메뉴 건너뛰기




Volumn 137, Issue 9, 2015, Pages 2072-2082

Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer

Author keywords

cisplatin resistance; DNA damage repair; lung cancer; MARK2; NF B

Indexed keywords

CISPLATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAX PROTEIN; MICROTUBULE AFFINITY REGULATING KINASE 2; MYC PROTEIN; PROTEIN KINASE; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MARK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

EID: 84939588821     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29577     Document Type: Article
Times cited : (36)

References (36)
  • 3
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Consortia TCGA
    • Consortia TCGA. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012; 489: 519-25.
    • (2012) Nature , vol.489 , pp. 519-525
  • 4
    • 84905029258 scopus 로고    scopus 로고
    • Comprehensive molecular profiling of lung adenocarcinoma
    • Consortia TCGA
    • Consortia TCGA. Comprehensive molecular profiling of lung adenocarcinoma. Nature 2014; 511: 543-50.
    • (2014) Nature , vol.511 , pp. 543-550
  • 5
    • 84887015191 scopus 로고    scopus 로고
    • Genetic alterations defining NSCLC subtypes and their therapeutic implications
    • Pikor LA, Ramnarine VR, Lam S, Lam WL,. Genetic alterations defining NSCLC subtypes and their therapeutic implications. Lung Cancer 2013; 82: 179-89.
    • (2013) Lung Cancer , vol.82 , pp. 179-189
    • Pikor, L.A.1    Ramnarine, V.R.2    Lam, S.3    Lam, W.L.4
  • 6
    • 0030969575 scopus 로고    scopus 로고
    • MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
    • Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E,. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 1997; 89: 297-308.
    • (1997) Cell , vol.89 , pp. 297-308
    • Drewes, G.1    Ebneth, A.2    Preuss, U.3    Mandelkow, E.M.4    Mandelkow, E.5
  • 7
    • 67649983118 scopus 로고    scopus 로고
    • The tau of MARK: A polarized view of the cytoskeleton
    • Matenia D, Mandelkow EM,. The tau of MARK: a polarized view of the cytoskeleton. Trend Biochem Sci 2009; 34: 332-42.
    • (2009) Trend Biochem Sci , vol.34 , pp. 332-342
    • Matenia, D.1    Mandelkow, E.M.2
  • 8
    • 0035097790 scopus 로고    scopus 로고
    • Isolation of a novel human gene, markl1, homologous to mark3 and its involvement in hepatocellular carcinogenesis
    • Kato T, Satoh S, Okabe H, et al., Isolation of a novel human gene, markl1, homologous to mark3 and its involvement in hepatocellular carcinogenesis. Neoplasia 2001; 3: 4-9.
    • (2001) Neoplasia , vol.3 , pp. 4-9
    • Kato, T.1    Satoh, S.2    Okabe, H.3
  • 9
    • 77952672714 scopus 로고    scopus 로고
    • Identification and functional analysis of genes which confer resistance to cisplatin in tumor cells
    • Wu ZZ, Lu HP, Chao CC,. Identification and functional analysis of genes which confer resistance to cisplatin in tumor cells. Biochem Pharmacol 2010; 80: 262-76.
    • (2010) Biochem Pharmacol , vol.80 , pp. 262-276
    • Wu, Z.Z.1    Lu, H.P.2    Chao, C.C.3
  • 10
    • 40349089783 scopus 로고    scopus 로고
    • Multiple end-point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: Implications for predictive testing
    • Almeida GM, Duarte TL, Farmer PB, et al., Multiple end-point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: implications for predictive testing. Int J Cancer 2008; 122: 1810-9.
    • (2008) Int J Cancer , vol.122 , pp. 1810-1819
    • Almeida, G.M.1    Duarte, T.L.2    Farmer, P.B.3
  • 11
    • 84891472568 scopus 로고    scopus 로고
    • In Vitro analysis of the relationships between metallothionein expression and cisplatin sensitivity of Non-small cellular lung cancer cells
    • Gansukh T, Donizy P, Halon A, et al., In Vitro analysis of the relationships between metallothionein expression and cisplatin sensitivity of Non-small cellular lung cancer cells. Anticancer Res 2013; 33: 5255-60.
    • (2013) Anticancer Res , vol.33 , pp. 5255-5260
    • Gansukh, T.1    Donizy, P.2    Halon, A.3
  • 12
    • 0034688940 scopus 로고    scopus 로고
    • DNA-adduct levels as a predictor of outcome for NSCLC patients receiving daily cisplatin and radiotherapy
    • van de Vaart PJ, Belderbos J, de Jong D, et al., DNA-adduct levels as a predictor of outcome for NSCLC patients receiving daily cisplatin and radiotherapy. Int J Cancer 2000; 89: 160-6.
    • (2000) Int J Cancer , vol.89 , pp. 160-166
