Infertility and miscarriage: Common pathways in manifestation and management

Women's Health

Volumn 11, Issue 4, 2015, Pages 527-541

  Agenor, Angena ^a   Bhattacharya, Sohinee ^b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ABERDEEN MATERNITY HOSPITAL   (United Kingdom)

Author keywords

advanced maternal age; assisted reproductive technology; infertility; miscarriage; recurrent miscarriage; spontaneous abortion; subfertility

Indexed keywords

ACETYLSALICYLIC ACID; BLOOD CLOTTING FACTOR 5 LEIDEN; CHORIONIC GONADOTROPIN; HEPARIN; IMMUNOGLOBULIN; LOW MOLECULAR WEIGHT HEPARIN; METFORMIN; PLACEBO; PREDNISOLONE; PROGESTERONE; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; CYTOKINE; HLA ANTIGEN; INTEGRIN; LEUKEMIA INHIBITORY FACTOR; MUCIN 1; PHOSPHOLIPID ANTIBODY;

ACTIVE IMMUNIZATION; ALCOHOL CONSUMPTION; ANTIGEN EXPRESSION; CELL INTERACTION; CHROMOSOME ABERRATION; CLINICAL FEATURE; CLINICAL TRIAL (TOPIC); COMORBIDITY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOMETRIOSIS; FEMALE INFERTILITY; FEMALE SUBFERTILITY; GENE MUTATION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; HEMOSTASIS; HIGH RISK POPULATION; HUMAN; IMMUNOPATHOGENESIS; INFERTILITY; INFERTILITY THERAPY; LIFESTYLE MODIFICATION; MATERNAL AGE; MATERNAL OBESITY; MORBIDITY; OUTCOME ASSESSMENT; OVARY POLYCYSTIC DISEASE; PASSIVE IMMUNIZATION; PREGNANCY RATE; PRENATAL DIAGNOSIS; PREVALENCE; PROTEIN EXPRESSION; RECURRENT ABORTION; REVIEW; RISK FACTOR; SMOKING; SOCIAL STIGMA; SPONTANEOUS ABORTION; UTERUS MALFORMATION; VAGINA BLEEDING; ABORTION, SPONTANEOUS; ADULT; AGE; BIOSYNTHESIS; DRINKING BEHAVIOR; FEMALE; GENETICS; IMMUNOLOGY; INFERTILITY, FEMALE; METABOLISM; NATURAL KILLER CELL; OBESITY; PREGNANCY;

ABORTION, SPONTANEOUS; ADULT; AGE FACTORS; ALCOHOL DRINKING; ANTIBODIES, ANTIPHOSPHOLIPID; CHROMOSOME ABERRATIONS; COMORBIDITY; CYTOKINES; FEMALE; HLA ANTIGENS; HUMANS; INFERTILITY, FEMALE; INTEGRINS; KILLER CELLS, NATURAL; LEUKEMIA INHIBITORY FACTOR; MUCIN-1; OBESITY; PREGNANCY; PREVALENCE; REPRODUCTIVE TECHNIQUES, ASSISTED; RISK FACTORS; SMOKING;

EID: 84939805900     PISSN: 17455057     EISSN: 17455065     Source Type: Journal    
DOI: 10.2217/whe.15.19     Document Type: Review

References (147)

1. Choudhury SR, Knapp LA. Human reproductive failure I: immunological factors. Hum. Reprod. Update 7(2), 113-134 (2001
2. Sagili H, Divers M. Modern management of miscarriage. The Obstetrician & Gynaecologist 9(2), 102-108 (2007
3. Bottomley C, Bourne T. Diagnosing miscarriage. Best Pract. Res. Clin. Obstet. Gynaecol. 23(4), 463-477 (2009
4. Cauchi MN, Coulam CB, Cowchock S et al. Predictive factors in recurrent spontaneous aborters-A multicenter study. Am. J. Reprod. Immunol. 33(2), 165-170 (1995
5. Hakim RB, Gray RH, Zacur H. Infertility and early pregnancy loss. Obstet. Gynecol. 172(5), 1510-1517 (1995
6. Christiansen OB, Nielsen HS, Kolte AM. Future directions of failed implantation and recurrent miscarriage research. Reprod. Biomed. Online 13(1), 71-83 (2006
7. Cunningham GF, Macdonald CP, Grant FN et al. Reproduction success and failure. In: Williams Obstetrics. Appleton & Lange, 579-581 (1997
8. Zegers-Hochschild F, Adamson GD, de Mouzon J et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil. Steril. 92(5), 1520-1524 (2009
9. Guttmacher AF. Factors affecting normal expectancy of conception. J. Am. Med. Assoc. 161(9), 855-860 (1956
10. Cramer DW, Walker AM, Schiff I. Statistical methods in evaluating the outcome of infertility therapy. Fertil. Steril. 32(1), 80-86 (1979
11. WHO/MCH. Infertility: a Tabulation of Available Data on Primary and Secondary Infertility. WHO, Geneva, Switzerland (1991
