-
1
-
-
84155167265
-
Gains or losses: Molecular mechanisms of TDP43-mediated neurodegeneration
-
Lee, E. B., Lee, V. M., and Trojanowski, J. Q. (2012) Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nat. Rev. Neurosci. 13, 38-50
-
(2012)
Nat. Rev. Neurosci.
, vol.13
, pp. 38-50
-
-
Lee, E.B.1
Lee, V.M.2
Trojanowski, J.Q.3
-
2
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
DOI 10.1126/science.1134108
-
Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., McCluskey, L. F., Miller, B. L., Masliah, E., Mackenzie, I. R., Feldman, H., Feiden, W., Kretzschmar, H. A., Trojanowski, J. Q., and Lee, V. M. (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130-133 (Pubitemid 44547757)
-
(2006)
Science
, vol.314
, Issue.5796
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.K.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
Bruce, J.7
Schuck, T.8
Grossman, M.9
Clark, C.M.10
McCluskey, L.F.11
Miller, B.L.12
Masliah, E.13
Mackenzie, I.R.14
Feldman, H.15
Feiden, W.16
Kretzschmar, H.A.17
Trojanowski, J.Q.18
Lee, V.M.-Y.19
-
3
-
-
34249949338
-
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
-
DOI 10.1002/ana.21154
-
Amador-Ortiz, C., Lin, W. L., Ahmed, Z., Personett, D., Davies, P., Duara, R., Graff-Radford, N. R., Hutton, M. L., and Dickson, D. W. (2007) TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. Ann. Neurol. 61, 435-445 (Pubitemid 46878771)
-
(2007)
Annals of Neurology
, vol.61
, Issue.5
, pp. 435-445
-
-
Amador-Ortiz, C.1
Lin, W.-L.2
Ahmed, Z.3
Personett, D.4
Davies, P.5
Duara, R.6
Graff-Radford, N.R.7
Hutton, M.L.8
Dickson, D.W.9
-
4
-
-
41149180753
-
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
-
DOI 10.1126/science.1154584
-
Sreedharan, J., Blair, I. P., Tripathi, V. B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J. C., Williams, K. L., Buratti, E., Baralle, F., de Belleroche, J., Mitchell, J. D., Leigh, P. N., Al-Chalabi, A., Miller, C. C., Nicholson, G., and Shaw, C. E. (2008) TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 319, 1668-1672 (Pubitemid 351432505)
-
(2008)
Science
, vol.319
, Issue.5870
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
Rogelj, B.6
Ackerley, S.7
Durnall, J.C.8
Williams, K.L.9
Buratti, E.10
Baralle, F.11
De Belleroche, J.12
Mitchell, J.D.13
Leigh, P.N.14
Al-Chalabi, A.15
Miller, C.C.16
Nicholson, G.17
Shaw, C.E.18
-
5
-
-
52949094629
-
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis
-
Rutherford, N. J., Zhang, Y. J., Baker, M., Gass, J. M., Finch, N. A., Xu, Y. F., Stewart, H., Kelley, B. J., Kuntz, K., Crook, R. J., Sreedharan, J., Vance, C., Sorenson, E., Lippa, C., Bigio, E. H., Geschwind, D. H., Knopman, D. S., Mitsumoto, H., Petersen, R. C., Cashman, N. R., Hutton, M., Shaw, C. E., Boylan, K. B., Boeve, B., Graff-Radford, N. R., Wszolek, Z. K., Caselli, R. J., Dickson, D. W., Mackenzie, I. R., Petrucelli, L., and Rademakers, R. (2008) Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. PLoS Genet. 4, e1000193
-
(2008)
PLoS Genet.
