Improved oral absorption of dutasteride via Soluplus®-based supersaturable self-emulsifying drug delivery system (S-SEDDS)

International Journal of Pharmaceutics

Volumn 478, Issue 1, 2015, Pages 341-347

  Lee, Dong Hoon ^a   Yeom, Dong Woo ^a   Song, Ye Seul ^a   Cho, Ha Ra ^b   Choi, Yong Seok ^b   Kang, Myung Joo ^b   Choi, Young Wook ^a  

^a Chung Ang University   (South Korea)

^b Dankook University   (South Korea)

Author keywords

Bioavailability; drug delivery system; Dutasteride; Oral absorption; Soluplus ; Supersaturable self emulsifying

Indexed keywords

CAPROLACTAM; CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; DUTASTERIDE; EMULSIFYING AGENT; MACROGOL; POLYVINYL ACETATE; EMULSION; MACROGOL DERIVATIVE; POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMER; POLYVINYL DERIVATIVE; STEROID 5ALPHA REDUCTASE INHIBITOR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CRYSTALLIZATION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRECIPITATION; RAT; STOMACH JUICE; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; CHEMISTRY; EMULSION; INTESTINE ABSORPTION; ORAL DRUG ADMINISTRATION; SOLUBILITY; SPRAGUE DAWLEY RAT;

5-ALPHA REDUCTASE INHIBITORS; ADMINISTRATION, ORAL; ANIMALS; DRUG DELIVERY SYSTEMS; DUTASTERIDE; EMULSIONS; INTESTINAL ABSORPTION; MALE; POLYETHYLENE GLYCOLS; POLYVINYLS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84918783816     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.11.060     Document Type: Article

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