메뉴 건너뛰기




Volumn 90, Issue 4, 2012, Pages 743-750

N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus

Author keywords

Hippocampus; Mercury; N acetyl cysteine; Neurogenesis; Programmed cell death

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; METHYLMERCURY;

EID: 84856726495     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22819     Document Type: Article
Times cited : (40)

References (30)
  • 1
    • 0033910788 scopus 로고    scopus 로고
    • Workshop to identify critical windows of exposure for children's health: neurobehavioral work group summary
    • Adams J, Barone S, LaMantia A, Philen R, Rice DC, Spear L, Susser E. 2000. Workshop to identify critical windows of exposure for children's health: neurobehavioral work group summary. Environ Health Perspect 108: 535-544.
    • (2000) Environ Health Perspect , vol.108 , pp. 535-544
    • Adams, J.1    Barone, S.2    LaMantia, A.3    Philen, R.4    Rice, D.C.5    Spear, L.6    Susser, E.7
  • 2
    • 0038165798 scopus 로고    scopus 로고
    • Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor
    • Aposhian HV, Morgan DL, Queen HL, Maiorino RM, Aposhian MM. 2003. Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor. J Toxicol Clin Toxicol 41: 339-347.
    • (2003) J Toxicol Clin Toxicol , vol.41 , pp. 339-347
    • Aposhian, H.V.1    Morgan, D.L.2    Queen, H.L.3    Maiorino, R.M.4    Aposhian, M.M.5
  • 3
    • 40949106884 scopus 로고    scopus 로고
    • N-acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure
    • Aremu DA, Madejczyk MS, Ballatori N. 2008. N-acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure. Environ Health Perspect 116: 26-31.
    • (2008) Environ Health Perspect , vol.116 , pp. 26-31
    • Aremu, D.A.1    Madejczyk, M.S.2    Ballatori, N.3
  • 4
    • 0031843490 scopus 로고    scopus 로고
    • N-acetylcysteine as an antidote in methylmercury poisoning
    • Ballatori N, Lieberman NW, Wang W. 1998. N-acetylcysteine as an antidote in methylmercury poisoning. Environm Health Perspect 106: 267-271.
    • (1998) Environm Health Perspect , vol.106 , pp. 267-271
    • Ballatori, N.1    Lieberman, N.W.2    Wang, W.3
  • 6
    • 33751508327 scopus 로고    scopus 로고
    • Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E
    • Burke K, Cheng Y, Li B, Petrov A, Joshi P, Berman RF, Reuhl KR, DiCicco-Bloom E. 2006. Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. Neurotoxicology 27: 970-981.
    • (2006) Neurotoxicology , vol.27 , pp. 970-981
    • Burke, K.1    Cheng, Y.2    Li, B.3    Petrov, A.4    Joshi, P.5    Berman, R.F.6    Reuhl, K.R.7    DiCicco-Bloom, E.8
  • 7
    • 23844550553 scopus 로고    scopus 로고
    • Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal
    • Burbacher TM, Shen DD, Liberato N, Grant KS, Cernichiari E, Clarkson T. 2005. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ Health Pespect 113: 1015-1021.
    • (2005) Environ Health Pespect , vol.113 , pp. 1015-1021
    • Burbacher, T.M.1    Shen, D.D.2    Liberato, N.3    Grant, K.S.4    Cernichiari, E.5    Clarkson, T.6
  • 8
    • 0036523039 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependant CDK2 activity
    • Carey RG, Li B, DiCicco-Bloom E. 2002. Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependant CDK2 activity. J Neurosci 22: 1583-1591.
    • (2002) J Neurosci , vol.22 , pp. 1583-1591
    • Carey, R.G.1    Li, B.2    DiCicco-Bloom, E.3
  • 9
    • 0017587329 scopus 로고
    • Degenerative changes in the developing nervous system as a result of in utero exposure to methylmercury
    • Chang LW, Reuhl KR, Lee GW. 1977. Degenerative changes in the developing nervous system as a result of in utero exposure to methylmercury. Environ Res 14: 414-423.
    • (1977) Environ Res , vol.14 , pp. 414-423
    • Chang, L.W.1    Reuhl, K.R.2    Lee, G.W.3
  • 10
    • 0036460609 scopus 로고    scopus 로고
    • Hippocampal granule neuron production and population size are regulated by levels of bFGF
    • Cheng Y, Black IB, DiCicco-Bloom E. 2002. Hippocampal granule neuron production and population size are regulated by levels of bFGF. Eur J Neurosci 15: 3-12.
    • (2002) Eur J Neurosci , vol.15 , pp. 3-12
    • Cheng, Y.1    Black, I.B.2    DiCicco-Bloom, E.3
  • 12
    • 0033534361 scopus 로고    scopus 로고
    • N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain
    • Dringen R, Hamprecht B. 1999. N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain. Neurosci Lett 259: 79-82.
    • (1999) Neurosci Lett , vol.259 , pp. 79-82
    • Dringen, R.1    Hamprecht, B.2
  • 13
    • 36248961154 scopus 로고    scopus 로고
    • Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty
    • Falluel-Morel A, Sokolowski K, Sisti HM, Zhou X, Shors TJ, Dicicco-Bloom E. 2007. Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty. J Neurochem 103: 1968-1981.
    • (2007) J Neurochem , vol.103 , pp. 1968-1981
    • Falluel-Morel, A.1    Sokolowski, K.2    Sisti, H.M.3    Zhou, X.4    Shors, T.J.5    Dicicco-Bloom, E.6
  • 14
    • 78649633268 scopus 로고    scopus 로고
    • Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species
