Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs

Biomaterials

Volumn 35, Issue 13, 2014, Pages 4213-4222

  Zhu, Lin ^a,b   Perche, Federico ^a   Wang, Tao ^a   Torchilin, Vladimir P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Matrix metalloproteinase; Polymeric micelles; Self assembly; SiRNA and drug delivery; Stimulus sensitive; Tumor targeting

Indexed keywords

ANTI-TUMOR ACTIVITIES; CELL INTERNALIZATION; ENHANCED PERMEABILITY AND RETENTION EFFECTS; MATRIX METALLOPROTEINASE-2; MATRIX METALLOPROTEINASES; POLYMERIC MICELLE; STIMULUS-SENSITIVE; TUMOR TARGETING;

DRUG DELIVERY; ENZYME INHIBITION; HYDROPHOBICITY; MICELLES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMERS; SELF ASSEMBLY;

TUMORS;

1 2 DIOLEOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; COPOLYMER; GELATINASE A; GLYCEROPHOSPHOLIPID; LIPID; NANOCARRIER; PACLITAXEL; POLYETHYLENEIMINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DIOLEOYL-N-(MONOMETHOXYPOLYETHYLENE GLYCOL SUCCINYL)PHOSPHATIDYLETHANOLAMINE; MACROGOL DERIVATIVE; MICELLE; PHOSPHATIDYLETHANOLAMINE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; DRUG RELEASE; DRUG SOLUBILITY; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MALE; MICELLE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; SOLUBILIZATION; TARGET CELL; TUMOR CELL; UPREGULATION; CHEMICAL PHENOMENA; CHEMISTRY; GENETICS; PROCEDURES; TUMOR CELL LINE;

CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MATRIX METALLOPROTEINASE 2; MICELLES; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; POLYMERS; RNA, SMALL INTERFERING;

EID: 84896708224     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.01.060     Document Type: Article

References (25)

1. Song E., Lee S.K., Wang J., Ince N., Ouyang N., Min J., et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003, 9:347-351.
2. de Fougerolles A., Vornlocher H.P., Maraganore J., Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov 2007, 6:443-453.
3. Oh Y.K., Park T.G. siRNA delivery systems for cancer treatment. Adv Drug Deliv Rev 2009, 61:850-862.
4. De Paula D., Bentley M.V., Mahato R.I. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. Rna 2007, 13:431-456.
5. Zhu L., Mahato R.I. Lipid and polymeric carrier-mediated nucleic acid delivery. Expert Opin Drug Deliv 2010, 7:1209-1226.
6. Sawant R.R., Sriraman S.K., Navarro G., Biswas S., Dalvi R.A., Torchilin V.P. Polyethyleneimine-lipid conjugate-based pH-sensitive micellar carrier for gene delivery. Biomaterials 2012, 33:3942-3951.
7. Navarro G., Sawant R.R., Biswas S., Essex S., Tros de Ilarduya C., Torchilin V.P. P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells. Nanomedicine (Lond) 2012, 7:65-78.
8. Wang Y., Gao S., Ye W.H., Yoon H.S., Yang Y.Y. Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer. Nat Mater 2006, 5:791-796.
9. Sun T.M., Du J.Z., Yao Y.D., Mao C.Q., Dou S., Huang S.Y., et al. Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression. ACS Nano 2011, 5:1483-1494.
10. Chen A.M., Zhang M., Wei D., Stueber D., Taratula O., Minko T., et al. Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells. Small 2009, 5:2673-2677.
11. Zhu L., Torchilin V.P. Stimulus-responsive nanopreparations for tumor targeting. Integr Biol 2013, 5:96-107.
12. Zhu L., Kate P., Torchilin V.P. Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting. ACS Nano 2012, 6:3491-3498.
13. Zhu L., Wang T., Perche F., Taigind A., Torchilin V.P. Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety. Proc Natl Acad Sci U S A 2013, 110:17047-17052.
14. Kortylewski M., Kujawski M., Wang T., Wei S., Zhang S., Pilon-Thomas S., et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005, 11:1314-1321.
15. Lukyanov A.N., Torchilin V.P. Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv Drug Deliv Rev 2004, 56:1273-1289.
16. Walkey C.D., Olsen J.B., Guo H., Emili A., Chan W.C. Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. JAm Chem Soc 2012, 134:2139-2147.
17. Ambrosini G., Adida C., Altieri D.C. Anovel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997, 3:917-921.
18. Altieri D.C. Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene 2003, 22:8581-8589.
19. Zhu L., Mahato R.I. Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation. Bioconjug Chem 2010, 21:2119-2127.
20. Li S.-D., Huang L. Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Mol Pharmacol 2006, 3:579-588.
21. Salzano G., Riehle R., Navarro G., Perche F., De Rosa G., Torchilin V.P. Polymeric micelles containing reversibly phospholipid-modified anti-survivin siRNA: a promising strategy to overcome drug resistance in cancer. Cancer Lett 2014, 343:224-231.
22. Shen J., Yin Q., Chen L., Zhang Z., Li Y. Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer. Biomaterials 2012, 33:8613-8624.
23. Kirpotin D.B., Drummond D.C., Shao Y., Shalaby M.R., Hong K., Nielsen U.B., et al. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 2006, 66:6732-6740.
24. Zorko M., Langel U. Cell-penetrating peptides: mechanism and kinetics of cargo delivery. Adv Drug Deliv Rev 2005, 57:529-545.
25. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 2011, 6:815-823.