. 8, 638-643.
-
(2002)
World J. Gastroenterol.
, vol.8
, pp. 638-643
-
-
Fu, X.Y.1
Wang, H.Y.2
Tan, L.3
Liu, S.Q.4
Cao, H.F.5
Wu, M.C.6
-
8
-
-
79959434779
-
Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer
-
Li, J., Knobloch, T. J., Kresty, L. A., Zhang, Z., Lang, J. C., Schuller, D. E., and Weghorst, C. M. (2011) Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer. Anticancer Res. 31, 2683-2692.
-
(2011)
Anticancer Res.
, vol.31
, pp. 2683-2692
-
-
Li, J.1
Knobloch, T.J.2
Kresty, L.A.3
Zhang, Z.4
Lang, J.C.5
Schuller, D.E.6
Weghorst, C.M.7
-
9
-
-
77956230794
-
Gankyrin promotes the proliferation of human pancreatic cancer
-
Meng, Y., He, L., Guo, X., Tang, S., Zhao, X., Du, R., Jin, J., Bi, Q., Li, H., Nie, Y., Liu, J., and Fan, D. (2010) Gankyrin promotes the proliferation of human pancreatic cancer. Cancer Lett. 297, 9-17.
-
(2010)
Cancer Lett.
, vol.297
, pp. 9-17
-
-
Meng, Y.1
He, L.2
Guo, X.3
Tang, S.4
Zhao, X.5
Du, R.6
Jin, J.7
Bi, Q.8
Li, H.9
Nie, Y.10
Liu, J.11
Fan, D.12
-
10
-
-
85046915363
-
Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer
-
Tang, S., Yang, G., Meng, Y., Du, R., Li, X., Fan, R., Zhao, L., Bi, Q., Jin, J., Gao, L., Zhang, L., Li, H., Fan, M., Wang, Y., Wu, K., Liu, J., and Fan, D. (2010) Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer. Cancer Biol. Ther. 9, 88-95.
-
(2010)
Cancer Biol. Ther.
, vol.9
, pp. 88-95
-
-
Tang, S.1
Yang, G.2
Meng, Y.3
Du, R.4
Li, X.5
Fan, R.6
Zhao, L.7
Bi, Q.8
Jin, J.9
Gao, L.10
Zhang, L.11
Li, H.12
Fan, M.13
Wang, Y.14
Wu, K.15
Liu, J.16
Fan, D.17
-
11
-
-
36849040707
-
Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance
-
Ortiz, C. M., Ito, T., Tanaka, E., Tsunoda, S., Nagayama, S., Sakai, Y., Higashitsuji, H., Fujita, J., and Shimada, Y. (2008) Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance. Int. J. Cancer 122, 325-332.
-
(2008)
Int. J. Cancer
, vol.122
, pp. 325-332
-
-
Ortiz, C.M.1
Ito, T.2
Tanaka, E.3
Tsunoda, S.4
Nagayama, S.5
Sakai, Y.6
Higashitsuji, H.7
Fujita, J.8
Shimada, Y.9
-
12
-
-
77955285597
-
Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells
-
Man, J. H., Liang, B., Gu, Y. X., Zhou, T., Li, A. L., Li, T., Jin, B. F., Bai, B., Zhang, H. Y., Zhang, W. N., Li, W. H., Gong, W. L., Li, H. Y., and Zhang, X. M. (2010) Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells. J. Clin. Invest. 120, 2829-2841.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2829-2841
-
-
Man, J.H.1
Liang, B.2
Gu, Y.X.3
Zhou, T.4
Li, A.L.5
Li, T.6
Jin, B.F.7
Bai, B.8
Zhang, H.Y.9
Zhang, W.N.10
Li, W.H.11
Gong, W.L.12
Li, H.Y.13
Zhang, X.M.14
-
13
-
-
0037177225
-
Novel insights into the INK4-CDK4/6-Rb pathway: Counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb
-
Li, J. N., and Tsai, M. D. (2002) Novel insights into the INK4-CDK4/6-Rb pathway: Counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb. Biochemistry 41, 3977-3983.
-
(2002)
Biochemistry
, vol.41
, pp. 3977-3983
-
-
Li, J.N.1
Tsai, M.D.2
-
14
-
-
22244486994
-
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53 (vol 8, pg 75, 2005)
-
Higashitsuji, H., Higashitsuji, H., Itoh, K., Sakurai, T., Nagao, T., Sumitomo, Y., Masuda, T., Dawson, S., Shimada, Y., Mayer, R. J., and Fujita, J. (2005) The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53 (vol 8, pg 75, 2005). Cancer Cell No. 8, 169-169.
-
(2005)
Cancer Cell
, Issue.8
, pp. 169-169
-
-
Higashitsuji, H.1
Higashitsuji, H.2
Itoh, K.3
Sakurai, T.4
Nagao, T.5
Sumitomo, Y.6
Masuda, T.7
Dawson, S.8
Shimada, Y.9
Mayer, R.J.10
Fujita, J.11
-
15
-
-
33846820426
-
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome
-
Nakamura, Y., Nakano, K., Umehara, T., Kimura, M., Hayashizaki, Y., Tanaka, A., Horikoshi, M., Padmanabhan, B., and Yokoyama, S. (2007) Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome. Structure 15, 179-189.
