Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion

Human Reproduction

Volumn 15, Issue 3, 2000, Pages 713-718

  Raghupathy, R ^a   Makhseed, M ^a   Azizieh, R ^a   Omu, A ^a   Gupta, M ^b   Farhat, R ^b  

^a KUWAIT UNIVERSITY   (Kuwait)

^b AL SABAH HOSPITAL   (Kuwait)

Author keywords

Cytokines; Recurrent abortions; T helper 1; T helper 2

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; IDIOPATHIC DISEASE; RECURRENT ABORTION; SPONTANEOUS ABORTION; TH1 CELL; TH2 CELL;

EID: 0034008633     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/15.3.713     Document Type: Article

References (29)

1. Ashworth, F. (1992) Septic abortion. In Stabile, I., Gmdzinskas, G. and Chard, T. (eds), Spontaneous Abortion: Diagnosis and Treatment. Springer-Verlag, London, p. 119.
2. Baines, M.G., Duclos, A.J., Antecka, E. and Haddad, E.K. (1997) Decidual infiltration and activation of macrophages leads to early embryo loss. Am. J. Reprod. ImmunoL, 37, 471-479.
3. Bennett, M.J. (1987) Congenital abnormalities of the fundus. In Bennett, M.J. and Edmonds, O.K. (eds), Spontaneous and Recurrent Abortion. Blackwell, Oxford, p. 109.
4. Berkowitz, R., Hill, J.A., Kurtz, C.B. and Andersen, D.J. (1988) Effects of products of activated leukocytes (lymphokines and monokines) on the growth of malignant trophoblast cells in vitro. Am. J. Obstet. Gynecol., 151, 199-203.
5. Chaouat, G., Menu, E., Clark, D.A. et al. (1990) Control of fetal survival in CBAxDBA/2 mice by lymphokine therapy. J. Reprod. Fertil, 89, 447-458.
6. Chaouat, G., Meliani, A.A., Mortal, J. et al. (1995) IL-10 prevents naturally occurring fetal loss in the CBAxDBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by m vitro injection of IFN-T. J. Immunol, 15-4, 4261-4268.
7. Clark, D.A., Chaouat, G., Arck, P.C. et al. (1998) Cytokine-dependent abortions in CBAxDBA/2 mice is mediated by the procoagulin fg12 pathway. J. Immunol, 160, 545-554.
8. Ecker, J.L., Laufer, M.R. and Hill, J.A. (1993) Measurement of embryotoxic factors is predictive of pregnancy outcome in women with history of recurrent abortion. Obstet. Gynecol, SI, 84-87.
9. Gendron, R.L. and Baines, M. (1988) Immunohistological analyses of decidual natural killer cells during spontaneous abortions in mice. Cell. Immunol, 113, 261-267.
10. Haddad, E.K., Duclos, A.J. and Baines, M.G. (1995) Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells. J. Exp. Med., 185, 1143-1151.
11. Hill, J.A. (1992) Immunologie mechanisms of pregnancy maintenance and failure: a critique of theories and therapy. Am. J. Reprod. Immunol., 22, 33-42.
12. Hill, J.A. (1995) Immunologie factors in recurrent spontaneous abortions. In Kurpisz, M. and Femandez, N. (eds), Immunology of Human Reproduction. BIOS, Oxford, pp. 401-424.
13. Hill, J.A., Anderson, D.J. and Polgar, K. (1995) T helper 1-type cellular immunity to trophoblast in women with recurrent spontaneous abortions. J. Am. Med. Assoc., 273, 1933-1958.
14. Kilpatrick, L. (1999) Influence of human leukocyte antigens and tumor necrosis factor genes in the development of pre-eclampsia. Hum. Reprod. Update, 5, 94-102.
15. Kinsky, R., Delage, G., Rosin, M. et al. (1990) A murine model of NK cell mediated résorption. Am. J. Reprod. [inmunol., 23, 73-77.
16. Krishnan, L., Guilbert, L.J., Wegmann, T.G. et al. (1996) T helper 1 response against Leishmania major in pregnant C57BL6 mice increases implantation failure and fetal résorptions. J. limmmol., 156, 653-662.
17. Makhseed, M., Raghupathy, R., Azizieh, F. et al. (1999) Mitogen-induced cytokine responses of maternal peripheral blood lymphocytes indicate a differential Th-bias in normal pregnancy and pregnancy failure. Am. J. Reprod. Immunol, 42, 273-281.
18. Marzi, M., Vigano, A., Trabattoni, D. et al. (1996) Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin. Exp. Immunol., 106, 127-133.
19. Mosmann, T.R. and Coffman, R.L. (1989) Thl and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Anna. Rev. Immunol., 7, 145-173.
20. Mosmann, T.R. and Sad, S. (1996) The expanding universe of T-cell subsets. Immunol. Today, 17, 138-46.
21. Piccinni, M.-R, Beloni, L., Livi, C. et al. (1998) Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nature Med., 4, 1020-1024.
22. Portnoi, M.F., Joye, N., Vanden Akker, J. et al. (1988) Karyotypes of 1142 couples with recurrent abortion. Obstet. Gynecol, 72, 31-42.
23. Raghupathy, R. (1997) Thl-type immunity is incompatible with successful pregnancy. Imnumol. Today, 18, 478-482.
24. Raghupathy, R., Makhseed, M., Azizieh, F. et al. (1999) Maternal Thl- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell. Immunol., 196, 122-130.
25. Romagnani, S. (1994) Lymphokine production by human T cells in disease states. Anna. Rev. Immunol., 12, 227-257.
26. Somigliana, E., Vigano, P. and Vignali, M. (1999) Endometriosis and unexplained recurrent abortion: pathological states resulting from aberrant modulation of natural killer function? Hum. Reprod. Update, 5, 40-51.
27. Stray-Pederson, B. and Stray-Pederson, S. (1984) Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am. J. Obstet. Gynecol, 148, 140-151.
28. Wegmann, T.G., Lin, H., Guilbert, L. and Mosmann, T.R. (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol. Today, 14, 353-356.
29. Yui, J., Garcia-Lloret, M., Wegmann, T.G. and Guilbert, L.J. (1994) Cytotoxicity of tumor necrosis factor-a (TNF-a) and gamma-interferon (IFN-y) against primary human placental trophoblasts. Placenta, 15, 819-826.