12. Gurunath S, Pandian Z, Anderson RA, Bhattacharya S. Defining infertility-A systematic review of prevalence studies. Hum. Reprod. Update 17(5), 575-588 (2011
13. WHO. Infertility definitions and terminology. www.who.int
14. Reiss HE. Reproductive Medicine From A to Z. Oxford University Press, Oxford, UK (1998
15. Farquharson RG, Jauniaux E, Exalto N. ESHRE Special Interest Group for Early Pregnancy (SIGEP). Updated and revised nomenclature for description of early pregnancy events. Hum. Reprod. 20(11), 3008-3011 (2005
16. Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum. Reprod. 22(6), 1506-1512 (2007
17. Savitz DA, Hertz-Picciotto I, Poole C, Olshan AF. Epidemiologic measures of the course and outcome of pregnancy. Epidemiol. Rev. 24(2), 91-101 (2002
18. Zinaman MJ, Clegg ED, Brown CC, O'Connor J, Selevan SG. Estimates of human fertility and pregnancy loss. Fertil. Steril. 65(3), 503-509 (1996
19. Regan L, Braude PR, Trembath PL. Influence of past reproductive performance on risk of spontaneous abortion. BMJ 299(6698), 541-545 (1989
20. Bansal AS, Bajardeen B, Shehata H, Thum M. Recurrent miscarriage and autoimmunity. Expert Rev. Clin. Immunol. 7(1), 37-44 (2011
21. Hutter H, Dohr G. HLA expression on immature and mature human germ cells. J. Reprod. Immunol. 38(2), 101-122 (1998
22. Fernandez N, Cooper J, Sprinks M et al A critical review of the role of the major histocompatibility complex in fertilization, preimplantation development and feto-maternal interactions. Hum. Reprod. Update 5(3), 234-248 (1999
23. Ober C, van der Ven K. Immunogenetics of reproduction: an overview. Curr. Top. Microbiol. Immunol. 222, 1-23 (1997
24. Ober C, Hyslop T, Elias S, Weitkamp LR, Hauck WW. Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study. Hum. Reprod.13(1), 33-38 (1998
25. Taylor C, Faulk WP. Prevention of recurrent abortion with leucocyte transfusions. Lancet 2(8237), 68-70 (1981
26. McIntyre JA, McConnachie PR, Taylor CG, Faulk WP. Clinical, immunologic, and genetic definitions of primary and secondary recurrent spontaneous abortions. Fertil. Steril. 42(6), 849-855 (1984
27. Mowbray JF, Gibbings C, Liddell H, Reginald PW, Underwood JL, Beard RW. Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells. Lancet 1(8435), 941-943 (1985
28. Regan L, Braude PR, Hill DP A prospective study of the incidence, time of appearance and significance of antipaternal lymphocytotoxic antibodies in human pregnancy. Hum. Reprod.6(2), 294-298 (1991
29. Regan L, Braude PR. Is antipaternal cytotoxic antibody a valid marker in the management of recurrent abortion?. Lancet 2, 1280 (1987
30. Mazumdar S, Levine AS. Antisperm antibodies: etiology, pathogenesis, diagnosis, and treatment. Fertil. Steril. 70(5), 799-810 (1998
31. Dimitrov DG, Urbanek V, Zvina J, Madar J, Nouza K, Kinsky R. Correlation of asthenozoospermia with increased antisperm cell-mediated immunity in men from infertile couples. J. Reprod. Immunol. 27(1), 3-12 (1994
32. Telang M, Reyniak JV, Shulman S. Antibodies to spermatozoa. VIII. Correlation of sperm antibody activity with postcoital tests in infertile couples. Int. J. Fertil. 23(3), 200-206 (1978
33. Moghissi KS, Sacco AG, Borin K. Immunologic infertility. I. Cervical mucus antibodies and postcoital test. Am. J. Obstet. Gynecol. 136(7), 941-950 (1980
34. Witkin SS, David SS. Effect of sperm antibodies on pregnancy outcome in a subfertile population. Obstet. Gynecol. 158(1), 59-62 (1988
35. Haas GG Jr, Kubota K, Quebbeman JF, Jijon A, Menge AC, Beer AE. Circulating antisperm antibodies in recurrently aborting women. Fertil. Steril. 45(2), 209-215 (1986
