The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells

Neurochemical Research

Volumn 34, Issue 9, 2009, Pages 1677-1684

  Becker, Alan ^a   Soliman, Karam F A ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

Cystine; GSH; GSSG; N acetylcysteine; Synthesis

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; MERCURY CHLORIDE; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; ATTENUATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; GLUTATHIONE METABOLISM; INTRACELLULAR SPACE; MOUSE; NEURITE; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ACETYLCYSTEINE; ANIMALS; BUTHIONINE SULFOXIMINE; CELL LINE, TUMOR; CELL SURVIVAL; CYTOPROTECTION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; MERCURIC CHLORIDE; MERCURY POISONING; MICE; NEUROBLASTOMA; SULFHYDRYL COMPOUNDS;

EID: 68349144135     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-9962-3     Document Type: Article

References (36)

1. ME Anderson 1998 Glutathione: an overview of biosynthesis and modulation Chem Biol Interact 11-112 1 14
2. ME Anderson A Meister 1989 Glutathione monoesters J Anal Biochem 183 16 20
3. JK Andersen JQ Mo KG Hom FY Lee P Harnish RW Hamill TH McNeill 1996 Effect of buthionine sulfoximine, a synthesis inhibitor of the antioxidant glutathione, on the murine nigrostriatal neurons J Neurochem 67 2164 2171
4. HV Aposhian 1983 DMSA and DMPS-water soluble antidotes for heavy metal poisoning Annu Rev Pharmacol Toxicol 23 193 215
5. HV Aposhian MM Aposhian 1990 Meso-2, 3-dimercaptosuccinic acid: chemical pharmacological and toxicological properties of an orally effective metal chelating agent Annu Rev Pharmacol Toxicol 30 279 306
6. HV Aposhian RM Maiorino M Rivera 1992 Human studies with the chelating agents. DMPS and DMSA Clin Toxicol 30 505 528
7. M Aschner KS Mullaney D Wagoner LH Lash HK Kimelberg 1994 Intracellular glutathione (GSH) levels modulate mercuric chloride and methylmercuric chloride induced amino acid release from neonatal rat primary astrocyte cultures Brain Res 644 133 140
8. Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (2001) Harrison's Principles of Internal Medicine, McGraw-Hill, New York, pp. 467-469, 2592-2593, 2602
9. MA Baker GJ Cerniglia A Zaman 1990 Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples Anal Biochem 190 360 365
10. LA Chapman HM Chan 1999 Inorganic mercury pre-exposures protect against methyl mercury toxicity in NSC-34 (neuron × spinal cord hybrid cells Toxicology 132 167 178
11. RM Clancy D Levartovsky J Leszcynska-Piziak J Yegudin SB Abramson 1994 Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediate Proc Natl Acad Sci USA 91 3680 3684
12. TW Clarkson 1992 Mercury: major issues in environmental health Environ Health Perspect 100 31 38
13. Cooper AJL (1998) Role of astrocytes in maintaining cerebral glutathione homeostasis and in protecting the brain against xenobiotics and oxidative stress. In: Shaw CA (ed) The role of glutathione in the nervous system. Taylor and Francis, Washington, pp 91-115
14. L Cotgreave 1997 N-Acetylcysteine: pharmacological considerations and experimental and clinical applications Adv Pharmacol 38 205 227
15. WD Ehmann WR Markesbery M Alauddin TIM Hossain EH Brubaker 1986 Brain trace elements in alzheimer's disease Neurotoxicology 7 197 206
16. SM Evans A Casartell E Herreros DT Minnick 2001 Development of a high throughput in vitro toxicity screen predictive of high acute in vivo toxic potential Toxicol In Vitro 15 579 584
17. OW Griffith 1980 Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine Anal Biochem 106 207 212
18. S Hussain DA Rodgers HM Duhart SF Ali 1997 Mercuric chloride-induced reactive oxygen species and its effect on antioxidant enzymes in different regions of rat brain J Environ Sci Health B 32 395 409
19. LH Lash RK Zalups 1992 Mercuric chloride-induced cytotoxicology and compensatory hypertrophy in rat kidney proximal tubular cells J Pharmacol Exp Ther 261 819 829
20. LH Lash RK Zalups 1996 Alterations in renal cellular glutathione metabolism after in vivo administration of a subtoxic dose of mercuric chloride J Biochem Toxicol 11 1 9
21. E Mazzio KFA Soliman 2003 D- (+)-Glucose rescue against 1-methyl-4-phenylpyridinium toxicity through anaerobic glycolysis in neuroblastoma cells Brain Res 962 48 60
22. E Mazzio KJ Yoon KF Soliman 2003 Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells Biochem Pharmacol 66 297 306 (Pubitemid 36776403)
23. RL Messer PE Lockwood WY Tseng K Edwards M Shaw GB Caughman JB Lewis JC Wataha 2005 Mercury (II) alters mitochondrial activity of monocytes at sublethal doses via oxidative stress mechanisms J Biomed Mater Res B Appl Biomater 75 257 263
24. T Mizui H Kinouchi PH Chan 1992 Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats Am J Physiol 262 H313 H317
25. J Mutter J Naumann C Sadaghiani H Walach G Drasch 2004 Amalgam studies: disregarding basic principles of mercury toxicity Int J Hyg Environ Health 207 391 397
26. A Naganuma ME Anderson A Meister 1990 Cellular glutathione as a determinant of sensitivity to mercuric chloride toxicity Biochem Pharmacol 40 693 697
27. G Olivieri C Brack F Müller-Spahn HB Stähelin M Herrmann P Renard M Brockhaus C Hock 2000 Mercury induces cell cytotoxicity and oxidative stress and increases b-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells J Neurochem 74 231 236
28. JPK Rooney 2007 The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury Toxicology 234 145 156
29. Saez GT, Bannister WH, Bannister JV (1990) Free radicals and thiol compounds-the role of glutathione against free radical toxicity. In: Vivo J (ed) Glutathione: metabolism and physiological functions. CRC Press, Boca Raton, pp 237-254
30. ME Vahter MK Mottet LT Enberg SB Lind JS Charleston TM Burbacker 1995 Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure Toxicol Appl Pharmacol 134 273 284
31. CC Winterbourn D Metodiewa 1994 The reactions of superoxide with reduced glutathione Arch Biochem Biophys 314 284 290
32. JM Williamson B Boettcher A Meister 1982 Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis Proc Natl Acad Sci 79 6246 6249
33. X Wu H Liang KA O'Hara JC Yalowich BB Hasinoff 2008 Thiol-modulated mechanism of the cytotoxity of thimerosal and inhibition of DNA topoisomerase II alpha Chem Res Toxicol 21 483 493
34. RK Zalups 2000 Molecular interactions with mercury in the kidney Pharmacol Rev 52 113 143
35. RK Zalups LH Lash 1994 Advances in understanding the renal transport and toxicity of mercury J Toxicol Environ Health 42 1 44
36. DM Ziegler 1985 Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation Annu Rev Biochem 54 305 330