Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish

Nature Protocols

Volumn 8, Issue 6, 2013, Pages 1114-1124

  Takaki, Kevin ^a   Davis, J Muse ^a   Winglee, Kathryn ^a   Ramakrishnan, Lalita ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATED PLATE FLUORIMETRY; BACTERIAL LOAD; BRAIN VENTRICLE; CAUDAL VEIN; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; FLUORESCENCE MICROSCOPY; FLUOROMETRY; HOST PATHOGEN INTERACTION; IN VIVO STUDY; INJECTION SITE; LARVA; MYCOBACTERIOSIS; MYCOBACTERIUM MARINUM INFECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RHOMBENCEPHALON; SURVIVAL; VEIN; ZEBRA FISH;

ANIMAL HUSBANDRY; ANIMALS; ANTITUBERCULAR AGENTS; DISEASE MODELS, ANIMAL; FLUOROMETRY; LARVA; MACROPHAGES; MICROSCOPY, FLUORESCENCE; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; PHAGOCYTOSIS; ZEBRAFISH;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; DANIO RERIO; MYCOBACTERIUM MARINUM;

EID: 84879396902     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2013.068     Document Type: Article

References (30)

1. Ramakrishnan, L. Revisiting the role of the granuloma in tuberculosis. Nat. Rev. Immunol. 12, 352-366 (2012).
2. Davis, J.M. et al. Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafsh embryos. Immunity 17, 693-702 (2002).
3. Clay, H. et al. Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafsh. Cell Host Microbe 2, 29-39 (2007).
4. Davis, J.M. & Ramakrishnan, L. The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell 136, 37-49 (2009).
5. Volkman, H.E. et al. Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant. PLoS Biol. 2, e367 (2004).
6. Volkman, H.E. et al. Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium. Science 327, 466-469 (2010).
7. Cosma, C.L., Klein, K., Kim, R., Beery, D. & Ramakrishnan, L. Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival. Infect. Immun. 74, 3125-3133 (2006).
8. Herbomel, P., Thisse, B. & Thisse, C. Ontogeny and behaviour of early macrophages in the zebrafsh embryo. Development 126, 3735-3745 (1999).
9. Yang, C.T. et al. Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe 12, 301-312 (2012).
10. Brannon, M.K. et al. Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafsh embryos. Cell Microbiol. 11, 755-768 (2009).
11. Neely, M.N., Pfeifer, J.D. & Caparon, M. Streptococcus-zebrafsh model of bacterial pathogenesis. Infect. Immun. 70, 3904-3914 (2002).
12. Ludwig, M. et al. Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafsh larvae. PLoS Pathog. 7, e1001269 (2011).
13. Phelan, P.E. et al. Characterization of snakehead rhabdovirus infection in zebrafsh (Danio rerio). J. Virol. 79, 1842-1852 (2005).
14. Lu, M.W. et al. The interferon response is involved in nervous necrosis virus acute and persistent infection in zebrafsh infection model. Mol. Immunol. 45, 1146-1152 (2008).
15. Chao, C.C. et al. Zebrafsh as a model host for Candida albicans infection. Infect. Immun. 78, 2512-2521 (2010).
16. Burgos, J.S., Ripoll-Gomez, J., Alfaro, J.M., Sastre, I. & Valdivieso, F. Zebrafsh as a new model for herpes simplex virus type 1 infection. Zebrafsh 5, 323-333 (2008).
17. Davis, J.M., Haake, D.A. & Ramakrishnan, L. Leptospira interrogans stably infects zebrafsh embryos, altering phagocyte behavior and homing to specifc tissues. PLoS Negl. Trop. Dis. 3, e463 (2009).
18. Pham, L.N., Kanther, M., Semova, I. & Rawls, J.F. Methods for generating and colonizing gnotobiotic zebrafsh. Nat. Protoc. 3, 1862-1875 (2008).
19. Haldi, M., Ton, C., Seng, W.L. & McGrath, P. Human melanoma cells transplanted into zebrafsh proliferate, migrate, produce melanin, form masses and stimulate angiogenesis in zebrafsh. Angiogenesis 9, 139-151 (2006).
20. Eguiara, A. et al. Xenografts in zebrafsh embryos as a rapid functional assay for breast cancer stem-like cell identifcation. Cell Cycle 10, 3751-3757 (2011).
21. Westerfeld, M. The Zebrafsh Book: A Guide for the Laboratory Use of Zebrafsh (Danio rerio). University of Oregon Press, 4th edn. (2000).
22. Ellett, F., Pase, L., Hayman, J.W., Andrianopoulos, A. & Lieschke, G.J. mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafsh. Blood 117, e49-56 (2011).
23. Cosma, C.L., Swaim, L.E., Volkman, H., Ramakrishnan, L. & Davis, J.M. Zebrafsh and frog models of Mycobacterium marinum infection. Curr. Protoc. Microbiol. 3, 10B.2.1-10B.2.33 (2006).
24. Takaki, K., Cosma, C.L., Troll, M.A. & Ramakrishnan, L. An in vivo platform for rapid high-throughput antitubercular drug discovery. Cell Rep. 2, 175-184 (2012).
25. Tobin, D.M. et al. Host genotype-specifc therapies can optimize the infammatory response to mycobacterial infections. Cell 148, 434-446 (2012).
26. Adams, K.N. et al. Drug tolerance in replicating mycobacteria mediated by a macrophage-induced effux mechanism. Cell 145, 39-53 (2011).
27. Tobin, D.M. et al. The lta4h locus modulates susceptibility to mycobacterial infection in zebrafsh and humans. Cell 140, 717-730 (2010).
28. Clay, H., Volkman, H.E. & Ramakrishnan, L. Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Immunity 29, 283-294 (2008).
29. Wolinsky, E. Nontuberculous mycobacteria and associated diseases. Am. Rev. Respir. Dis. 119, 107-159 (1979).
30. Ramakrishnan, L. Images in clinical medicine. Mycobacterium marinum infection of the hand. N. Engl. J. Med. 337, 612 (1997).