A polybasic plasma membrane binding motif in the I-II linker stabilizes voltage-gated CaV1.2 calcium channel function

Journal of Biological Chemistry

Volumn 290, Issue 34, 2015, Pages 21086-21100

  Kaur, Gurjot ^a   Pinggera, Alexandra ^a   Ortner, Nadine J ^a   Lieb, Andreas ^a   Sinnegger Brauns, Martina J ^a   Yarov Yarovoy, Vladimir ^b   Obermair, Gerald J ^c   Flucher, Bernhard E ^c   Striessnig, Jörg ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ARGININE; CALCIUM; CELL MEMBRANES; CHEMICAL ACTIVATION; ELECTROPHYSIOLOGY; GENE EXPRESSION; PHOSPHOLIPIDS; PHYSIOLOGY;

IMMUNOFLUORESCENCE MICROSCOPY; MOLECULAR MECHANISM; MUSCLE CONTRACTIONS; NEGATIVELY CHARGED; PATCH CLAMP RECORDING; PHOSPHOLIPASE C ACTIVATIONS; PHYSIOLOGICAL FUNCTIONS; PRIMARY STRUCTURES;

MEMBRANES;

ARGININE; CALCIUM CHANNEL L TYPE; CALCIUM ION; L TYPE VOLTAGE GATED CALCIUM CHANNEL CAV1.2 ALPHA1 SUBUNIT; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; UNCLASSIFIED DRUG; CACNA1A PROTEIN, HUMAN; CACNA1S PROTEIN, HUMAN; CALCIUM; CALCIUM CHANNEL; HYBRID PROTEIN; L-TYPE CALCIUM CHANNEL ALPHA(1C);

ALPHA HELIX; ARTICLE; CALCIUM CELL LEVEL; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; I-II LINKER; IMMUNOFLUORESCENCE MICROSCOPY; LIVE CELL IMAGING; MEMBRANE BINDING; MOLECULAR MODEL; POLYBASIC PLASMA MEMBRANE BINDING MOTIF; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TRANSPORT; WHOLE CELL PATCH CLAMP; AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; HUMAN; ION TRANSPORT; METABOLISM; MOLECULAR GENETICS; MUTATION; PATCH CLAMP TECHNIQUE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; TRANSFORMED CELL LINE;

AMINO ACID SEQUENCE; CALCIUM; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CELL LINE, TRANSFORMED; CELL MEMBRANE; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; ION TRANSPORT; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TYPE C PHOSPHOLIPASES;

EID: 84939823948     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.645671     Document Type: Article

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