36. Check JH, Katsoff D, Bollendorf A, Callan C. The effect of sera antisperm antibodies in the female partner on in vivo and in vitro pregnancy and spontaneous abortion rates. Am. J. Reprod. Immunol. 33(1), 131-133 (1995
37. Rajah SV, Parslow JM, Howell RJ, Hendry WF. The effects on in-vitro fertilization of autoantibodies to spermatozoa in subfertile men. Hum. Reprod. 8(7), 1079-1082 (1993
38. Nip MM, Taylor PV, Rutherford AJ, Hancock KW. Autoantibodies and antisperm antibodies in sera and follicular fluids of infertile patients; relation to reproductive outcome after in-vitro fertilization. Hum. Reprod. 10(10), 2564-2569 (1995
39. Cho C, Bunch DO, Faure JE et al. Fertilization defects in sperm from mice lacking fertilin beta. Science 281(5384), 1857-1859 (1998
40. Lessey BA, Damjanovich L, Coutifaris C, Castelbaum A, Albelda SM, Buck CA. Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J. Clin. Invest. 90(1), 188-195 (1992
41. Arici A, Oral E, Bahtiyar O, Engin O, Seli E, Jones EE. Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells. Hum. Reprod. 12(6), 1233-1239 (1997
42. Senturk LM, Arici A. Leukemia inhibitory factor in human reproduction. Am. J. Reprod. Immunol. 39(2), 144-151 (1998
43. Ozornek MH, Bielfeld P, Krussel JS, Hirchenhain J, Jeyendran RS, Koldovsky U. Epidermal growth factor and leukemia inhibitory factor levels in follicular fluid. Association with in vitro fertilization outcome. J. Reprod. Med. 44(4), 367-369 (1999
44. Hambartsoumian E. Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation. Am. J. Reprod. Immunol. 39(2), 137-143 (1998
45. Bahar AM, Kwak JY, Beer AE et al. Antibodies to phospholipids and nuclear antigens in non-pregnant women with unexplained spontaneous recurrent abortions. J. Reprod. Immunol. 24(3), 213-222 (1993
46. Kwak JYH, Gilman-Sachs A, Beaman KD, Beer AE. Autoantibodies in women with primary recurrent spontaneous abortion of unknown etiology. J. Reprod. Immunol. 22(1), 15-31 (1992
47. Matzner W, Chong P, Xu G, Ching W. Characterization of antiphospholipid antibodies in women with recurrent spontaneous abortions. J. Reprod. Med. 39(1), 27-30 (1994
48. Coulam CB. The role of antiphospholipid antibodies in reproduction: questions answered and raised at the 18th Annual Meeting of the American Society of Reproductive Immunology. Am. J. Reprod. Immunol. 41(1), 1-4 (1999
49. Birkenfeld A, Mukaida T, Minichiello L, Jackson M, Kase NG, Yemini M. Incidence of autoimmune antibodies in failed embryo transfer cycles. Am. J. Reprod. Immunol. 31(2-3), 65-68 (1994
50. Geva E, Yaron Y, Lessing JB et al. Circulating autoimmune antibodies may be responsible for implantation failure in in vitro fertilization. Fertil. Steril. 62(4), 802-806 (1994
51. Dmowski WP, Rana N, Michalowska J, Friberg J, Papierniak C, el-Roeiy A. The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates. Fertil. Steril. 63(3), 555-562 (1995
52. Sher G, Feinman M, Zouves C et al. High fecundity rates following in-vitro fertilization and embryo transfer in antiphospholipid antibody seropositive women treated with heparin and aspirin. Hum. Reprod. 9(12), 2278-2283 (1994
53. Gleicher N. Introduction-The worldwide collaborative observational study and MULTI-Analysis on allogeneic leukocyte immunotherapy for recurrent abortion. Am. J. Reprod. Immunol. 32(2), 53-54 (1994
54. Denis A, Guido M, Adler RD, Bergh PA, Brenner C, Scott Jr RT. Antiphospholipid antibodies and pregnancy rates and outcome in in vitro fertilization patients. Fertil. Steril. 67(6), 1084-1090 (1997
