Preparation and evaluation of solid dispersion of atorvastatin calcium with soluplus® by spray drying technique

Chemical and Pharmaceutical Bulletin

Volumn 62, Issue 6, 2014, Pages 545-551

  Ha, Eun Sol ^a   Baek, In Hwan ^b   Cho, Wonkyung ^c,d   Hwang, Sung Joo ^d   Kim, Min Soo ^a  

^a Pusan National University   (South Korea)

^b Kyungsung University   (South Korea)

^c Chungnam National University   (South Korea)

^d Yonsei University   (South Korea)

Author keywords

Amorphous; Atorvastatin; Solid dispersion; Soluplus ; Supersaturation

Indexed keywords

ATORVASTATIN; DRUG CARRIER; POLYMER; SOLUPLUS; UNCLASSIFIED DRUG; HEPTANOIC ACID DERIVATIVE; MACROGOL DERIVATIVE; POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMER; POLYVINYL DERIVATIVE; PYRROLE DERIVATIVE; WATER;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SOLUBILITY; GASTROINTESTINAL TRACT; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOKINETICS; PHYSICAL CHEMISTRY; RAT; SOLID DISPERSION FORMULATION; SPRAY DRYING; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; DESICCATION; DRUG EFFECTS; ORAL DRUG ADMINISTRATION; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DESICCATION; HEPTANOIC ACIDS; MALE; POLYETHYLENE GLYCOLS; POLYVINYLS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; WATER;

EID: 84903398296     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c14-00030     Document Type: Article

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