CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine

Archives of Toxicology

Volumn 90, Issue 7, 2016, Pages 1737-1748

  Tian, Ye ^b,d   Shen, Shuijie ^c   Jiang, Yan ^b   Shen, Qi ^b   Zeng, Su ^b   Zheng, Jiang ^a,c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c UNIVERSITY OF WASHINGTON   (United States)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bioactivation; CYP3A5; Quinone methide; Tetrandrine

Indexed keywords

CASPASE 3; CYTOCHROME P450 3A5; GLUTATHIONE; LACTATE DEHYDROGENASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TETRANDRINE; BENZYLISOQUINOLINE DERIVATIVE; CYP3A5 PROTEIN, HUMAN; CYTOCHROME P450 3A;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; METABOLIC ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; WILD TYPE; CELL CULTURE TECHNIQUE; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; LUNG; METABOLISM; PATHOLOGY; PLASMID; TRANSGENE;

ACTIVATION, METABOLIC; APOPTOSIS; BENZYLISOQUINOLINES; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; CYTOCHROME P-450 CYP3A; FLOW CYTOMETRY; GLUTATHIONE; HUMANS; L-LACTATE DEHYDROGENASE; LUNG; PLASMIDS; REACTIVE OXYGEN SPECIES; TRANSGENES;

EID: 84939832993     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1584-8     Document Type: Article

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