Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for β1 but not for palmitoylated β2, implicating an additional binding site in the regulation of channel voltage-dependent properties

Journal of Neuroscience

Volumn 25, Issue 30, 2005, Pages 6984-6996

  Leroy, Jérôme ^a   Richards, Mark S ^a,b   Butcher, Adrian J ^a   Nieto Rostro, Manuela ^a   Pratt, Wendy S ^a   Davies, Anthony ^a   Dolphin, Annette C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Interaction domain; Subunit; Calcium channel; G protein; Neuron; Palmitoylation; Trafficking

Indexed keywords

ALANINE; CALCIUM CHANNEL N TYPE; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; QUINPIROLE; TRYPTOPHAN; VOLTAGE GATED CALCIUM CHANNEL;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; CALCIUM CURRENT; CELL MEMBRANE; CONTROLLED STUDY; FACILITATION; HYPERPOLARIZATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR UPREGULATION; STEADY STATE;

ANIMALS; BINDING SITES; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; CELL MEMBRANE; CELLS, CULTURED; GTP-BINDING PROTEINS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; NEURONS; PALMITIC ACID; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RABBITS; RATS; TRANSFECTION; TRYPTOPHAN;

EID: 23044516268     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1137-05.2005     Document Type: Article

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