Mechanism of action of ketamine

CNS Spectrums

Volumn 18, Issue 4, 2013, Pages 171-174

  Stahl, Stephen M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; AMPA RECEPTOR; DEXTROMETHORPHAN; FLUVOXAMINE; KETAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SIGMA 1 OPIATE RECEPTOR;

ANTIDEPRESSANT ACTIVITY; ARTICLE; BIPOLAR DEPRESSION; CHRONIC PAIN; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; MAJOR DEPRESSION; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SUICIDE;

DEPRESSIVE DISORDER, TREATMENT-RESISTANT; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; KETAMINE; RECEPTORS, N-METHYL-D-ASPARTATE; SUICIDAL IDEATION; TREATMENT OUTCOME;

EID: 84880541970     PISSN: 10928529     EISSN: None     Source Type: Journal    
DOI: 10.1017/S109285291300045X     Document Type: Article

References (7)

1. Stahl SM. Stahl's Essential Psychopharmacology, 4th ed. New York: Cambridge University Press; 2013.
2. Cateno-Dell'Ossa M, Gagiolini A, Rotella F, Baroni S, Marazziti D. Glutamate system as target for development of novel antidepressants. CNS Spectr. in press.
3. Bunney BG, Bunney WE. Rapid-acting antidepressant strategies: mechanisms of action. Int J Neuropsychopharmacol. 2012; 15: 695-713.
4. Ibrahim L, Diazgranados N, Franco-Chaves J, et al. Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebocontrolled study. Neuropsychopharmacology. 2012; 37(6): 1526-1533.
5. Li N, Lee B, Liu R-J, et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010; 329: 959-964.
6. Stahl SM. The sigma enigma: can sigma receptors provide a novel target for disorders of mood and cognition? J Clin Psychiatry. 2008; 69: 1673-1674.
7. Stahl SM. Mechanism of action of dextromethorphan/ quinidine. CNS Spectr. in press.