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Volumn 60, Issue 2, 2012, Pages 151-160

Immunotherapy of patients with recurrent spontaneous miscarriage and idiopathic infertility: Does the immunization-dependent Th2 cytokine overbalance really matter?

Author keywords

Cytokines; Idiopathic infertility; Paternal lymphocyte immunization; Recurrent spontaneous miscarriage

Indexed keywords

CD16 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; TUMOR NECROSIS FACTOR ALPHA;

EID: 84858705762     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-012-0161-6     Document Type: Article
Times cited : (27)

References (65)
  • 1
    • 38449094122 scopus 로고    scopus 로고
    • Association of abnormal vaginal flora with increased cervical tumour necrosis factoralpha and interferon-gamma levels in idiopathic infertility
    • Aboul Enien WM, El Metwally HA (2005) Association of abnormal vaginal flora with increased cervical tumour necrosis factoralpha and interferon-gamma levels in idiopathic infertility. Egypt J Immunol 12:53-59
    • (2005) Egypt J Immunol , vol.12 , pp. 53-59
    • Aboul Enien, W.M.1    El Metwally, H.A.2
  • 2
    • 84858704161 scopus 로고    scopus 로고
    • TGF-b1 gene polymorphism (position/509 C/T) in repeated spontaneous abortion (RSA)
    • Amani D, Samsami A, Zolghadri J et al (2003) TGF-b1 gene polymorphism (position/509 C/T) in repeated spontaneous abortion (RSA). J Reprod Immunol 58(10):2
    • (2003) J Reprod Immunol , vol.58 , Issue.10 , pp. 2
    • Amani, D.1    Samsami, A.2    Zolghadri, J.3
  • 3
    • 0034924990 scopus 로고    scopus 로고
    • Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy
    • DOI 10.1006/smim.2000.0319
    • Ashkar AA, Croy BA (2001) Functions of uterine natural killer cells are mediated by interferon gamma production during murine pregnancy. Semin Immunol 13:235-241 (Pubitemid 32664627)
    • (2001) Seminars in Immunology , vol.13 , Issue.4 , pp. 235-241
    • Ashkar, A.A.1    Croy, B.A.2
  • 4
    • 0034679718 scopus 로고    scopus 로고
    • Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity and uterine natural killer cell maturation during normal murine pregnancy
    • Ashkar AA, Di Santo J, Croy A (2000) Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity and uterine natural killer cell maturation during normal murine pregnancy. J Exp Med 192:259-270
    • (2000) J Exp Med , vol.192 , pp. 259-270
    • Ashkar, A.A.1    Di Santo, J.2    Croy, A.3
  • 6
    • 84858708632 scopus 로고    scopus 로고
    • Th-1/Th-2 natural killer cell activation systemically and locally in the endometrium and therapeutic options and outcome
    • Beer AE (2003) Th-1/Th-2 natural killer cell activation systemically and locally in the endometrium and therapeutic options and outcome. J Reprod Immunol 58:I.27
    • (2003) J Reprod Immunol , vol.58
    • Beer, A.E.1
  • 9
    • 77950617107 scopus 로고    scopus 로고
    • A practical approach to the prevention of miscarriage: Part 2-active immunotherapy
    • Check JH (2010)A practical approach to the prevention of miscarriage: part 2-active immunotherapy. Clin Exp Obstet Gynecol 37:5-9
    • (2010) Clin Exp Obstet Gynecol , vol.37 , pp. 5-9
    • Check, J.H.1
  • 10
    • 0036308580 scopus 로고    scopus 로고
    • Differential expression of interleukins (IL) IL-13 and IL-15 throughout the menstrual cycle in endometrium of normal fertile women and women with recurrent spontaneous abortion
    • DOI 10.1016/S0165-0378(02)00043-8, PII S0165037802000438
    • Chegini N, Ma C, Roberts M et al (2002) Differential expression of interleukins (IL) IL-13 and IL-15 throughout the menstrual cycle in endometrium of normal fertile women and women with recurrent spontaneous abortion. J Reprod Immunol 56:93-110 (Pubitemid 34754358)
    • (2002) Journal of Reproductive Immunology , vol.56 , Issue.1-2 , pp. 93-110
    • Chegini, N.1    Ma, C.2    Roberts, M.3    Williams R.Stan4    Ripps, B.A.5
  • 11
    • 77955960873 scopus 로고    scopus 로고