, vol.4
-
-
Rutherford, N.J.1
Zhang, Y.J.2
Baker, M.3
Gass, J.M.4
Finch, N.A.5
Xu, Y.F.6
Stewart, H.7
Kelley, B.J.8
Kuntz, K.9
Crook, R.J.10
Sreedharan, J.11
Vance, C.12
Sorenson, E.13
Lippa, C.14
Bigio, E.H.15
Geschwind, D.H.16
Knopman, D.S.17
Mitsumoto, H.18
Petersen, R.C.19
Cashman, N.R.20
Hutton, M.21
Shaw, C.E.22
Boylan, K.B.23
Boeve, B.24
Graff-Radford, N.R.25
Wszolek, Z.K.26
Caselli, R.J.27
Dickson, D.W.28
Mackenzie, I.R.29
Petrucelli, L.30
Rademakers, R.31
more..
-
6
-
-
0035794665
-
Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping
-
DOI 10.1093/emboj/20.7.1774
-
Buratti, E., Dörk, T., Zuccato, E., Pagani, F., Romano, M., and Baralle, F. E. (2001) Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. EMBO J. 20, 1774-1784 (Pubitemid 32299413)
-
(2001)
EMBO Journal
, vol.20
, Issue.7
, pp. 1774-1784
-
-
Buratti, E.1
Dork, T.2
Zuccato, E.3
Pagani, F.4
Romano, M.5
Baralle, F.E.6
-
7
-
-
34848921202
-
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
-
DOI 10.1523/JNEUROSCI.3421-07.2007
-
Zhang, Y. J., Xu, Y. F., Dickey, C. A., Buratti, E., Baralle, F., Bailey, R., Pickering-Brown, S., Dickson, D., and Petrucelli, L. (2007) Progranulin mediates caspase-dependent cleavage of TAR DNA-binding protein-43. J. Neurosci. 27, 10530-10534 (Pubitemid 47501990)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.39
, pp. 10530-10534
-
-
Zhang, Y.-J.1
Xu, Y.-F.2
Dickey, C.A.3
Buratti, E.4
Baralle, F.5
Bailey, R.6
Pickering-Brown, S.7
Dickson, D.8
Petrucelli, L.9
-
8
-
-
44749091997
-
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation
-
Winton, M. J., Igaz, L. M., Wong, M. M., Kwong, L. K., Trojanowski, J. Q., and Lee, V. M. (2008) Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J. Biol. Chem. 283, 13302-13309
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 13302-13309
-
-
Winton, M.J.1
Igaz, L.M.2
Wong, M.M.3
Kwong, L.K.4
Trojanowski, J.Q.5
Lee, V.M.6
-
9
-
-
49349104833
-
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease
-
Rohn, T. T. (2008) Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease. Brain Res. 1228, 189-198
-
(2008)
Brain Res.
, vol.1228
, pp. 189-198
-
-
Rohn, T.T.1
-
10
-
-
80755153025
-
TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies
-
Cohen, T. J., Lee, V. M., and Trojanowski, J. Q. (2011) TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies. Trends Mol. Med. 17, 659-667
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 659-667
-
-
Cohen, T.J.1
Lee, V.M.2
Trojanowski, J.Q.3
-
11
-
-
85040709233
-
Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments
-
Zhang, Y. J., Gendron, T. F., Xu, Y. F., Ko, L. W., Yen, S. H., and Petrucelli, L. (2010) Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments. Mol. Neurodegener. 5, 33
-
(2010)
Mol. Neurodegener.
, vol.5
, pp. 33
-
-
Zhang, Y.J.1
Gendron, T.F.2
Xu, Y.F.3
Ko, L.W.4
Yen, S.H.5
Petrucelli, L.6
-
12
-
-
59449107850
-
Targeting CDC37: An alternative, kinase-directed strategy for disruption of oncogenic chaperoning
-
Smith, J. R., and Workman, P. (2009) Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning. Cell Cycle 8, 362-372
-
(2009)
Cell Cycle
, vol.8
, pp. 362-372
-
-
Smith, J.R.1
Workman, P.2
-
13
-
-
0034329452
-
Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23
-
Young, J. C., and Hartl, F. U. (2000) Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23. EMBO J. 19, 5930-5940
-
(2000)
EMBO J.
