Detoxification of mercury species-an in vitro study with antidotes in human whole blood

Analytical and Bioanalytical Chemistry

Volumn 395, Issue 6, 2009, Pages 1929-1935

  Trümpler, Stefan ^a   Nowak, Sascha ^a   Meermann, Björn ^a   Wiesmüller, Gerhard A ^b   Buscher, Wolfgang ^a   Sperling, Michael ^a   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Antidotes; Human whole blood; Intoxication; Mercury; Methylmercury; Speciation analysis

Indexed keywords

ANTIDOTES; HUMAN WHOLE BLOOD; INTOXICATION; MERCURY; METHYLMERCURY; SPECIATION ANALYSIS;

BLOOD; CHROMATOGRAPHIC ANALYSIS; DETOXIFICATION; ELECTROSPRAY IONIZATION; INDUCTIVELY COUPLED PLASMA; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MERCURY COMPOUNDS; SPECTROMETRY; SULFUR COMPOUNDS;

MERCURY (METAL);

ANTIDOTE; MERCURY; METHYLMERCURY DERIVATIVE;

ADULT; ARTICLE; BIOLOGICAL MODEL; BLOOD; CHEMISTRY; DRUG DETOXIFICATION; EVALUATION; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METHODOLOGY;

ADULT; ANTIDOTES; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; MERCURY; METABOLIC DETOXICATION, DRUG; METHYLMERCURY COMPOUNDS; MODELS, BIOLOGICAL;

EID: 70449559111     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-009-3105-1     Document Type: Article

References (21)

1. Horvat M, Gibicar D (2005) In: Cornelis R (ed) Handbook of elemental speciation II. Wiley, Weinheim, pp 281-304
2. CC Bridges RK Zalups 2005 Molecular and ionic mimicry and the transport of toxic metals Toxicol Appl Pharmacol 204 274 308 10.1016/j.taap.2004.09.007 1:CAS:528:DC%2BD2MXjsFGqt7w%3D (Pubitemid 40545232)
3. TW Clarkson L Magos 2006 The toxicology of mercury and its chemical compounds Crit Rev Toxicol 36 609 662 10.1080/10408440600845619 1:CAS:528:DC%2BD28XhtFGht73L (Pubitemid 44396731)
4. KJ Oh K Park TW Kang DD Kwon SB Ryu 2007 Subcutaneous metallic mercury injection for penile augmentation Urology 69 185e3 185e4 10.1016/j.urology.2006. 10.028 (Pubitemid 46161714)
5. BM Varnai PM VM K Kostial 2005 Chelators as antidotes of metal toxicity: therapeutic and experimental aspects Curr Med Chem 12 2771 2794 10.2174/092986705774462987 (Pubitemid 41601574)
6. O Andersen J Aaseth 2002 Molecular mechanisms of in vivo metal chelation: implications for clinical treatment of metal intoxications Environ Health Perspect 110 Suppl. 5 887 890 1:CAS:528:DC%2BD38XovFKhtLc%3D
7. International Programme on Chemical Safety (IPCS) INCHEM. Dimercaprol, Canadian Centre for Occupational Health and Safety and International Programme on Chemical Safety, 1990. ( http://www.inchem.org/documents/pims/pharm/dimercap. htm )
8. A de la Torre M Bellés JM Llobet E Mayayo JL Domingo 1998 Comparison of the effectiveness of 2, 3-dimercaptopropanol (BAL) and meso-2, 3-dimercaptosuccinic Acid (DMSA) as protective agents against mercury chloride-induced nephrotoxicity in rats Biol Trace Elem Res 63 1 10 10.1007/BF02785272
9. GN George RC Prince J Gailer GA Buttigieg MB Denton HH Harris IJ Pickering 2004 Mercury binding to the chelation therapy agents DMSA and DMPS and the rational design of custom chelators for mercury Chem Res Toxicol 17 999 1006 10.1021/tx049904e 1:CAS:528:DC%2BD2cXlvVaqtrk%3D (Pubitemid 39108670)
10. N Ballatori MW Lieberman W Wang 1998 N-Acetlycysteine as an antidote for mercury poisoning Environ Health Perspect 106 267 271 10.2307/3434014 1:CAS:528:DyaK1cXjslGnsrs%3D
11. R Brandão FW Santos G Zeni JBT Rocha CW Nogueira 2006 DMPS and N-acetylcysteine induced renal toxicity in mice exposed to mercury BioMetals 19 389 398 10.1007/s10534-005-4020-3 (Pubitemid 44066276)
12. DA Aremu MS Madejczyk N Ballatori 2008 N-Acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure Environ Health Perspect 116 26 31 1:CAS:528:DC%2BD1cXhs12gu7Y%3D
13. O Andersen 2004 Chemical and biological considerations in the treatment of metal intoxications by chelating agents Mini-Rev Med Chem 4 11 21 10.2174/1389557043487583 1:CAS:528:DC%2BD2cXhtVagtrk%3D (Pubitemid 38849366)
14. MS Madejczyk DA Aremu TA Simmons-Willis TW Clarkson N Ballatori 2007 Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein J Pharmacol Exp Ther 322 378 384 10.1124/jpet.107.122812 1:CAS:528:DC%2BD2sXntl2jtbg%3D (Pubitemid 46956364)
15. DC Baxter I Rodushkin E Engström D Klockare H Waara 2007 Methylmercury measurement in whole blood by isotope-dilution GC-ICPMS with 2 sample preparation methods Clin Chem 53 111 116 10.1373/clinchem.2007.072520 1:CAS:528:DC%2BD2sXmsFGitQ%3D%3D (Pubitemid 46047770)
16. EM Krupp BF Milne A Mestrot AA Meharg J Feldmann 2008 Investigation into mercury bound to biothiols: structural identification using ESI-Ion-Trap MS and introduction of a method for their HPLC separation with simultaneous detection by ICP-MS and ESI-MS Anal Bioanal Chem 390 1753 1764 10.1007/s00216-008-1927-x 1:CAS:528:DC%2BD1cXjsFWrsL4%3D
17. Y Li X-P Yan C Chen Y-L Xia Y Jiang 2007 Human serum albumin-mercurial species interactions J Proteom Res 6 2277 2286 10.1021/pr0700403 1:CAS:528:DC%2BD2sXltVKqtbo%3D (Pubitemid 46985115)
18. Trümpler S, Meermann B, Nowak S, Wiesmüller GA, Buscher W, Karst U, Sperling M (2009) In vitro study of thimerosal reactions with human whole blood, submitted for publication
19. S Trümpler W Lohmann B Meermann W Buscher M Sperling U Karst 2009 Interaction of thimerosal with proteins-ethylmercury adduct formation of human serum albumin and β-lactoglobulin A Metallomics 1 87 91 10.1039/b815978e
20. CA Lang AP Matheny Jr W Mastropaolo MC Liu 2001 Blood glutathione and cysteine concentrations in twin children Exp Bio Med 226 349 352 1:CAS:528:DC%2BD3MXjtlGgsb0%3D
21. 2 Basic Clin Pharmacol Toxicol 96 302 308 10.1111/j.1742-7843. 2005.pto960405.x 1:CAS:528:DC%2BD2MXivFCrs7o%3D (Pubitemid 40432478)