Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Yu, Rilei ^a,c   Seymour, Victoria A L ^b   Berecki, Géza ^b   Jia, Xinying ^a   Akcan, Muharrem ^a,d   Adams, David J ^b   Kaas, Quentin ^a   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b RMIT UNIVERSITY   (Australia)

^c OCEAN UNIVERSITY OF CHINA   (China)

^d DUMLUPINAR UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ALPHA-CONOTOXIN VC1.1; AMIDE; ANALGESIC AGENT; CALCIUM CHANNEL; CONOTOXIN; DISULFIDE; NICOTINIC RECEPTOR; RECOMBINANT PROTEIN; SOLUTION AND SOLUBILITY;

AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; ENZYME STABILITY; GENETICS; IC50; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OOCYTE; PROTEIN CONFORMATION; RAT; SOLUTION AND SOLUBILITY; TEMPERATURE; XENOPUS;

AMIDES; AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; CALCIUM CHANNELS; CELL LINE; CONOTOXINS; DISULFIDES; ENZYME STABILITY; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PROTEIN CONFORMATION; RATS; RECEPTORS, GABA; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS; SOLUTIONS; TEMPERATURE; XENOPUS;

EID: 84939817929     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13264     Document Type: Article

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