Investigation of bioactivation and toxicity of styrene in CYP2E1 transgenic cells

Toxicology

Volumn 226, Issue 2-3, 2006, Pages 99-106

  Chung, Jou Ku ^a   Yuan, Wei ^a   Liu, Guangxian ^a   Zheng, Jiang ^a,b  

^a NORTHEASTERN UNIVERSITY   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

CYP2E1; Styrene; Styrene 7,8 oxide

Indexed keywords

ACETYLCYSTEINE; CYCLOHEXANE DERIVATIVE; CYTOCHROME P450 2E1; EPOXIDE; EPOXIDE HYDROLASE; ETHYLBENZENE; ETHYLCYCLOHEXANE; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; MICROSOME ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STYRENE; UNCLASSIFIED DRUG; VINYL DERIVATIVE; VINYLCYCLOHEXANE;

ANALYTIC METHOD; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; EPOXIDATION; HUMAN; HUMAN CELL; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; TRANSGENICS; WILD TYPE;

ACETYLCYSTEINE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOTRANSFORMATION; CELL SURVIVAL; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; ENZYME INHIBITORS; EPOXIDE HYDROLASES; EPOXY COMPOUNDS; GLUTATHIONE; HUMANS; STYRENE; STYRENES;

EID: 33747813540     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.06.001     Document Type: Article

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