, vol.19
, pp. 5930-5940
-
-
Young, J.C.1
Hartl, F.U.2
-
14
-
-
0037036458
-
cdc37
-
DOI 10.1074/jbc.M201287200
-
Siligardi, G., Panaretou, B., Meyer, P., Singh, S., Woolfson, D. N., Piper, P. W., Pearl, L. H., and Prodromou, C. (2002) Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. J. Biol. Chem. 277, 20151-20159 (Pubitemid 34967306)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.23
, pp. 20151-20159
-
-
Siligardi, G.1
Panaretou, B.2
Meyerc, P.3
Singh, S.4
Woolfson, D.N.5
Piper, P.W.6
Pearl, L.H.7
Prodromou, C.8
-
15
-
-
0035939668
-
Hsp90: A specialized but essential protein-folding tool
-
DOI 10.1083/jcb.200104079
-
Young, J. C., Moarefi, I., and Hartl, F. U. (2001) Hsp90: a specialized but essential protein-folding tool. J. Cell Biol. 154, 267-273 (Pubitemid 34286138)
-
(2001)
Journal of Cell Biology
, vol.154
, Issue.2
, pp. 267-273
-
-
Young, J.C.1
Moarefi, I.2
Ulrich, H.F.3
-
16
-
-
33646127577
-
Molecular chaperones and protein quality control
-
Bukau, B., Weissman, J., and Horwich, A. (2006) Molecular chaperones and protein quality control. Cell 125, 443-451
-
(2006)
Cell
, vol.125
, pp. 443-451
-
-
Bukau, B.1
Weissman, J.2
Horwich, A.3
-
17
-
-
0029973294
-
Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells
-
DOI 10.1210/me.10.6.705
-
Whitesell, L., and Cook, P. (1996) Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells. Mol. Endocrinol. 10, 705-712 (Pubitemid 26176278)
-
(1996)
Molecular Endocrinology
, vol.10
, Issue.6
, pp. 705-712
-
-
Whitesell, L.1
Cook, P.2
-
18
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
DOI 10.1172/JCI29715
-
Dickey, C. A., Kamal, A., Lundgren, K., Klosak, N., Bailey, R. M., Dunmore, J., Ash, P., Shoraka, S., Zlatkovic, J., Eckman, C. B., Patterson, C., Dickson, D. W., Nahman, N. S., Jr., Hutton, M., Burrows, F., and Petrucelli, L. (2007) The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J. Clin. Invest. 117, 648-658 (Pubitemid 46348523)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.3
, pp. 648-658
-
-
Dickey, C.A.1
Kamal, A.2
Lundgren, K.3
Klosak, N.4
Bailey, R.M.5
Dunmore, J.6
Ash, P.7
Shoraka, S.8
Zlatkovic, J.9
Eckman, C.B.10
Patterson, C.11
Dickson, D.W.12
Nahman Jr., N.S.13
Hutton, M.14
Burrows, F.15
Petrucelli, L.16
-
19
-
-
18844406200
-
Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation
-
DOI 10.1042/BJ20041283
-
Harst, A., Lin, H., and Obermann, W. M. (2005) Aha1 competes with Hop, p50, and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation. Biochem. J. 387, 789-796 (Pubitemid 40685714)
-
(2005)
Biochemical Journal
, vol.387
, Issue.3
, pp. 789-796
-
-
Harst, A.1
Lin, H.2
Obermann, W.M.J.3
-
20
-
-
0036923905
-
Aha, Another Regulator for Hsp90 Chaperones
-
DOI 10.1016/S1097-2765(02)00793-1
-
Mayer, M. P., Nikolay, R., and Bukau, B. (2002) Aha, another regulator for hsp90 chaperones. Mol. Cell 10, 1255-1256 (Pubitemid 36050863)
-
(2002)
Molecular Cell
, vol.10
, Issue.6
, pp. 1255-1256
-
-
Mayer, M.P.1
Nikolay, R.2
Bukau, B.3
-
21
-