    • Elevated NK cell cytotoxicity, CD158a expression in NK cells and activated T lymphocytes in peripheral blood of women with IVF failures
    • Chernyshov VP, Sudoma IO, Don'skoi BV et al (2010) Elevated NK cell cytotoxicity, CD158a expression in NK cells and activated T lymphocytes in peripheral blood of women with IVF failures. Am J Reprod Immunol 64:58-67
    • (2010) Am J Reprod Immunol , vol.64 , pp. 58-67
    • Chernyshov, V.P.1    Sudoma, I.O.2    Don'Skoi, B.V.3
  • 12
    • 3343021161 scopus 로고    scopus 로고
    • Active or passive immunization in unexplained recurrent miscarriage
    • DOI 10.1016/j.jri.2003.09.003, PII S0165037804000348
    • Christiansen OB, Nielsen HS, Pedersen B (2004) Active or passive immunization in unexplained recurrent miscarriage. J Reprod Immunol 62:41-52 (Pubitemid 38993269)
    • (2004) Journal of Reproductive Immunology , vol.62 , Issue.1-2 , pp. 41-52
    • Christiansen, O.B.1    Nielsen, H.S.2    Pedersen, B.3
  • 13
    • 77952096811 scopus 로고    scopus 로고
    • Anti-TNFalpha therapy in immune-mediated subfertility: Atate of the art
    • Clark DA (2010) Anti-TNFalpha therapy in immune-mediated subfertility: atate of the art. J Reprod Immunol 85:15-24
    • (2010) J Reprod Immunol , vol.85 , pp. 15-24
    • Clark, D.A.1
  • 14
    • 13844254937 scopus 로고    scopus 로고
    • Loss of surface CD200 on stored allogeneic leukocytes may impair anti-abortive effect in vivo
    • Clark DA, Chaouat G (2005) Loss of surface CD200 on stored allogeneic leukocytes may impair anti-abortive effect in vivo. Am J Reprod Immunol 53:13-20
    • (2005) Am J Reprod Immunol , vol.53 , pp. 13-20
    • Clark, D.A.1    Chaouat, G.2
  • 15
    • 24944455211 scopus 로고    scopus 로고
    • Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans
    • DOI 10.1111/j.1600-0897.2005.00299.x
    • Clark DA, Blois S, Kandil J et al (2005) Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans. Am J Reprod Immunol 54:203-216 (Pubitemid 41309278)
    • (2005) American Journal of Reproductive Immunology , vol.54 , Issue.4 , pp. 203-216
    • Clark, D.A.1    Blois, S.2    Kandil, J.3    Handjiski, B.4    Manuel, J.5    Arck, P.C.6
  • 16
  • 19
    • 84858702487 scopus 로고    scopus 로고
    • Alloimmunization in patients with multiple pregnancy failures in IVF-ET
    • Drakakis P, Loutradis D, Makrigiannakis A et al (2003) Alloimmunization in patients with multiple pregnancy failures in IVF-ET. J Reprod Immunol 58(5):3
    • (2003) J Reprod Immunol , vol.58 , Issue.5 , pp. 3
    • Drakakis, P.1    Loutradis, D.2    Makrigiannakis, A.3
  • 20
    • 3042634797 scopus 로고    scopus 로고
    • Maternal serum levels of interferon-gamma and interleukin-2 soluble receptor-alpha predict the outcome of early IVF pregnacies
    • DOI 10.1093/humrep/deh169
    • Fasouliotis SJ, Spandorfer SD, Witkin SS et al (2004) Maternal serum levels of interferon-gamma and interleukin-2 soluble receptoralpha predict the outcome of early IVF pregnancies. Hum Reprod 19:1357-1363 (Pubitemid 38807708)
    • (2004) Human Reproduction , vol.19 , Issue.6 , pp. 1357-1363
    • Fasouliotis, S.J.1    Spandorfer, S.D.2    Schattman, G.3    Liu, H.C.4    Roberts, J.E.5    Rosenwaks, Z.6
  • 21
    • 39149123518 scopus 로고    scopus 로고
    • Effect of leukocyte therapy on tumor necrosis factor-alpha and interferon-gamma production in patients with recurrent spontaneous abortion
    • DOI 10.1111/j.1600-0897.2007.00569.x
    • Gharesi-Fard B, Zolghadri J, Kamali-Sarvestani E (2008) Effect of leukocyte therapy on tumor necrosis factor-alpha and interferongamma production in patients with recurrent spontaneous abortion. Am J Reprod Immunol 59:242-250 (Pubitemid 351250424)
    • (2008) American Journal of Reproductive Immunology , vol.59 , Issue.3 , pp. 242-250
    • Gharesi-Fard, B.1    Zolghadri, J.2    Kamali-Sarvestani, E.3
  • 22
    • 65949102692 scopus 로고    scopus 로고
    • Regulatory T-cells and immune tolerance in pregnancy: A new target for infertility treatment?