-
(2007)
Structure
, vol.15
, pp. 179-189
-
-
Nakamura, Y.1
Nakano, K.2
Umehara, T.3
Kimura, M.4
Hayashizaki, Y.5
Tanaka, A.6
Horikoshi, M.7
Padmanabhan, B.8
Yokoyama, S.9
-
16
-
-
0033978257
-
Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
-
Higashitsuji, H., Itoh, K., Nagao, T., Dawson, S., Nonoguchi, K., Kido, T., Mayer, R. J., Arii, S., and Fujita, J. (2000) Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. Nat. Med. 6, 96-99.
-
(2000)
Nat. Med.
, vol.6
, pp. 96-99
-
-
Higashitsuji, H.1
Itoh, K.2
Nagao, T.3
Dawson, S.4
Nonoguchi, K.5
Kido, T.6
Mayer, R.J.7
Arii, S.8
Fujita, J.9
-
17
-
-
0030028728
-
Principles of proteinprotein interactions
-
Jones, S., and Thornton, J. M. (1996) Principles of protein-protein interactions. Proc. Natl. Acad. Sci., U.S.A. 93, 13-20.
-
(1996)
Proc. Natl. Acad. Sci., U.S.A.
, vol.93
, pp. 13-20
-
-
Jones, S.1
Thornton, J.M.2
-
18
-
-
80053367108
-
Probing the druggability of protein-protein interactions: Targeting the Notch1 receptor ankyrin domain using a fragment-based approach
-
Abdel-Rahman, N., Martinez-Arias, A., and Blundell, T. L. (2011) Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach. Biochem. Soc. Trans. 39, 1327-1333.
-
(2011)
Biochem. Soc. Trans.
, vol.39
, pp. 1327-1333
-
-
Abdel-Rahman, N.1
Martinez-Arias, A.2
Blundell, T.L.3
-
19
-
-
79960966093
-
A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo
-
Cronican, J. J., Beier, K. T., Davis, T. N., Tseng, J. C., Li, W., Thompson, D. B., Shih, A. F., May, E. M., Cepko, C. L., Kung, A. L., Zhou, Q., and Liu, D. R. (2011) A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem. Biol. 18, 833-838.
-
(2011)
Chem. Biol.
, vol.18
, pp. 833-838
-
-
Cronican, J.J.1
Beier, K.T.2
Davis, T.N.3
Tseng, J.C.4
Li, W.5
Thompson, D.B.6
Shih, A.F.7
May, E.M.8
Cepko, C.L.9
Kung, A.L.10
Zhou, Q.11
Liu, D.R.12
-
20
-
-
77955881153
-
Potent delivery of functional proteins into mammalian cells in vitro and in vivo using a supercharged protein
-
Cronican, J. J., Thompson, D. B., Beier, K. T., McNaughton, B. R., Cepko, C. L., and Liu, D. R. (2010) Potent delivery of functional proteins into mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem. Biol. 5, 747-752.
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 747-752
-
-
Cronican, J.J.1
Thompson, D.B.2
Beier, K.T.3
McNaughton, B.R.4
Cepko, C.L.5
Liu, D.R.6
-
21
-
-
84889008493
-
Mutagenesis modulates the uptake efficiency, cell-selectivity, and functional enzyme delivery of a protein transduction domain
-
DePorter, S. M., Lui, I., Bruce, V. J., Gray, M. A., Lopez-Islas, M., and McNaughton, B. R. (2014) Mutagenesis modulates the uptake efficiency, cell-selectivity, and functional enzyme delivery of a protein transduction domain. Mol. BioSyst. 10, 18-23.
-
(2014)
Mol. BioSyst.
, vol.10
, pp. 18-23
-
-
DePorter, S.M.1
Lui, I.2
Bruce, V.J.3
Gray, M.A.4
Lopez-Islas, M.5
McNaughton, B.R.6
-
22
-
-
84875425464
-
A protein transduction domain with cell uptake and selectivity profiles that are controlled by multivalency effects
-
DePorter, S. M., Lui, I., Mohan, U., and McNaughton, B. R. (2013) A protein transduction domain with cell uptake and selectivity profiles that are controlled by multivalency effects. Chem. Biol. 20, 434-444.
-
(2013)
Chem. Biol.
, vol.20
, pp. 434-444
-
-
DePorter, S.M.1
Lui, I.2
Mohan, U.3
McNaughton, B.R.4
-
23
-
-
23944483437
-
Cell-penetrating peptides: Tools for intracellular delivery of therapeutics
-
Deshayes, S., Morris, M. C., Divita, G., and Heitz, F. (2005) Cell-penetrating peptides: tools for intracellular delivery of therapeutics. Cell. Mol. Life. Sci. 62, 1839-1849.
