Effect of physiochemical variables on phase solubility and dissolution behavior of indomethacin solid dispersion system

Journal of Pharmaceutical Investigation

Volumn 44, Issue 3, 2014, Pages 147-162

  Palanisamy, Mohanraj ^a,b   Khanam, Jasmina ^a  

^a JADAVPUR UNIVERSITY   (India)

^b Nandha College of Technology   (India)

Author keywords

Dissolution; Indomethacin; Phase solubility; Solid dispersion; Solid state studies

Indexed keywords

BETA CYCLODEXTRIN; CREMOPHOR; DRUG CARRIER; INDOMETACIN; MACROGOL 4000; POLOXAMER; POVIDONE;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DOSAGE FORM; DRUG RELEASE; DRUG SOLUBILITY; EVAPORATION; INFRARED SPECTROSCOPY; KNEADING TECHNIQUE; MELTING METHOD; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOLID DISPERSION SYSTEM; SOLID STATE; TEMPERATURE; X RAY DIFFRACTION;

EID: 84901407468     PISSN: 20935552     EISSN: 20936214     Source Type: Journal    
DOI: 10.1007/s40005-013-0111-2     Document Type: Article

References (25)

1. Bley H, Fussnegger B, Bodmeier R (2010) Characterization and stability of solid dispersions based on PEG/polymer blends. Int J Pharm 390: 165-173.
2. Chieng N, Aaltonen J, Saville D, Rades T (2009) Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. Eur J Pharm Biopharm 71: 47-54.
3. Chowdary KPR, Babu KVVS (1994) Dissolution, bioavailability and ulcerogenic studies on solid dispersions of indomethacin in water soluble cellulose polymers. Drug Dev Ind Pharm 20: 799-813.
4. Das NG, Das SK (2006) Formulation of poorly soluble drugs. Technol Overv Summer 52-55.
5. Engers D, Teng J, Novoa JJ, Gent P, Hossack S, Campbell C, Thomson J, Ivanisevic I, Templeton A, Byrn S, Newman A (2010) A solid-state approach to enable early development compounds: selection and animal bioavailability studies of an itraconazole amorphous solid dispersion. J Pharm Sci 99: 3901-3922.
6. Fernandes CM, Vieira MT, Veiga FJB (2002) Physicochemical characterization and in vitro dissolution behavior of nicardipine-cyclodextrins inclusion compounds. Eur J Pharm Sci 15: 79-88.
7. Higuchi T, Connors A (1965) Phase solubility techniques. Adv Anal Chem Instrum 4: 117-211.
8. Indian Pharmacopoeia (2007) Published by Government of India. I: 1227-1228.
9. Jambhekar S, Casella R, Maher T (2004) The physicochemical characteristics and bioavailability of indomethacin from β-cyclodextrin, hydroxyethyl-β-cyclodextrin, and hydroxypropyl-β-cyclodextrin complexes. Int J Pharm 270: 149-166.
10. Janssens S, Nagels S, Armas HND, Autry WD, Schepdael AV, Mooter GV (2008) Formulation and characterization of ternary solid dispersions made up of Itraconazole and two excipients, TPGS 1000 and PVPVA 64 that were selected based on a supersaturation screening study. Eur J Pharm Biopharm 69: 58-166.
11. Liu L, Wang X (2007) Improved dissolution of oleanolic acid with ternary solid dispersions. AAPS PharmSciTech 8: Article 113.
12. Marques HMC, Hadgraft J, Kellaway IW (1990) Studies of cyclodextrin inclusion complexes. I. The salbutamol-cyclodextrin complex as studied by phase solubility and DSC. Int J Pharm 63: 259-266.
13. Mooter GV, Augustijns P, Blaton N, Kinget R (1998) Physico-chemical characterization of solid dispersions of temazepam with polyethylene glycol 6000 and PVP K30. Int J Pharm 164: 67-80.
14. Mura P, Faucci MT, Bettinetti GP (2001) The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-β-cyclodextrin. Eur J Pharm Sci 13: 187-194.
15. Palanisamy M, Khanam J (2011) Solid dispersion of prednisolone: solid state characterization and improvement of dissolution profile. Drug Dev Ind Pharm 37: 373-386.
16. Paradkar A, Ambike AA, Jadhav BK, Mahadik KR (2004) Characterization of curcumin-PVP solid dispersion obtained by spray drying. Int J Pharm 271: 281-286.
17. Raju YP, Garbhapu A, Prasanna SAL, Rao BS, Murthy KVR (2007) Studies on enhancement of dissolution rate of etoposide. Ind J Pharm Sci 69: 269-273.
18. Ren F, Jing Q, Tang Y, Shen Y, Chen J, Gao F, Cui J (2006) Characteristics of bicalutamide solid dispersions and improvement of the dissolution. Drug Dev Ind Pharm 32: 967-972.
19. Sethia S, Squillante E (2004) Solid dispersion of carbamazepine in PVP K30 by conventional solvent evaporation and supercritical methods. Int J Pharm 272: 1-10.
20. Sugano K, Okazaki A, Sugimoto S, Tavornvipas S, Omura A, Mano T (2007) Solubility and dissolution profile assessment in drug discovery. Drug Metab Pharmacokinet 22: 225-254.
21. Sweetman SC (2005) Martindale: the complete drug reference. Pharmaceutical Press, London.
22. Veiga MD, Escobar C, Bernad MJ (1993) Dissolution behavior of drugs from binary and ternary systems. Int J Pharm 93: 215-220.
23. Wang S, Ding Y, Yao Y (2009) Inclusion complexes of fluorofenidone with β-cyclodextrin and hydroxypropyl-β-cyclodextrin. Drug Dev Ind Pharm 35: 808-813.
24. Weuts I, Kempen D, Decorte A, Verreck G, Peeters J, Brewster M, van den Mooter G (2004) Phase behavior analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP K30 and PVP-VA64. Eur J Pharm Sci 22: 375-385.
25. Wulff M, Alden M (1999) Solid state studies of drug-cyclodextrin inclusion complexes in PEG 6000 prepared by a new method. Eur J Pharm Sci 8: 269-281.