    • Guerin LR, Prins JR, Robertson SA (2009) Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update 15:517-535
    • (2009) Hum Reprod Update , vol.15 , pp. 517-535
    • Guerin, L.R.1    Prins, J.R.2    Robertson, S.A.3
  • 23
    • 60449084013 scopus 로고    scopus 로고
    • TH1-TH2 response and the atopy risk in patients with reproduction failure
    • Hanzlikova J, Ulcova-Gallova Z, Malkusova I et al (2009) TH1-TH2 response and the atopy risk in patients with reproduction failure. Am J Reprod Immunol 61:213-220
    • (2009) Am J Reprod Immunol , vol.61 , pp. 213-220
    • Hanzlikova, J.1    Ulcova-Gallova, Z.2    Malkusova, I.3
  • 25
    • 0029003434 scopus 로고
    • T helper 1-type cellular immunity to trophoblast in women with recurrent spontaneous abortions
    • Hill JA, Polgar K, Anderson DJ (1995) T helper 1-type cellular immunity to trophoblast in women with recurrent spontaneous abortions. JAMA 273:1933-1936
    • (1995) JAMA , vol.273 , pp. 1933-1936
    • Hill, J.A.1    Polgar, K.2    Anderson, D.J.3
  • 26
    • 0037339086 scopus 로고    scopus 로고
    • Analysis of intra-uterine cytokine concentration and matrix- metalloproteinase activity in women with recurrent failed embryo transfer
    • DOI 10.1093/humrep/deg139
    • Inagaki N, Stern C, McBain J et al (2003) Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer. Hum Reprod 18:608-615 (Pubitemid 36329334)
    • (2003) Human Reproduction , vol.18 , Issue.3 , pp. 608-615
    • Inagaki, N.1    Stern, C.2    McBain, J.3    Lopata, A.4    Kornman, L.5    Wilkinson, D.6
  • 27
    • 67649844319 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans
    • Kang HJ, Feng Z, Sun Y et al (2009) Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci USA 106:9761-9766
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 9761-9766
    • Kang, H.J.1    Feng, Z.2    Sun, Y.3
  • 29
    • 0037386353 scopus 로고    scopus 로고
    • Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF
    • DOI 10.1093/humrep/deg156
    • Kwak-Kim JY, Chung-Bang HS, Ng SC et al (2003) Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF. Hum Reprod 18:767-773 (Pubitemid 36426955)
    • (2003) Human Reproduction , vol.18 , Issue.4 , pp. 767-773
    • Kwak-Kim, J.Y.H.1    Chung-Bang, H.S.2    Ng, S.C.3    Ntrivalas, E.I.4    Mangubat, C.P.5    Beaman, K.D.6    Beer, A.E.7    Gilman-Sachs, A.8
  • 30
    • 4544238694 scopus 로고    scopus 로고
    • Detectable levels of interleukin-18 in uterine luminal secretions at oocyte retrieval predict failure of the embryo transfer
    • DOI 10.1093/humrep/deh356
    • Ledee-Bataille N, Olivennes F, Kadoch J et al (2004) Detectable levels of interleukin-18 in uterine luminal secretions at oocyte retrieval predict failure of the embryo transfer. Hum Reprod 19:1968-1973 (Pubitemid 39236460)
    • (2004) Human Reproduction , vol.19 , Issue.9 , pp. 1968-1973
    • Ledee-Bataille, N.1    Olivennes, F.2    Kadoch, J.3    Dubanchet, S.4    Frydman, N.5    Chaouat, G.6    Frydman, R.7
  • 31
    • 77957155777 scopus 로고    scopus 로고
    • Association between -238 but not -308 polymorphism of tumor necrosis factor alpha (TNF-alpha) and unexplained recurrent spontaneous abortion (URSA) in Chinese population
    • Liu C, Wang J, Zhou S et al (2010) Association between -238 but not -308 polymorphism of tumor necrosis factor alpha (TNF-alpha) and unexplained recurrent spontaneous abortion (URSA) in Chinese population. Reprod Biol Endocrinol 8:114
    • (2010) Reprod Biol Endocrinol , vol.8 , pp. 114
    • Liu, C.1    Wang, J.2    Zhou, S.3
  • 32
    • 0034794829 scopus 로고    scopus 로고
    • Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions
    • Makhseed M, Raghupathy R, Azizieh F et al (2001) Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 16:2219-2226 (Pubitemid 32951921)
    • (2001) Human Reproduction , vol.16 , Issue.10 , pp. 2219-2226
    • Makhseed, M.1    Raghupathy, R.2    Azizieh, F.3    Omu, A.4    Al-Shamali, E.5    Ashkanani, L.6
  • 33
    • 0031107660 scopus 로고    scopus 로고
    • Efficiency of lymphocyte immunization by the partner in prevention of unexplained recurrent spontaneous abortion. II. Immunologic prognostic factors