-
(2005)
Cell. Mol. Life. Sci.
, vol.62
, pp. 1839-1849
-
-
Deshayes, S.1
Morris, M.C.2
Divita, G.3
Heitz, F.4
-
24
-
-
22444439952
-
Polyarginine as a multifunctional fusion tag
-
Fuchs, S. M., and Raines, R. T. (2005) Polyarginine as a multifunctional fusion tag. Protein Sci. 14, 1538-1544.
-
(2005)
Protein Sci.
, vol.14
, pp. 1538-1544
-
-
Fuchs, S.M.1
Raines, R.T.2
-
25
-
-
34247571930
-
Arginine grafting to endow cell permeability
-
Fuchs, S. M., and Raines, R. T. (2007) Arginine grafting to endow cell permeability. ACS Chem. Biol. 2, 167-170.
-
(2007)
ACS Chem. Biol.
, vol.2
, pp. 167-170
-
-
Fuchs, S.M.1
Raines, R.T.2
-
26
-
-
77955630528
-
A boost for HIV vaccine design
-
Burton, D. R., and Weiss, R. A. (2010) A boost for HIV vaccine design. Science 329, 770-773.
-
(2010)
Science
, vol.329
, pp. 770-773
-
-
Burton, D.R.1
Weiss, R.A.2
-
27
-
-
79954633234
-
A de novo protein binding pair by computational design and directed evolution
-
Karanicolas, J., Corn, J. E., Chen, I., Joachimiak, L. A., Dym, O., Peck, S. H., Albeck, S., Unger, T., Hu, W., Liu, G., Delbecq, S., Montelione, G. T., Spiegel, C. P., Liu, D. R., and Baker, D. (2011) A de novo protein binding pair by computational design and directed evolution. Mol. Cell 42, 250-260.
-
(2011)
Mol. Cell
, vol.42
, pp. 250-260
-
-
Karanicolas, J.1
Corn, J.E.2
Chen, I.3
Joachimiak, L.A.4
Dym, O.5
Peck, S.H.6
Albeck, S.7
Unger, T.8
Hu, W.9
Liu, G.10
Delbecq, S.11
Montelione, G.T.12
Spiegel, C.P.13
Liu, D.R.14
Baker, D.15
-
28
-
-
84863704394
-
Split-superpositive GFP reassembly is a fast, efficient, and robust method for detecting protein-protein interactions in vivo
-
Blakeley, B. D., Chapman, A. M., and McNaughton, B. R. (2012) Split-superpositive GFP reassembly is a fast, efficient, and robust method for detecting protein-protein interactions in vivo. Mol. BioSyst. 8, 2036-2040.
-
(2012)
Mol. BioSyst.
, vol.8
, pp. 2036-2040
-
-
Blakeley, B.D.1
Chapman, A.M.2
McNaughton, B.R.3
-
29
-
-
33644625564
-
Reassembled GFP: Detecting protein-protein interactions and protein expression patterns
-
Magliery, T. J., and Regan, L. (2006) Reassembled GFP: detecting protein-protein interactions and protein expression patterns. Methods Biochem. Anal. 47, 391-405.
-
(2006)
Methods Biochem. Anal.
, vol.47
, pp. 391-405
-
-
Magliery, T.J.1
Regan, L.2
-
30
-
-
11844252081
-
Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: Scope and mechanism
-
Magliery, T. J., Wilson, C. G., Pan, W., Mishler, D., Ghosh, I., Hamilton, A. D., and Regan, L. (2005) Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. J. Am. Chem. Soc. 127, 146-157.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 146-157
-
-
Magliery, T.J.1
Wilson, C.G.2
Pan, W.3
Mishler, D.4
Ghosh, I.5
Hamilton, A.D.6
Regan, L.7
-
31
-
-
24144454858
-
Detecting protein-protein interactions with GFP-fragment reassembly
-
Wilson, C. G., Magliery, T. J., and Regan, L. (2004) Detecting protein-protein interactions with GFP-fragment reassembly. Nat. Methods 1, 255-262.
-
(2004)
Nat. Methods
, vol.1
, pp. 255-262
-
-
Wilson, C.G.1
Magliery, T.J.2
Regan, L.3
-
32
-
-
34548174652
-
Supercharging proteins can impart unusual resilience
-
Lawrence, M. S., Phillips, K. J., and Liu, D. R. (2007) Supercharging proteins can impart unusual resilience. J. Am. Chem. Soc. 129, 10110-10112.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 10110-10112
-
-
Lawrence, M.S.1
Phillips, K.J.2
Liu, D.R.3
-
33
-
-
0035793406
-
Protein design of an HIV-1 entry inhibitor
-
For a similar pull-down experiment, see Root, M. J., Kay, M. S., and Kim, P. S. (2001) Protein design of an HIV-1 entry inhibitor. Science 291, 884-888.
-
(2001)
Science
, vol.291
, pp. 884-888
-
-
Root, M.J.1
Kay, M.S.2
Kim, P.S.3
|