-
33750842131
-
Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis
-
DOI 10.1016/j.cell.2006.09.043, PII S009286740601378X
-
Wang, X., Venable, J., LaPointe, P., Hutt, D. M., Koulov, A. V., Coppinger, J., Gurkan, C., Kellner, W., Matteson, J., Plutner, H., Riordan, J. R., Kelly, J. W., Yates, J. R., 3rd, and Balch, W. E. (2006) Hsp90 co-chaperone Aha1 down-regulation rescues misfolding of CFTR in cystic fibrosis. Cell 127, 803-815 (Pubitemid 44716255)
-
(2006)
Cell
, vol.127
, Issue.4
, pp. 803-815
-
-
Wang, X.1
Venable, J.2
LaPointe, P.3
Hutt, D.M.4
Koulov, A.V.5
Coppinger, J.6
Gurkan, C.7
Kellner, W.8
Matteson, J.9
Plutner, H.10
Riordan, J.R.11
Kelly, J.W.12
Yates III, J.R.13
Balch, W.E.14
-
22
-
-
79955759163
-
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics
-
Jinwal, U. K., Trotter, J. H., Abisambra, J. F., Koren, J., 3rd, Lawson, L. Y., Vestal, G. D., O'Leary, J. C., 3rd, Johnson, A. G., Jin, Y., Jones, J. R., Li, Q., Weeber, E. J., and Dickey, C. A. (2011) The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. J. Biol. Chem. 286, 16976-16983
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 16976-16983
-
-
Jinwal, U.K.1
Trotter, J.H.2
Abisambra, J.F.3
Koren III, J.4
Lawson, L.Y.5
Vestal, G.D.6
O'Leary III, J.C.7
Johnson, A.G.8
Jin, Y.9
Jones, J.R.10
Li, Q.11
Weeber, E.J.12
Dickey, C.A.13
-
23
-
-
0037176746
-
The metabolites of the mangrove fungus Verruculina enalia No. 2606 from a salt lake in the Bahamas
-
DOI 10.1016/S0031-9422(01)00470-8, PII S0031942201004708
-
Lin, Y., Wu, X., Deng, Z., Wang, J., Zhou, S., Vrijmoed, L. L., and Jones, E. B. (2002) The metabolites of the mangrove fungus Verruculina enalia no. 2606 from a salt lake in the Bahamas. Phytochemistry 59, 469-471 (Pubitemid 34202569)
-
(2002)
Phytochemistry
, vol.59
, Issue.4
, pp. 469-471
-
-
Lin, Y.1
Wu, X.2
Deng, Z.3
Wang, J.4
Zhou, S.5
Vrijmoed, L.L.P.6
Jones, E.B.G.7
-
24
-
-
77952779305
-
Hsc70 rapidly engages tau after microtubule destabilization
-
Jinwal, U. K., O'Leary, J. C., 3rd, Borysov, S. I., Jones, J. R., Li, Q., Koren, J., 3rd, Abisambra, J. F., Vestal, G. D., Lawson, L. Y., Johnson, A. G., Blair, L. J., Jin, Y., Miyata, Y., Gestwicki, J. E., and Dickey, C. A. (2010) Hsc70 rapidly engages tau after microtubule destabilization. J. Biol. Chem. 285, 16798-16805
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 16798-16805
-
-
Jinwal, U.K.1
O'Leary III, J.C.2
Borysov, S.I.3
Jones, J.R.4
Li, Q.5
Koren III, J.6
Abisambra, J.F.7
Vestal, G.D.8
Lawson, L.Y.9
Johnson, A.G.10
Blair, L.J.11
Jin, Y.12
Miyata, Y.13
Gestwicki, J.E.14
Dickey, C.A.15
-
25
-
-
74949110831
-
The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules
-
Jinwal, U. K., Koren, J., 3rd, Borysov, S. I., Schmid, A. B., Abisambra, J. F., Blair, L. J., Johnson, A. G., Jones, J. R., Shults, C. L., O'Leary, J. C., 3rd, Jin, Y., Buchner, J., Cox, M. B., and Dickey, C. A. (2010) The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules. J. Neurosci. 30, 591-599
-
(2010)