    • Haase H, Engelhardt G, Hebel S, Rink L. 2011. Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species. Toxicol Appl Pharmacol 250: 78-86.
    • (2011) Toxicol Appl Pharmacol , vol.250 , pp. 78-86
    • Haase, H.1    Engelhardt, G.2    Hebel, S.3    Rink, L.4
  • 16
    • 33846249322 scopus 로고    scopus 로고
    • Role of glutathione in determining the differential sensitivity between the cortical and cerebellar regions towards mercury-induced oxidative stress
    • Kaur P, Aschner M, Syversen T. 2007. Role of glutathione in determining the differential sensitivity between the cortical and cerebellar regions towards mercury-induced oxidative stress. Toxicology 230: 164-177.
    • (2007) Toxicology , vol.230 , pp. 164-177
    • Kaur, P.1    Aschner, M.2    Syversen, T.3
  • 17
    • 0036784093 scopus 로고    scopus 로고
    • Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1
    • Koh AS, Simmons-Willis TA, Pritchard JB, Grassl SM, Ballatori N. 2002. Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1. Mol Pharmacol 62: 921-926.
    • (2002) Mol Pharmacol , vol.62 , pp. 921-926
    • Koh, A.S.1    Simmons-Willis, T.A.2    Pritchard, J.B.3    Grassl, S.M.4    Ballatori, N.5
  • 19
    • 0031004584 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide is an autocrine inhibitor of mitosis in cultured cortical precursor cells
    • Lu N, DiCicco-Bloom E. 1997. Pituitary adenylate cyclase-activating polypeptide is an autocrine inhibitor of mitosis in cultured cortical precursor cells. Proc Natl Acad Sci U S A 94: 3357-3362.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3357-3362
    • Lu, N.1    DiCicco-Bloom, E.2
  • 20
    • 34250693618 scopus 로고    scopus 로고
    • Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein
    • Madejczyk MS, Aremu DA, Simmons-Willis TA, Clarkson TW, Ballatori N. 2007. Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein. J Pharmacol and Exp Ther 322: 378-384.
    • (2007) J Pharmacol and Exp Ther , vol.322 , pp. 378-384
    • Madejczyk, M.S.1    Aremu, D.A.2    Simmons-Willis, T.A.3    Clarkson, T.W.4    Ballatori, N.5
  • 21
    • 1542358188 scopus 로고    scopus 로고
    • Gestational exposure to methylmercury retards choice in transition in aging rats
    • Newland MC, Reile PA, Langston JL. 2004. Gestational exposure to methylmercury retards choice in transition in aging rats. Neurotoxicol Teratol 26: 179-194.
    • (2004) Neurotoxicol Teratol , vol.26 , pp. 179-194
    • Newland, M.C.1    Reile, P.A.2    Langston, J.L.3
  • 23
    • 34247327455 scopus 로고    scopus 로고
    • The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury
    • Rooney JP. 2007. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 234: 145-156.
    • (2007) Toxicology , vol.234 , pp. 145-156
    • Rooney, J.P.1
  • 24
    • 0036710977 scopus 로고    scopus 로고
    • Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells
    • Shimizu E, Hashimoto K, Komatsu N, Iyo M. 2002. Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells. Neuropharmacology 43: 434-443.
    • (2002) Neuropharmacology , vol.43 , pp. 434-443
    • Shimizu, E.1    Hashimoto, K.2    Komatsu, N.3    Iyo, M.4
  • 25
    • 82455162364 scopus 로고    scopus 로고
    • Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures
    • Sokolowski K, Falluel-Morel A, Zhou X, DiCicco-Bloom E. 2011. Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures. Neurotoxicology (in press).
    • (2011) Neurotoxicology
    • Sokolowski, K.1    Falluel-Morel, A.2    Zhou, X.3    DiCicco-Bloom, E.4
  • 26
    • 32044450826 scopus 로고    scopus 로고
    • Prenatal methylmercury exposure and developmental outcomes: review of the evidence and discussion of future directions
    • Spurgeon A. 2006. Prenatal methylmercury exposure and developmental outcomes: review of the evidence and discussion of future directions. Environ Health Perspect 114: 307-312.
    • (2006) Environ Health Perspect , vol.114 , pp. 307-312
    • Spurgeon, A.1
  • 28
    • 0033565402 scopus 로고    scopus 로고
    • Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor
    • Wagner JP, Black IB, DiCicco-Bloom E. 1999. Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. J Neurosci 19: 6006-6016.
    • (1999) J Neurosci , vol.19 , pp. 6006-6016
    • Wagner, J.P.1    Black, I.B.2    DiCicco-Bloom, E.3
  • 29
    • 23944510034 scopus 로고    scopus 로고
    • Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1
    • Zalups RK, Ahmad S. 2005. Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1. J Pharmacol Exp Ther 314: 1158-1168.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1158-1168
    • Zalups, R.K.1    Ahmad, S.2
  • 30
    • 77957262510 scopus 로고    scopus 로고
    • Low molecular weight thiols reduce thimerosal neurotoxicity in vitro: modulation by proteins
    • Zieminska E, Toczylowska B, Stafiej A, Lazarewick JW. 2010. Low molecular weight thiols reduce thimerosal neurotoxicity in vitro: modulation by proteins. Toxicology 276: 154-163.
    • (2010) Toxicology , vol.276 , pp. 154-163
    • Zieminska, E.1    Toczylowska, B.2    Stafiej, A.3    Lazarewick, J.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.