Evidence that subanesthetic doses of ketamine cause sustained disruptions of NMDA and AMPA-mediated frontoparietal connectivity in humans

Journal of Neuroscience

Volumn 35, Issue 33, 2015, Pages 11694-11706

  Muthukumaraswamy, Suresh D ^a   Shaw, Alexander D ^b   Jackson, Laura E ^c   Hall, Judith ^c   Moran, Rosalyn ^d   Saxena, Neeraj ^b,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c University of South Wales   (United Kingdom)

^d VIRGINIA TECH CARILION SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha rhythms; Depression; Dynamic causal modelling; Gamma rhythms; Ketamine; Magnetoencephalography

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; AMPA RECEPTOR; ANESTHETIC AGENT; ANTIDEPRESSANT AGENT;

ADULT; ANESTHESIA; ANTERIOR CINGULATE; ARTICLE; BLOOD OXYGENATION; BRAIN CORTEX; CONNECTOME; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; ELECTROOCULOGRAPHY; FRONTOPARIETAL CORTEX; HUMAN; HUMAN EXPERIMENT; MAGNETOENCEPHALOGRAPHY; MALE; MATHEMATICAL MODEL; OCCIPITAL CORTEX; PARIETAL CORTEX; PRIORITY JOURNAL; PULSE RATE; PUPILLOMETRY; PYRAMIDAL NERVE CELL; SPECTRAL SENSITIVITY; ANTAGONISTS AND INHIBITORS; BRAIN MAPPING; DOSE RESPONSE; DRUG EFFECTS; ELECTROENCEPHALOGRAM; FRONTAL LOBE; METABOLISM; NERVE TRACT; PARIETAL LOBE; PHYSIOLOGY; YOUNG ADULT;

ADULT; ANESTHETICS, DISSOCIATIVE; ANTIDEPRESSIVE AGENTS; BRAIN MAPPING; BRAIN WAVES; DOSE-RESPONSE RELATIONSHIP, DRUG; FRONTAL LOBE; HUMANS; KETAMINE; MALE; NEURAL PATHWAYS; PARIETAL LOBE; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; YOUNG ADULT;

EID: 84939824087     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0903-15.2015     Document Type: Article

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