Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages 16598-16603

  Fu, Ying ^a   Westenbroek, Ruth E ^a   Scheuer, Todd ^a   Catterall, William A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCIUM CHANNEL CAV1.2; CALCIUM CHANNEL L TYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; SERINE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; 1,4-DIHYDROPYRIDINE; BARIUM; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CACNA1C PROTEIN, MOUSE; CALCIUM; CASEIN KINASE II; DIHYDROPYRIDINE DERIVATIVE; PHOSPHOSERINE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM CURRENT; CALCIUM HOMEOSTASIS; CHANNEL GATING; CONTROLLED STUDY; EXCITATION CONTRACTION COUPLING; EXERCISE TOLERANCE; HEART CONTRACTION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MOUSE MUTANT; MUSCLE FIBER CONTRACTION; NEWBORN; NONHUMAN; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; WILD TYPE; ADAPTATION; AMINO ACID SUBSTITUTION; ANIMAL; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HEART ARRHYTHMIA; HEART FAILURE; HYPERTROPHIC CARDIOMYOPATHY; ION TRANSPORT; METABOLISM; MISSENSE MUTATION; MUTANT MOUSE STRAIN; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

MUS;

ADAPTATION, PHYSIOLOGICAL; ADRENERGIC BETA-AGONISTS; AMINO ACID SUBSTITUTION; ANIMALS; ARRHYTHMIAS, CARDIAC; BARIUM; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARDIOMYOPATHY, HYPERTROPHIC; CASEIN KINASE II; DIHYDROPYRIDINES; EXERCISE TOLERANCE; HEART FAILURE; ION TRANSPORT; ISOPROTERENOL; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MODELS, MOLECULAR; MUTATION, MISSENSE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PHOSPHOSERINE; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84915820073     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419129111     Document Type: Article

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