Hyperbranched-hyperbranched polymeric nanoassembly to mediate controllable co-delivery of siRNA and drug for synergistic tumor therapy

Journal of Controlled Release

Volumn 216, Issue , 2015, Pages 9-17

  Jia, Hui Zhen ^a   Zhang, Wei ^b   Zhu, Jun Yi ^b   Yang, Bin ^a   Chen, Si ^a   Chen, Gang ^b   Zhao, Yi Fang ^b   Feng, Jun ^a   Zhang, Xian Zheng ^a  

^a WUHAN UNIVERSITY   (China)

^b Wuhan University   (China)

Author keywords

Combinational therapy; Core corona nanostructure; Drug siRNA co delivery; Hyperbranched polymer; pH sensitivity

Indexed keywords

AMPHIBIOUS VEHICLES; CHEMOTHERAPY; DENDRIMERS; DRUG THERAPY; POLYMERS; SELF ASSEMBLY; TUMORS;

CO DELIVERIES; COMBINATIONAL THERAPY; CORE CORONAS; HYPERBRANCHED POLYMERS; PH SENSITIVITY;

GENE THERAPY;

1,3 DIOL RICH HYPERBRANCHED POLYGLYCEROL; BECLIN 1; BENZENEBORONIC ACID; DOXORUBICIN; OLIGOETHYLENIMINE; POLYMER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, MOUSE; CROSS LINKING REAGENT; DELAYED RELEASE FORMULATION; NANOMATERIAL;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CHEMOTHERAPY; CANCER GROWTH; CELL KILLING; CELL MEMBRANE; CELL STRESS; CELL TRANSPORT; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENTIATION; DRUG RELEASE; DRUG TRANSPORT; GENE EXPRESSION; GENETIC TRANSFECTION; HELA CELL LINE; HYDROPHOBICITY; IN VITRO STUDY; INTERNALIZATION; LYSOSOME; MALE; MOUSE; MTT ASSAY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR MICROENVIRONMENT; WESTERN BLOTTING; ZETA POTENTIAL; ANIMAL; BAGG ALBINO MOUSE; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; GENE THERAPY; GENETICS; NEOPLASMS; NUDE MOUSE; PROCEDURES; TUMOR CELL LINE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; GENETIC THERAPY; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOSTRUCTURES; NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84939511108     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.08.006     Document Type: Article

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