J. Neurosci.
, vol.30
, pp. 591-599
-
-
Jinwal, U.K.1
Koren III, J.2
Borysov, S.I.3
Schmid, A.B.4
Abisambra, J.F.5
Blair, L.J.6
Johnson, A.G.7
Jones, J.R.8
Shults, C.L.9
O'Leary III, J.C.10
Jin, Y.11
Buchner, J.12
Cox, M.B.13
Dickey, C.A.14
-
26
-
-
38349153572
-
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
-
Zhang, T., Hamza, A., Cao, X., Wang, B., Yu, S., Zhan, C. G., and Sun, D. (2008) A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol. Cancer Ther. 7, 162-170
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 162-170
-
-
Zhang, T.1
Hamza, A.2
Cao, X.3
Wang, B.4
Yu, S.5
Zhan, C.G.6
Sun, D.7
-
27
-
-
0029665779
-
Mammalian p50(Cdc37) is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4
-
Stepanova, L., Leng, X., Parker, S. B., and Harper, J. W. (1996) Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 10, 1491-1502 (Pubitemid 26260706)
-
(1996)
Genes and Development
, vol.10
, Issue.12
, pp. 1491-1502
-
-
Stepanova, L.1
Leng, X.2
Parker, S.B.3
Wade, H.J.4
-
28
-
-
0042527167
-
Cdc37 goes beyond Hsp90 and kinases
-
DOI 10.1379/1466-1268(2003)008<0114:CGBHAK>2.0.CO;2
-
MacLean, M., and Picard, D. (2003) Cdc37 goes beyond Hsp90 and kinases. Cell Stress Chaperones 8, 114-119 (Pubitemid 36993177)
-
(2003)
Cell Stress and Chaperones
, vol.8
, Issue.2
, pp. 114-119
-
-
MacLean, M.1
Picard, D.2
-
29
-
-
70349987102
-
Tau fragmentation, aggregation and clearance: The dual role of lysosomal processing
-
Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E. M., Cuervo, A. M., and Mandelkow, E. (2009) Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum. Mol. Genet. 18, 4153-4170
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4153-4170
-
-
Wang, Y.1
Martinez-Vicente, M.2
Krüger, U.3
Kaushik, S.4
Wong, E.5
Mandelkow, E.M.6
Cuervo, A.M.7
Mandelkow, E.8
-
30
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., and Levine, B. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672-676 (Pubitemid 129516338)
-
(1999)
Nature
, vol.402
, Issue.6762
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
31
-
-
34447103093
-
TDP-43 proteinopathy: The neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease
-
DOI 10.1007/s00401-007-0226-5
-
Kwong, L. K., Neumann, M., Sampathu, D. M., Lee, V. M., and Trojanowski, J. Q. (2007) TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathol. 114, 63-70 (Pubitemid 47029061)
-
(2007)
Acta Neuropathologica
, vol.114
, Issue.1
, pp. 63-70
-
-
Kwong, L.K.1
Neumann, M.2
Sampathu, D.M.3
Lee, V.M.-Y.4
Trojanowski, J.Q.5
-
32
-
-
77951540816
-
Caspase activation precedes and leads to tangles
-
de Calignon, A., Fox, L. M., Pitstick, R., Carlson, G. A., Bacskai, B. J., Spires-Jones, T. L., and Hyman, B. T. (2010) Caspase activation precedes and leads to tangles. Nature 464, 1201-1204
-
(2010)
Nature
, vol.464
, pp. 1201-1204
-
-
De Calignon, A.1
Fox, L.M.2
Pitstick, R.3
Carlson, G.A.4
Bacskai, B.J.5