    • Malinowski A, Zeman K, Banasik M et al (1997) Efficiency of lymphocyte immunization by the partner in prevention of unexplained recurrent spontaneous abortion. II. Immunologic prognostic factors. Ginekol Pol 68:173-180
    • (1997) Ginekol Pol , vol.68 , pp. 173-180
    • Malinowski, A.1    Zeman, K.2    Banasik, M.3
  • 35
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: Tolerance and tryptophan catabolism
    • Mellor AM, Munn DH (2004) IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4:762-774
    • (2004) Nat Rev Immunol , vol.4 , pp. 762-774
    • Mellor, A.M.1    Munn, D.H.2
  • 36
    • 84858698292 scopus 로고    scopus 로고
    • Pregnancy and birth rate following immunotherapy in infertile women
    • Michelon T, Michelon J, Badalotti M et al (2003) Pregnancy and birth rate following immunotherapy in infertile women. J Reprod Immunol 58(5):1
    • (2003) J Reprod Immunol , vol.58 , Issue.5 , pp. 1
    • Michelon, T.1    Michelon, J.2    Badalotti, M.3
  • 37
    • 0141628381 scopus 로고    scopus 로고
    • - cells in total natural killer cells as an indication of fertility and infertility
    • DOI 10.1016/S0015-0282(03)00778-7
    • Michou VI, Kanavaros P, Athanassiou V et al (2003) Fraction of the peripheral blood concentration of CD56+/CD16-/CD3- cells in total natural killer cells as an indication of fertility and infertility. Fertil Steril 80(suppl 2):691-697 (Pubitemid 37152381)
    • (2003) Fertility and Sterility , vol.80 , Issue.SUPPL. 2 , pp. 691-697
    • Michou, V.I.1    Kanavaros, P.2    Athanassiou, V.3    Chronis, G.B.4    Stabamas, S.5    Tsilivakos, V.6
  • 38
    • 65949089008 scopus 로고    scopus 로고
    • Interferon gamma in successful pregnancies
    • Murphy SP, Tayade C, Ashkar AA et al (2009) Interferon gamma in successful pregnancies. Biol Reprod 80:848-859
    • (2009) Biol Reprod , vol.80 , pp. 848-859
    • Murphy, S.P.1    Tayade, C.2    Ashkar, A.A.3
  • 40
    • 1542302654 scopus 로고    scopus 로고
    • Induction of MLR-Bf and protection of fetal loss: A current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion
    • DOI 10.1016/j.intimp.2004.01.001, PII S1567576904000037
    • Pandey MK, Agrawal S (2004) Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion. Int Immunopharmacol 4:289-298 (Pubitemid 38296357)
    • (2004) International Immunopharmacology , vol.4 , Issue.2 , pp. 289-298
    • Pandey, M.K.1    Agrawal, S.2
  • 41
    • 1642307910 scopus 로고    scopus 로고
    • Lymphocyte immunotherapy and its probable mechanism in the maintenance of pregnancy in women with recurrent spontaneous abortion
    • DOI 10.1007/s00404-003-0560-3
    • Pandey MK, Thakur S, Agrawal S (2004) Lymphocyte immunotherapy and its probable mechanism in the maintenance of pregnancy in women with recurrent spontaneous abortion. Arch Gynecol Obstet 269:161-172 (Pubitemid 38374702)
    • (2004) Archives of Gynecology and Obstetrics , vol.269 , Issue.3 , pp. 161-172
    • Pandey, M.K.1    Thakur, S.2    Agrawal, S.3
  • 42
    • 0028842260 scopus 로고
    • Synthesis and granular localization of tumor necrosis factor-alpha in activated NK cells in the pregnant mouse uterus
    • Parr EL, Chen HL, Parr MB et al (1995) Synthesis and granular localization of tumor necrosis factor-alpha in activated NK cells in the pregnant mouse uterus. J Reprod Immunol 28:31-40
    • (1995) J Reprod Immunol , vol.28 , pp. 31-40
    • Parr, E.L.1    Chen, H.L.2    Parr, M.B.3
  • 43
    • 57449101121 scopus 로고    scopus 로고
    • Uterine DCs are crucial for decidua formation during embryo implantation in mice
    • Plaks V, Birnberg T, Berkutzki T et al (2008) Uterine DCs are crucial for decidua formation during embryo implantation in mice. J Clin Invest 118:3954-3965
    • (2008) J Clin Invest , vol.118 , pp. 3954-3965
    • Plaks, V.1    Birnberg, T.2    Berkutzki, T.3
  • 45
    • 55449107148 scopus 로고    scopus 로고
    • Definitions of infertility and recurrent pregnancy loss
    • Practice Committee of the American Society for Reproductive Medicine
    • Practice Committee of the American Society for Reproductive Medicine (2008) Definitions of infertility and recurrent pregnancy loss. Fertil Steril 90(5 suppl):S60
    • (2008) Fertil Steril , vol.90 , Issue.5 SUPPL.