55. D'Ippolito S, Meroni PL, Koike T, Veglia M, Scambia G, Di Simone N. Obstetric antiphospholipid syndrome: a recent classification for an old defined disorder. Autoimmun. Rev. 13(9), 901-908 (2014
56. Clark DA. T cells in pregnancy: illusion and reality. Am. J. Reprod. Immunol. 41(4), 233-238 (1999
57. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17(3), 138-146 (1996
58. Elson LH, Calvopina M, Paredes W et al. Immunity to onchocerciasis: putative immune persons produce a Th1-like response to Onchocerca volvulus. J. Infect. Dis. 171(3), 652-658 (1995
59. Mustafa M, Vingsbo C, Olsson T, Ljungdahl A, Hojeberg B, Holmdahl R. The major histocompatibility complex influences myelin basic protein 63-88-induced T cell cytokine profile and experimental autoimmune encephalomyelitis. Eur. J. Immunol. 23(12), 3089-3095 (1993
60. Hill JA, Polgar K, Anderson DJ. T-helper 1-Type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 273(24), 1933-1936 (1995
61. Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R. Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum. Reprod. 15(3), 713-718 (2000
62. Szereday L, Varga P, Szekeres-Bartho J. Cytokine production by lymphocytes in pregnancy. Am. J. Reprod. Immunol. 38(6), 418-422 (1997
63. Kwak JYH, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz D, Beer AE. Up-regulated expression of CD56+, CD56+/CD16+, and CD19+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am. J. Reprod. Immunol. 34(2), 93-99 (1995
64. Aoki K, Kajiura S, Matsumoto Y et al. Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 345(8961), 1340-1342 (1995
65. Vassiliadou N, Bulmer JN. Immunohistochemical evidence for increased numbers of 'classic' CD57+ natural killer cells in the endometrium of women suffering spontaneous early pregnancy loss. Hum. Reprod. 11(7), 1569-1574 (1996
66. Bulmer JN, Hollings D, Ritson A. Immunocytochemical evidence that endometrial stromal granulocytes are granulated lymphocytes. J. Pathol. 153(3), 281-288 (1987
67. Quenby S, Bates M, Doig T et al. Pre-implantation endometrial leukocytes in women with recurrent miscarriage. Hum. Reprod. 14(9), 2386-2391 (1999
68. Kwak JY, Beer AE, Kim SH, Mantouvalos HP. Immunopathology of the implantation site utilizing monoclonal antibodies to natural killer cells in women with recurrent pregnancy losses. Am. J. Reprod. Immunol. 41(1), 91-98 (1999
69. King A, Balendran N, Wooding P, Carter NP, Loke YW. CD3-leukocytes present in the human uterus during early placentation: phenotypic and morphologic characterization of the CD56++ population. Dev. Immunol. 1(3), 169-190 (1991
70. Kupferminc MJ, Eldor A, Steinman N et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N. Engl. J. Med. 340(1), 9-13 (1999
71. Bellver J, Soares SR, Alvarez C et al. The role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion. Hum. Reprod. 23, 278-284 (2008
72. Vaquero E, de Felice G, Valensise H, Lazzarin N. Cell immunity and recurrent miscarriage. Miscarriages: Causes, Symptoms and Prevention, 29-53 (2012
73. Nguyen PV, Kafka JK, Ferreira VH, Roth K, Kaushic C. Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection. Cell. Mol. Immunol. 11(5), 410-427 (2014
74. Fatemi HM, Popovic-Todorovic B. Implantation in assisted reproduction: a look at endometrial receptivity. Reprod. Biomed. Online 27(5), 530-538 (2013
75. Carvalho B, Doria S, Ramalho C et al. Aneuploidies detection in miscarriages and fetal deaths using multiplex ligation-dependent probe amplification: an alternative for speeding up results?. Eur. J. Obst. Gynecol. Reprod. Biol. 153(2), 151-155 (2010
76. Teklenburg G, Salker M, Heijnen C, Macklon NS, Brosens JJ. The molecular basis of recurrent pregnancy loss: impaired natural embryo selection. Mol. Hum. Reprod. 16(12), 886-895 (2010