Spires-Jones, T.L.6
Hyman, B.T.7
-
33
-
-
0033977687
-
Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium
-
DOI 10.1002/(SICI)1097-4547(20000101)59:1<24::AID-JNR4>3.0.CO;2-8
-
D'Mello, S. R., Kuan, C. Y., Flavell, R. A., and Rakic, P. (2000) Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium. J. Neurosci. Res. 59, 24-31 (Pubitemid 30038861)
-
(2000)
Journal of Neuroscience Research
, vol.59
, Issue.1
, pp. 24-31
-
-
D'Mello, S.R.1
Kuan, C.-Y.2
Flavell, R.A.3
Rakic, P.4
-
34
-
-
0032747486
-
Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease: Evidence for apoptotic cell death
-
Stadelmann, C., Deckwerth, T. L., Srinivasan, A., Bancher, C., Brück, W., Jellinger, K., and Lassmann, H. (1999) Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease: evidence for apoptotic cell death. Am. J. Pathol. 155, 1459-1466
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 1459-1466
-
-
Stadelmann, C.1
Deckwerth, T.L.2
Srinivasan, A.3
Bancher, C.4
Brück, W.5
Jellinger, K.6
Lassmann, H.7
-
35
-
-
77954571538
-
A caspase cleaved form of tau is preferentially degraded through the autophagy pathway
-
Dolan, P. J., and Johnson, G. V. (2010) A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J. Biol. Chem. 285, 21978-21987
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 21978-21987
-
-
Dolan, P.J.1
Johnson, G.V.2
-
36
-
-
0034463072
-
Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation
-
DOI 10.1210/me.14.8.1175
-
Rycyzyn, M. A., Reilly, S. C., O'Malley, K., and Clevenger, C. V. (2000) Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation. Mol. Endocrinol. 14, 1175-1186 (Pubitemid 32260479)
-
(2000)
Molecular Endocrinology
, vol.14
, Issue.8
, pp. 1175-1186
-
-
Rycyzyn, M.A.1
Reilly, S.C.2
O'Malley, K.3
Clevenger, C.V.4
-
37
-
-
0035818999
-
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
-
DOI 10.1038/414652a
-
Ye, Y., Meyer, H. H., and Rapoport, T. A. (2001) The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 414, 652-656 (Pubitemid 33151262)
-
(2001)
Nature
, vol.414
, Issue.6864
, pp. 652-656
-
-
Ye, Y.1
Meyer, H.H.2
Rapoport, T.A.3
-
38
-
-
0025157272
-
The specific DNA binding activity of the dioxin receptor is modulated by the 90-kDa heat shock protein
-
Wilhelmsson, A., Cuthill, S., Denis, M., Wikström, A. C., Gustafsson, J. A., and Poellinger, L. (1990) The specific DNA binding activity of the dioxin receptor is modulated by the 90-kDa heat shock protein. EMBO J. 9, 69-76
-
(1990)
EMBO J.
, vol.9
, pp. 69-76
-
-
Wilhelmsson, A.1
Cuthill, S.2
Denis, M.3
Wikström, A.C.4
Gustafsson, J.A.5
Poellinger, L.6
-
39
-
-
0025171925
-
Nuclear localization of two steroid receptor-associated proteins, hsp90 and p59
-
Gasc, J. M., Renoir, J. M., Faber, L. E., Delahaye, F., and Baulieu, E. E. (1990) Nuclear localization of two steroid receptor-associated proteins, hsp90 and p59. Exp. Cell Res. 186, 362-367
-
(1990)
Exp. Cell Res.
