Reduced protein turnover mediates functional deficits in transgenic mice expressing the 25 kDa C-terminal fragment of TDP-43

Human Molecular Genetics

Volumn 24, Issue 16, 2015, Pages 4625-4635

  Caccamo, Antonella ^a,b   Shaw, Darren M ^a   Guarino, Francesca ^b   Messina, Angela ^b   Walker, Aaron W ^a   Oddo, Salvatore ^a,c  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 27; PROTEASOME; TAR DNA BINDING PROTEIN; DNA BINDING PROTEIN; TDP-43 PROTEIN, HUMAN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; COGNITION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; FRONTOTEMPORAL DEMENTIA; GENE DOSAGE; GENOTYPE; HOMOZYGOTE; MILD COGNITIVE IMPAIRMENT; MORRIS WATER MAZE TEST; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; RADIAL ARM MAZE TEST; ROTAROD TEST; SPATIAL MEMORY; STEADY STATE; TDP 43 PROTEINOPATHY; WESTERN BLOTTING; WORKING MEMORY; ANIMAL; ANIMAL BEHAVIOR; GENETICS; HUMAN; METABOLISM; PROTEIN DEGRADATION; PROTEIN TERTIARY STRUCTURE; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AUTOPHAGY; BEHAVIOR, ANIMAL; DNA-BINDING PROTEINS; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; MICE; MICE, TRANSGENIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 84939533463     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv193     Document Type: Article

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