Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe

Chemistry and Biology

Volumn 22, Issue 8, 2015, Pages 1002-1007

  Zheng, Qingfei ^a   Wang, Qinglan ^b   Wang, Shoufeng ^a   Wu, Jiequn ^c   Gao, Qian ^b   Liu, Wen ^a,c  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b FUDAN UNIVERSITY   (China)

^c Huzhou Center of Bio Synthetic Innovation   (China)

Author keywords

[No Author keywords available]

Indexed keywords

12' METHYL THIOSTREPTON; 3 AP ME; 5' FLUORO THIOSTREPTON; 6' FLUORO THIOSTREPTON; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; ERYTHROMYCIN; ISONIAZID; PROTEASOME INHIBITOR; RAPAMYCIN; THIOSTREPTON; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; QUINALDIC ACID; QUINOLINE DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; AUTOPHAGY; BACTERIAL LOAD; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENDOPLASMIC RETICULUM STRESS; HOST PATHOGEN INTERACTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; MYCOBACTERIUM MARINUM; PHYSIOLOGICAL STRESS; RAW 264.7 CELL LINE; SYNTHESIS; ZEBRA FISH;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM MARINUM;

ANIMALS; ANTI-BACTERIAL AGENTS; AUTOPHAGY; ENDOPLASMIC RETICULUM STRESS; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; MYCOBACTERIUM MARINUM; QUINOLINES; RAW 264.7 CELLS; STRESS, PHYSIOLOGICAL; THIOSTREPTON; ZEBRAFISH;

EID: 84939650896     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.06.019     Document Type: Article

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