, vol.186
, pp. 362-367
-
-
Gasc, J.M.1
Renoir, J.M.2
Faber, L.E.3
Delahaye, F.4
Baulieu, E.E.5
-
40
-
-
0027106265
-
Control of steroid receptor function and cytoplasmic-nuclear transport by heat shock proteins
-
Pratt, W. B. (1992) Control of steroid receptor function and cytoplasmic-nuclear transport by heat shock proteins. Bioessays 14, 841-848
-
(1992)
Bioessays
, vol.14
, pp. 841-848
-
-
Pratt, W.B.1
-
41
-
-
3042631024
-
Gene regulation and DNA damage in the ageing human brain
-
DOI 10.1038/nature02661
-
Lu, T., Pan, Y., Kao, S. Y., Li, C., Kohane, I., Chan, J., and Yankner, B. A. (2004) Gene regulation and DNA damage in the ageing human brain. Nature 429, 883-891 (Pubitemid 38843301)
-
(2004)
Nature
, vol.429
, Issue.6994
, pp. 883-891
-
-
Lu, T.1
Pan, Y.2
Kao, S.-Y.3
Li, C.4
Kohane, I.5
Chan, J.6
Yankner, B.A.7
-
42
-
-
77956274584
-
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
-
Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., Xavier, R. J., Li, C., Yankner, B. A., Scherzer, C. R., and Yuan, J. (2010) Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 107, 14164-14169
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 14164-14169
-
-
Lipinski, M.M.1
Zheng, B.2
Lu, T.3
Yan, Z.4
Py, B.F.5
Ng, A.6
Xavier, R.J.7
Li, C.8
Yankner, B.A.9
Scherzer, C.R.10
Yuan, J.11
-
43
-
-
0034613294
-
Age-related decline in chaperone-mediated autophagy
-
Cuervo, A. M., and Dice, J. F. (2000) Age-related decline in chaperone-mediated autophagy. J. Biol. Chem. 275, 31505-31513
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 31505-31513
-
-
Cuervo, A.M.1
Dice, J.F.2
-
44
-
-
0141976246
-
Autophagy and aging: When "all you can eat" is yourself
-
Cuervo, A. M. (2003) Autophagy and aging: when "all you can eat" is yourself. SAGE KE 2003, pe25
-
(2003)
SAGE KE
, vol.2003
-
-
Cuervo, A.M.1
-
45
-
-
0037131187
-
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
-
DOI 10.1074/jbc.M206322200
-
Basso, A. D., Solit, D. B., Chiosis, G., Giri, B., Tsichlis, P., and Rosen, N. (2002) Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J. Biol. Chem. 277, 39858-39866 (Pubitemid 35190971)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.42
, pp. 39858-39866
-
-
Basso, A.D.1
Solit, D.B.2
Chiosis, G.3
Giri, B.4
Tsichlis, P.5
Rosen, N.6
-
46
-
-
80051729441
-
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy
-
Joo, J. H., Dorsey, F. C., Joshi, A., Hennessy-Walters, K. M., Rose, K. L., McCastlain, K., Zhang, J., Iyengar, R., Jung, C. H., Suen, D. F., Steeves, M. A., Yang, C. Y., Prater, S. M., Kim, D. H., Thompson, C. B., Youle, R. J., Ney, P. A., Cleveland, J. L., and Kundu, M. (2011) Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol. Cell 43, 572-585
-
(2011)
Mol. Cell
, vol.43
, pp. 572-585
-
-
Joo, J.H.1
Dorsey, F.C.2
Joshi, A.3
Hennessy-Walters, K.M.4
Rose, K.L.5
McCastlain, K.6
Zhang, J.7
Iyengar, R.8
Jung, C.H.9
Suen, D.F.10
Steeves, M.A.11
Yang, C.Y.12
Prater, S.M.13
Kim, D.H.14
Thompson, C.B.15
Youle, R.J.16
Ney, P.A.17
Cleveland, J.L.18
Kundu, M.19
-
47
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim, J., Kundu, M., Viollet, B., and Guan, K. L. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13, 132-141
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
|