Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 4269-4277

  Ha, Eun Sol ^a   Kim, Jeong Soo ^b   Baek, In Hwan ^c   Yoo, Jin Wook ^a   Jung, Yunjin ^a   Moon, Hyung Ryong ^a   Kim, Min Soo ^a  

^a Pusan National University   (South Korea)

^b Dong A ST Co Ltd   (South Korea)

^c Kyungsung University   (South Korea)

Author keywords

Bioavailability; Dissolution; Megestrol acetate; Supercritical technology

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; MEGESTROL ACETATE; NANOPARTICLE; POLYMER; POVIDONE; RYOTO SUGAR ESTER L1695; SURFACTANT; TOCOFERSOLAN; UNCLASSIFIED DRUG; ALPHA TOCOPHEROL; MACROGOL DERIVATIVE; PROGESTERONE DERIVATIVE;

ANALYZER; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALORIMETRY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; HYDROPHILICITY; IN VITRO STUDY; MALE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; RAT; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; CHEMISTRY; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; NANOTECHNOLOGY; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; POWDER DIFFRACTION; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT; SUPERCRITICAL FLUID CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, SUPERCRITICAL FLUID; CRYSTALLOGRAPHY, X-RAY; HYPROMELLOSE DERIVATIVES; INTESTINAL ABSORPTION; MALE; MEGESTROL ACETATE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; NANOTECHNOLOGY; POLYETHYLENE GLYCOLS; POVIDONE; POWDER DIFFRACTION; PROGESTERONE CONGENERS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; VITAMIN E;

EID: 84939789568     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S90706     Document Type: Article

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