77. Goddijn M, Leschot NJ. Genetic aspects of miscarriage. Baillieres Best Pract. Res. Clin. Obstet. Gynaecol. 14(5), 855-865 (2000
78. Rajcan-Separovic E, Diego-Alvarez D, Robinson WP et al. Identification of copy number variants in miscarriages from couples with idiopathic recurrent pregnancy loss. Hum. Reprod. 25(11), 2913-2922 (2010
79. Rosenmann A, Wahrman J, Richler C, Voss R, Persitz A, Goldman B. Meiotic association between the XY chromosomes and unpaired autosomal elements as a cause of human male sterility. Cytogenet. Cell Genet. 39(1), 19-29 (1985
80. Luciani JM, Guichaoua MR, Mattei A, Morazzani MR. Pachytene analysis of a man with a 13q; 14q translocation and infertility. Behavior of the trivalent and nonrandom association with the sex vesicle. Cytogenet. Cell Genet. 38(1), 14-22 (1984
81. Dizon-Townson DS, Kinney S, Branch DW et al. The Factor V Leiden mutation is not a common cause of recurrent miscarriage. J. Reprod. Immunol. 34, 217-223 (1997
82. Grandone E, Margaglione M, Colaizzo D et al. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb. Haemost. 77(5), 822-824 (1997
83. Ridker PM, Miletich JP, Buring JE et al. Factor V Leiden mutation as a risk factor for recurrent pregnancy loss. Ann. Intern. Med. 128, 1000-1003 (1998
84. Dizon-Townson DS, Meline L, Nelson LM, Varner M, Ward K. Fetal carriers of the Factor V Leiden mutation are prone to miscarriage and placental infarction. Am. J. Obstet. Gynecol. 177(2), 402-405 (1997
85. Hashimoto K, Shizusawa Y, Shimoya K et al. The Factor V Leiden mutation in Japanese couples with recurrent spontaneous abortion. Hum. Reprod. 14(7), 1872-1874 (1999
86. Coumans AB, Huijgens PC, Jakobs C et al. Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion. Hum. Reprod. 14(1), 211-214 (1999
87. McFadden DE, Kalousek D. Survey of neural tube defects in spontaneous aborted embryos. Am. J. Med. Genet. 32, 356-358 (1989
88. Rosenbusch B, Sterzik K. Sperm chromosomes and habitual abortion. Fertil. Steril. 56, 370-372 (1991
89. Stein ZA A woman's age: child bearing and child rearing. J. Epidemiol. 21, 327-42 (1985
90. Hassold T, Chiu D. Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy. Hum. Genet. 70(1), 11-17 (1985
91. Eichenlaub-Ritter U. Parental age-related aneuploidy in human germ cells and offspring: a story of past and present. Environ. Mol. Mutagen. 28(3), 211-236 (1996
92. Faddy MJ. Follicle dynamics during ovarian ageing. Mol. Cell. Endocrinol. 163(1-2), 43-48 (2000
93. van Kooij RJ, Looman CW, Habbema JD, Dorland M, te Velde ER. Age-dependent decrease in embryo implantation rate after in vitro fertilization. Fertil. Steril. 66(5), 769-775 (1996
94. Bellver J. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil. Steril. 79, 1136-1140 (2003
95. Metwally M, Saravelos SH, Ledger WL, Li TC. Body mass index and risk of miscarriage in women with recurrent miscarriage. Fertil. Steril. 94, 290-295 (2010
96. Metwally M, Ong KJ, Ledger WL, Li TC. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-Analysis of the evidence. Fertil. Steril. 90, 714-726 (2008
97. Stillman RJ. Seminars in reproductive endocrinology: smoking and reproductive health. New York: Thieme Medical Publishers (1989
98. Stillman RJ, Rosenberg MJ, Sachs BP. Smoking and reproduction. Fertil. Steril. 46, 545-566 (1986
99. Weisberg E. Smoking and reproductive health. Clin. Reprod. Fertil. 3, 175-186 (1985
100. Fredricsson B, Gilljam H. Smoking and reproduction: short and long term effects and benefits of smoking cessation. Acta Obstet. Gynecol. Scand. 71, 580-892 (1992