    • Van De Vaart, P.J.1    Belderbos, J.2    De Jong, D.3
  • 13
    • 84863273943 scopus 로고    scopus 로고
    • Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability
    • Thu KL, Vucic EA, Chari R, et al., Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability. PloS One 2012; 7: e33003
    • (2012) PloS One , vol.7 , pp. e33003
    • Thu, K.L.1    Vucic, E.A.2    Chari, R.3
  • 14
    • 84884967805 scopus 로고    scopus 로고
    • Eya4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk
    • Wilson IM, Vucic EA, Enfield KS, et al., Eya4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene 2014; 33: 4464-73.
    • (2014) Oncogene , vol.33 , pp. 4464-4473
    • Wilson, I.M.1    Vucic, E.A.2    Enfield, K.S.3
  • 15
    • 84876563391 scopus 로고    scopus 로고
    • Genomics of drug sensitivity in cancer (GDSC): A resource for therapeutic biomarker discovery in cancer cells
    • Yang W, Soares J, Greninger P, et al., Genomics of drug sensitivity in cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res 2013; 41: D955-61.
    • (2013) Nucleic Acids Res , vol.41 , pp. D955-D961
    • Yang, W.1    Soares, J.2    Greninger, P.3
  • 16
    • 10844284696 scopus 로고    scopus 로고
    • Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    • Ramirez RD, Sheridan S, Girard L, et al., Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res 2004; 64: 9027-34.
    • (2004) Cancer Res , vol.64 , pp. 9027-9034
    • Ramirez, R.D.1    Sheridan, S.2    Girard, L.3
  • 17
    • 32044443405 scopus 로고    scopus 로고
    • Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1
    • Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E,. Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure. 2006; 14: 173-83.
    • (2006) Structure , vol.14 , pp. 173-183
    • Panneerselvam, S.1    Marx, A.2    Mandelkow, E.M.3    Mandelkow, E.4
  • 18
    • 84880893647 scopus 로고    scopus 로고
    • Ezh2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation
    • Hubaux R, Thu KL, Coe BP, et al., Ezh2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation. J Thoracic Oncol 2013; 8: 1102-6.
    • (2013) J Thoracic Oncol , vol.8 , pp. 1102-1106
    • Hubaux, R.1    Thu, K.L.2    Coe, B.P.3
  • 19
    • 80052268120 scopus 로고    scopus 로고
    • Genetic disruption of keap1/cul3 e3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer
    • 1521
    • Thu KL, Pikor LA, Chari R, et al., Genetic disruption of keap1/cul3 e3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer. J Thoracic Oncol 2011; 6: 1521
    • (2011) J Thoracic Oncol , vol.6
    • Thu, K.L.1    Pikor, L.A.2    Chari, R.3
  • 20
    • 77955034636 scopus 로고    scopus 로고
    • Integrative genomic analyses identify brf2 as a novel lineage-specific oncogene in lung squamous cell carcinoma
    • Lockwood WW, Chari R, Coe BP, et al., Integrative genomic analyses identify brf2 as a novel lineage-specific oncogene in lung squamous cell carcinoma. PLoS Med 2010; 7: e1000315
    • (2010) PLoS Med , vol.7 , pp. e1000315
    • Lockwood, W.W.1    Chari, R.2    Coe, B.P.3
  • 21
    • 84891277461 scopus 로고    scopus 로고
    • Yeats4 is a novel oncogene amplified in Non-small cell lung cancer that regulates the p53 pathway
    • Pikor LA, Lockwood WW, Thu KL, et al., Yeats4 is a novel oncogene amplified in Non-small cell lung cancer that regulates the p53 pathway. Cancer Res 2013; 73: 7301-12.
    • (2013) Cancer Res , vol.73 , pp. 7301-7312
    • Pikor, L.A.1    Lockwood, W.W.2    Thu, K.L.3
  • 22
    • 1942534150 scopus 로고    scopus 로고
    • Assessment of histone H2AX phosphorylation induced by DNA topoisomerase i and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin
    • Huang X, Okafuji M, Traganos F, et al., Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin. Cytometry Part A 2004; 58: 99-110.
    • (2004) Cytometry Part A , vol.58 , pp. 99-110
    • Huang, X.1    Okafuji, M.2    Traganos, F.3
  • 23
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, et al., Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005; 102: 15545-50.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3
  • 24
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G,. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001; 98: 5116-21.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 25
    • 82355171931 scopus 로고    scopus 로고
    • Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: Inhibitors with therapeutic potential
    • Timm T, von Kries JP, Li X, et al., Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential. J Biol Chem 2011; 286: 41711-22.
    • (2011) J Biol Chem , vol.286 , pp. 41711-41722
    • Timm, T.1    Von Kries, J.P.2    Li, X.3
  • 26
    • 33646006734 scopus 로고    scopus 로고
    • Signals from within: The DNA-damage-induced NF-kappaB response
    • Janssens S, Tschopp J,. Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Diff 2006; 13: 773-84.
    • (2006) Cell Death Diff , vol.13 , pp. 773-784
    • Janssens, S.1    Tschopp, J.2
  • 27
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, et al., DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273: 5858-68.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3
  • 28
    • 84866042698 scopus 로고    scopus 로고
    • GammaH2AX as a novel endpoint to detect DNA damage: Applications for the assessment of the in vitro genotoxicity of cigarette smoke
    • Garcia-Canton C, Anadon A, Meredith C,. gammaH2AX as a novel endpoint to detect DNA damage: applications for the assessment of the in vitro genotoxicity of cigarette smoke. Toxicol In Vitro 2012; 26: 1075-86.
    • (2012) Toxicol in Vitro , vol.26 , pp. 1075-1086
    • Garcia-Canton, C.1    Anadon, A.2    Meredith, C.3
  • 29
    • 48749122628 scopus 로고    scopus 로고
    • Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3
    • Traweger A, Wiggin G, Taylor L, et al., Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3. Proc Natl Acad Sci U S A 2008; 105: 10402-7.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10402-10407
    • Traweger, A.1    Wiggin, G.2    Taylor, L.3
  • 30
    • 45949103263 scopus 로고    scopus 로고
    • Accurate balance of the polarity kinase mark2/Par-1 is required for proper cortical neuronal migration
    • Sapir T, Sapoznik S, Levy T, et al., Accurate balance of the polarity kinase mark2/Par-1 is required for proper cortical neuronal migration. J Neurosci 2008; 28: 5710-20.
    • (2008) J Neurosci , vol.28 , pp. 5710-5720
    • Sapir, T.1    Sapoznik, S.2    Levy, T.3
  • 31
    • 0034943604 scopus 로고    scopus 로고
    • PAR-1 is a Dishevelled-associated kinase and a positive regulator of wnt signalling
    • Sun TQ, Lu B, Feng JJ, et al., PAR-1 is a Dishevelled-associated kinase and a positive regulator of wnt signalling. Nat Cell Biol 2001; 3: 628-36.
    • (2001) Nat Cell Biol , vol.3 , pp. 628-636
    • Sun, T.Q.1    Lu, B.2    Feng, J.J.3
  • 32
    • 84866107779 scopus 로고    scopus 로고
    • Signaling crosstalk between TGFbeta and dishevelled/Par1b
    • Mamidi A, Inui M, Manfrin A, et al., Signaling crosstalk between TGFbeta and dishevelled/Par1b. Cell Death Diff 2012; 19: 1689-97.
    • (2012) Cell Death Diff , vol.19 , pp. 1689-1697
    • Mamidi, A.1    Inui, M.2    Manfrin, A.3
  • 33
    • 19944372081 scopus 로고    scopus 로고
    • Distinct PAR-1 proteins function in different branches of wnt signaling during vertebrate development
    • Ossipova O, Dhawan S, Sokol S, Green JB,. Distinct PAR-1 proteins function in different branches of wnt signaling during vertebrate development. Dev Cell 2005; 8: 829-41.
    • (2005) Dev Cell , vol.8 , pp. 829-841
    • Ossipova, O.1    Dhawan, S.2    Sokol, S.3    Green, J.B.4
  • 34
    • 84901797205 scopus 로고    scopus 로고
    • PAR-4/lkb1 regulates DNA replication during asynchronous division of the early C. Elegans embryo
    • Benkemoun L, Descoteaux C, Chartier NT, et al., PAR-4/lkb1 regulates DNA replication during asynchronous division of the early C. Elegans embryo. J Cell Biol 2014; 205: 447-55.
    • (2014) J Cell Biol , vol.205 , pp. 447-455
    • Benkemoun, L.1    Descoteaux, C.2    Chartier, N.T.3
  • 35
    • 0442323562 scopus 로고    scopus 로고
    • NF-kappaB: Tumor promoter or suppressor?
    • Perkins ND,. NF-kappaB: tumor promoter or suppressor? Trend Cell Biol 2004; 14: 64-9.
    • (2004) Trend Cell Biol , vol.14 , pp. 64-69
    • Perkins, N.D.1
  • 36
    • 33746829168 scopus 로고    scopus 로고
    • Pro-apoptotic role of NF-kappaB: Implications for cancer therapy
    • Radhakrishnan SK, Kamalakaran S,. Pro-apoptotic role of NF-kappaB: implications for cancer therapy. Biochim Biophys Acta 2006; 1766: 53-62.
    • (2006) Biochim Biophys Acta , vol.1766 , pp. 53-62
    • Radhakrishnan, S.K.1    Kamalakaran, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.