  • 46
    • 0034008633 scopus 로고    scopus 로고
    • Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion
    • Raghupathy R, Makhseed M, Azizieh F et al (2000) Cytokine production by maternal lymphocytes during normal pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod 15:713-718 (Pubitemid 30142390)
    • (2000) Human Reproduction , vol.15 , Issue.3 , pp. 713-718
    • Raghupathy, R.1    Makhseed, M.2    Azizieh, R.3    Omu, A.4    Gupta, M.5    Farhat, R.6
  • 47
    • 0033865823 scopus 로고    scopus 로고
    • Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion?
    • Ramhorst R, Agriello E, Zittermann S et al (2000) Is the paternal mononuclear cells' immunization a successful treatment for recurrent spontaneous abortion? Am J Reprod Immunol 44:129-135
    • (2000) Am J Reprod Immunol , vol.44 , pp. 129-135
    • Ramhorst, R.1    Agriello, E.2    Zittermann, S.3
  • 50
    • 0037339109 scopus 로고    scopus 로고
    • Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: An intracellular flow cytometric analysis of peripheral blood mononuclear cells
    • DOI 10.1046/j.1365-2249.2003.02082.x
    • Sacks GP, Redman CW, Sargent IL (2003) Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells. Clin Exp Immunol 131:490-497 (Pubitemid 36324141)
    • (2003) Clinical and Experimental Immunology , vol.131 , Issue.3 , pp. 490-497
    • Sacks, G.P.1    Redman, C.W.G.2    Sargent, I.L.3
  • 51
    • 16244399547 scopus 로고    scopus 로고
    • high regulatory T cells in human pregnancy
    • DOI 10.1016/j.jri.2005.01.004
    • Saito S, Sasaki Y, Sakai M (2005) CD4 + CD25 high regulatory T cells in human pregnancy. J Reprod Immunol 65:111-120 (Pubitemid 40461929)
    • (2005) Journal of Reproductive Immunology , vol.65 , Issue.2 , pp. 111-120
    • Saito, S.1    Sasaki, Y.2    Sakai, M.3
  • 52
    • 77954295316 scopus 로고    scopus 로고
    • Natural selection of human embryos: Impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
    • Salker M, Teklenburg G, Molokhia M et al (2010) Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One 5:e10287
    • (2010) PLoS One , vol.5
    • Salker, M.1    Teklenburg, G.2    Molokhia, M.3
  • 53
    • 44949205416 scopus 로고    scopus 로고
    • In infertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-gamma, interleukin-10 and tumor necrosis factoralpha upon heat shock protein stimulation than fertile women
    • Srivastava P, Jha R, Bas S et al (2008) In infertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-gamma, interleukin-10 and tumor necrosis factoralpha upon heat shock protein stimulation than fertile women. Reprod Biol Endocrinol 6:20
    • (2008) Reprod Biol Endocrinol , vol.6 , pp. 20
    • Srivastava, P.1    Jha, R.2    Bas, S.3
  • 54
    • 0025998420 scopus 로고
    • A possible mechanism of immunotherapy for patients with recurrent spontaneous abortions
    • Sugi T, Makino T, Maruyama T et al (1991) A possible mechanism of immunotherapy for patients with recurrent spontaneous abortions. Am J Reprod Immunol 25:185-189
    • (1991) Am J Reprod Immunol , vol.25 , pp. 185-189
    • Sugi, T.1    Makino, T.2    Maruyama, T.3
  • 55
    • 0034950376 scopus 로고    scopus 로고
    • The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice
    • DOI 10.1016/S0165-0378(01)00065-1, PII S0165037801000651
    • Svensson L, Arvola M, Sallstrom RH et al (2001) The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice. J Reprod Immunol 51:3-7 (Pubitemid 32594861)
    • (2001) Journal of Reproductive Immunology , vol.51 , Issue.1 , pp. 3-7