101. Hughes EG, Brennan BG. Does cigarette smoking impair natural or assisted fecundity?. Fertil. Steril. 66, 679-689 (1996
102. Augood C, Duckitt K, Templeton AA. Smoking and female infertility: a systematic review and meta-Analysis. Hum. Reprod. 13, 1532-1539 (1998
103. Hull MG, North K, Taylor H, Farrow A, Ford WC. Delayed conception and active and passive smoking: the Avon Longitudinal Study of pregnancy and childhood study team. Fertil. Steril. 74, 725-733 (2000
104. Winter E, Wang J, Davies MJ, Norman R. Early pregnancy loss following assisted reproductive technology treatment. Hum. Reprod. 17, 3220-3223 (2002
105. Ness RB, Grisso JA, Hirschinger N et al. Cocaine and tobacco use and the risk of spontaneous abortion. N. Engl. J. Med. 340, 333-339 (1999
106. Practice Committee of the American Society for Reproductive Medicine. Smoking and infertility: a committee opinion. Fertil. Steril. 98(6), 1400-1406 (2012
107. Garc?'a-Engu?'danos A, Calle ME, Valero J, Luna S, Dom?'nguez-Rojas V. Risk factors in miscarriage: a review. Eur. J. Obstet. Gynecol. Reprod. Biol. 102(2), 111-119 (2002
108. Abel EL. Maternal alcohol consumption and spontaneous abortion. Alcohol Alcohol. 32, 211-219 (1997
109. Harlap S, Shiono PH. Alcohol, smoking, and incidence of spontaneous abortion in the first and second trimester. Lancet 2, 173-176 (1980
110. Anokute CC. Epidemiology of spontaneous abortion: the effects of alcohol consumption and cigarrette smoking. J. Nat. Med. Assoc. 78, 771-775 (1986
111. Parazzini F, Tozzi L, Chatenoud L, Restelli S, Luchini L, La ecchia C. Alcohol and risk of spontaneous abortion. Hum. Reprod. 9, 1950-1953 (1994
112. Homan G F, Davies M et al. The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Hum. Reprod. Update 13(3), 209-223 (2007
113. Donnelly G P, McClure N et al. Direct effect of alcohol on the motility and morphology of human spermatozoa. Andrologia 31(1), 43-47 (1999
114. Muthusami K R, Chinnaswamy P. Effect of chronic alcoholism on male fertility hormones and semen quality. Fertil. Steril. 84(4), 919-924 (2005
115. Klonoff-Cohen H, Bleha J et al A prospective study of the effects of female and male caffeine consumption on the reproductive end points of IVF and gamete intra-fallopian transfer. Hum. Reprod. 17(7), 1746-1754 (2002
116. Zaadstra BM, Looman CW et al. Moderate drinking: no impact on female fecundity. Fertil. Steril. 62, 948-954 (1994
117. Unuane D, Tournaye H, Velkeniers B, Poppe K. Endocrine disorders & female infertility. Best Pract. Res. Clin. Endocrinol. Metab. 25(6), 861-873 (2011
118. Regan L, Owen EJ, Jacobs HS. Hypersecretion of luteinising hormone, infertility and miscarriage. Lancet 336, 1141-1144 (1990
119. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilisation. Fertil. Steril. 77, 1148-1155. (2002
120. Poppe K, Glinoer D, Tournaye H et al. Thyroid autoimmunity and female infertility. Verh. K. Acad. Geneeskd. Belg. 68(5-6), 357-377 (2006
121. Boss EA, van Golde RJ, Beerendonk CC, Massuger LF. Pregnancy after radical trachelectomy: a real option?. Gynecol. Oncol. 99, 152-156 (2005
122. Oktay K, Buyuk E, Libertella N, Akar M, Rosenwaks Z. Fertility preservation in breast cancer patients: a prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation. J. Clin. Oncol. 23, 4347-4353 (2005
123. Fedele L, Arcaini L, Parazzini F, Vercellini P, Di Nola G. Reproductive prognosis after hysteroscopic metroplasty in 102 women: life-Table analysis. Fertil. Steril. 59, 768-772 (1993
124. Pabuccu R GV. Reproductive outcome after hysteroscopic metroplasty in women with septate uterus and otherwise unexplained infertility. Fertil. Steril. 81, 1675-1678 (2004
