Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection

ACS Chemical Neuroscience

Volumn 6, Issue 8, 2015, Pages 1309-1316

  Biswas, Atanu ^a   Kurkute, Prashant ^a   Saleem, Suraiya ^b   Jana, Batakrishna ^a   Mohapatra, Saswat ^a   Mondal, Prasenjit ^a   Adak, Anindyasundar ^a   Ghosh, Subhajit ^a   Saha, Abhijit ^a   Bhunia, Debmalya ^a   Biswas, Subhash Chandra ^b   Ghosh, Surajit ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

A 42 peptide; microtubule; neuroprotective peptide; PC12 cell; tubulin

Indexed keywords

AMYLOID BETA PROTEIN; ASPARAGINYLALANYLVALYSERYLISOLEUCYLGLUTAMINE; BETA TUBULIN; HEXAPEPTIDE; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG; AMYLOID BETA-PROTEIN (1-42); ASN-ALA-VAL-SER-ILE-GLN; OLIGOPEPTIDE; PEPTIDE FRAGMENT;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; CELL VIABILITY ASSAY; CONTROLLED STUDY; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MOLECULAR DYNAMICS; NEUROPROTECTION; NONHUMAN; PC12 CELL LINE; PEPTIDE SYNTHESIS; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RAT; ANIMAL; BRAIN; CELL SURVIVAL; CHEMISTRY; CIRCULAR DICHROISM; CONFOCAL MICROSCOPY; GOAT; INFRARED SPECTROSCOPY; METABOLISM; MICROTUBULE; MOLECULAR DOCKING; PRECLINICAL STUDY; PROTEIN SECONDARY STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; CELL SURVIVAL; CIRCULAR DICHROISM; DRUG EVALUATION, PRECLINICAL; GOATS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; PC12 CELLS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; RATS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TUBULIN;

EID: 84939803447     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00149     Document Type: Article

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