    • Svensson, L.1    Arvola, M.2    Sallstrom, M.-A.3    Holmdahl, R.4    Mattsson, R.5
  • 56
    • 0035754135 scopus 로고    scopus 로고
    • The influence of paternal lymphocytes immunization on percentage of peripheral blood CD16+/CD56+ cells in women with primary recurrent spontaneous abortion
    • Szpakowski A, Malinowski A, Zeman K et al (2001) The influence of paternal lymphocytes immunization on percentage of peripheral blood CD16+/CD56+ cells in women with primary recurrent spontaneous abortion. Ginekol Pol 72:1063-1068
    • (2001) Ginekol Pol , vol.72 , pp. 1063-1068
    • Szpakowski, A.1    Malinowski, A.2    Zeman, K.3
  • 57
    • 7944230300 scopus 로고    scopus 로고
    • Diagnosis and treatment of recurrent miscarriage associated with immunologic disorders: Is paternal lymphocyte immunization the relic of the past?
    • Takeshita T (2004) Diagnosis and treatment of recurrent miscarriage associated with immunologic disorders: is paternal lymphocyte immunization the relic of the past? J Nihon Med Sch 71:308-313
    • (2004) J Nihon Med Sch , vol.71 , pp. 308-313
    • Takeshita, T.1
  • 59
    • 77952092573 scopus 로고    scopus 로고
    • Recurrent miscarriage: Current concepts in diagnosis and treatment
    • Toth B, Jeschke U, Rogenhofer N et al (2010) Recurrent miscarriage: current concepts in diagnosis and treatment. J Reprod Immunol 85:25-32
    • (2010) J Reprod Immunol , vol.85 , pp. 25-32
    • Toth, B.1    Jeschke, U.2    Rogenhofer, N.3
  • 60
    • 0027207375 scopus 로고
    • Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a T(H)2 phenomenon?
    • DOI 10.1016/0167-5699(93)90235-D
    • Wegmann TG, Lin H, Guilbert L et al (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today 14:353-356 (Pubitemid 23198169)
    • (1993) Immunology Today , vol.14 , Issue.7 , pp. 353-356
    • Wegmann, T.G.1    Lin, H.2    Guilbert, L.3    Mosmann, T.R.4
  • 61
    • 58249141891 scopus 로고    scopus 로고
    • Treatment with adalimumab (Humira) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF
    • Winger EE, Reed JL, Ashoush S et al (2009) Treatment with adalimumab (Humira) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF. Am J Reprod Immunol 61:113-120
    • (2009) Am J Reprod Immunol , vol.61 , pp. 113-120
    • Winger, E.E.1    Reed, J.L.2    Ashoush, S.3
  • 62
    • 67649094934 scopus 로고    scopus 로고
    • Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients
    • Yang H, Qiu L, Di W et al (2008) Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients. Fertil Steril 92:301-305
    • (2008) Fertil Steril , vol.92 , pp. 301-305
    • Yang, H.1    Qiu, L.2    Di, W.3
  • 63
    • 33646079873 scopus 로고    scopus 로고
    • Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband's mononuclear cells
    • Yokoo T, Takakuwa K, Ooki I et al (2006) Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with the husband's mononuclear cells. Fertil Steril 85:1452-1457
    • (2006) Fertil Steril , vol.85 , pp. 1452-1457
    • Yokoo, T.1    Takakuwa, K.2    Ooki, I.3
  • 64
    • 0036785047 scopus 로고    scopus 로고
    • Questioning the Th1/Th2 paradigm in reproduction: Peripheral levels of IL-12 are downregulated in miscarriage patients
    • Zenclussen AC, Fest S, Busse P et al (2002) Questioning the Th1/Th2 paradigm in reproduction: peripheral levels of IL-12 are downregulated in miscarriage patients. Am J Reprod Immunol 48:245-251
    • (2002) Am J Reprod Immunol , vol.48 , pp. 245-251
    • Zenclussen, A.C.1    Fest, S.2    Busse, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.