125. Raga F, Bauset C, Remohi J, Bonilla-Musoles F, Simon C, Pellicer A. Reproductive impact of congenital Mullerian anomalies. Hum. Reprod. 12, 2277-2281 (1997
126. Asherman JG. Traumatic intra-uterine adhesions. J. Obstet. Gynaecol. Br. 57, 892-896 (1950
127. Adoni A, Palti Z, Milwidsky A, Dolberg M. The incidence of intrauterine adhesions following spontaneous abortion. Int. J. Fertil. 27, 117-118 (1982
128. Bukulmez O, Yarali H, Gurgan T. Total corporal synechiae due to tuberculosis carry a very poor prognosis following hysteroscopic synechialysis. Hum. Reprod. 14, 1960-1961 (1999
129. Valli E, Zupi E, Marconi D et al. Hysteroscopic findings in 344 women with recurrent spontaneous abortion. J. Am. Assoc. Gynecol. Laparosc. 8, 398-401 (2001
130. Guimaraes Filho HA, Mattar R, Pires CR, Araujo Junior E, Moron AF, Nardozza LM. Comparison of hysterosalpingography, hysterosonography and hysteroscopy in evaluation of the uterine cavity in patients with recurrent pregnancy losses. Arch. Gynecol. Obstet. 274, 284-288 (2006
131. Taylor E, Gomel V. The uterus and fertility. Fertil. Steril. 89(1), 1-16 (2008
132. Sugiura-Ogasawara M, Lin BL, Aoki K et al. Does surgery improve live birth rates in patients with recurrent miscarriage caused by uterine anomalies?. J. Obstet. Gynaecol. 35(2), 155-158 (2015
133. Denson V. Diagnosis and management of infertility. J. Nurse Pract. 2(6), 380-386 (2006
134. The Practice Committee of the American Society of Reproductive Medicine. Aging and infertility in women. Fertil Steril. 82(Suppl. 1), S102-S106 (2004
135. Bigrigg MA RM Management of women referred to early pregnancy assessment unit: care and cost-effectiveness. 302, 577-579 (1991
136. Association of Early Pregnancy Assessment Units. Guidelines 2004 www.earlypregnancy.org.uk
137. Christiansen OB. Recurrent pregnancy loss. In: Gynecology in Practice. John Wiley and Sons, London, UK (2014
138. Lee H, McCulloh DH, Hodes-Wertz B, Adler A, McCaffrey C, Grifo JA. In vitro fertilization with preimplantation genetic screening improves implantation and live birth in women age 40 through 43. J. Assist. Reprod. Genet. 32(3), 435-444 (2015
139. Sermon K, Van Steirteghem A, Liebaers I. Preimplantation genetic diagnosis. Lancet 363(9421), 1633-1641 (2004
140. Porter TF, LaCoursiere Y, Scott JR. Immunotherapy for recurrent miscarriage. Cochrane Database Syst. Rev. (2) (2006
141. Wilczynski JR, Radwan P, Tchorzewski H, Banasik M. Immunotherapy of patients with recurrent spontaneous miscarriage and idiopathic infertility: does the immunization-dependent Th2 cytokine overbalance really matter?. Arch. Immunol. Ther. Exp. (Warsz) 60(2), 151-160 (2012
142. Empson M, Lassere M, Craig J, Scott J. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst. Rev. (2), CD002859 (2005
143. Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S. Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome. Cochrane Database Syst. Rev. (1), CD004734 (2009
144. Stern C, Chamley L. Antiphospholipid antibodies and coagulation defects in women with implantation failure after IVF and recurrent miscarriage. Reprod. Biomed. Online 13(1), 29-37 (2006
145. Seshadri S, Sunkara SK, Khalaf Y, El-Toukhy T, Hamoda H. Effect of heparin on the outcome of IVF treatment: a systematic review and meta-Analysis. Reprod. Biomed. Online 25(6), 572-584 (2012
146. Haas DM, Ramsey PS. Progestogen for preventing miscarriage. Cochrane Database Syst. Rev. 10, CD003511 (2013
147. Vissenberg R GM. Is there a role for assisted reproductive technology in recurrent miscarriage?. Semin. Reprod. Med. 29(6), 548-556 (2011