Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure

Journal of the American Heart Association

Volumn 3, Issue 6, 2014, Pages

  Lee, Rebecca ^a   Xu, Bin ^b   Eduardo Rame, J ^a   Felkin, Leanne E ^c   Barton, Paul ^c   Dries, Daniel L ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Atrial natriuretic factor; Genes; Heart failure; Molecular biology; Myocytes; Natriuretic peptides

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CORIN MESSENGER RNA; DACTINOMYCIN; MESSENGER RNA; PROTEIN IRE1; REGULATED INOSITOL REQUIRING PROTEIN 1 DEPENDENT DECAY; RIBONUCLEASE; SHORT HAIRPIN RNA; THAPSIGARGIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; CORIN PROTEIN, HUMAN; CORIN PROTEIN, MOUSE; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; ERN1 PROTEIN, MOUSE; PROTEIN PRECURSOR; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SERINE PROTEINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE SILENCING; HEART CELL CULTURE; HEART MUSCLE CELL; HEART TRANSPLANTATION; HL 1 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN PROCESSING; RAT; RNA INTERFERENCE; RNA STABILITY; SYSTOLIC HEART FAILURE; TRANSCRIPTION REGULATION; ANIMAL; DEFICIENCY; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HEART FAILURE; HEART MUSCLE; HEK293 CELL LINE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; TIME;

ANIMALS; ATRIAL NATRIURETIC FACTOR; DNA-BINDING PROTEINS; DOWN-REGULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART FAILURE; HEK293 CELLS; HUMANS; MICE; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; RNA STABILITY; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84939461706     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.114.001104     Document Type: Article

References (39)

1. Burnett JC Jr. Novel therapeutic directions for the natriuretic peptides in cardiovascular diseases: what's on the horizon. J Cardiol. 2006;48:235-241.
2. Kuhn M. Cardiac and intestinal natriuretic peptides: insights from genetically modified mice. Peptides. 2005;26:1078-1085.
3. Potter LR, Abbey-Hosch S, Dickey DM. Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions. Endocr Rev. 2006;27:47-72.
4. Calvieri C, Rubattu S, Volpe M. Molecular mechanisms underlying cardiac antihypertrophic and antifibrotic effects of natriuretic peptides. J Mol Med. 2012;90:5-13.
5. Holtwick R, van Eickels M, Skryavin Baba HA, Bubikat A, Begrow F, Schneider MD, Garbers DL, Kuhn M. Pressure independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase A. J Clin Invest. 2003;111:1399-1407.
6. Kuhn M. Molecular physiology of natriuretic peptide signalling. Basic Res Cardiol. 2004;99:76-82.
7. Knappe S, Wu F, Masikat MR, Morser J, Wu Q. Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin. J Biol Chem. 2003;278:52363-52370.
8. Wu Q. The serine protease corin in cardiovascular biology and disease. Front Biosci. 2007;12:4179-4190.
9. Dries DL. Process matters: emerging concepts underlying impaired natriuretic peptide system function in heart failure. Circ Heart Fail. 2011;4:107-110.
10. Giuliani I, Rieunier F, Larue C, Delagneau JF, Granier C, Pau B, Ferriere M, Saussine M, Cristol JP, Dupuy AM, Merigeon E, Merle D, Villard S. Assay for measurement of intact B-type natriuretic peptide prohormone in blood. Clin Chem. 2006;52:1054-1061.
11. Dries DL, Ky B, Wu AH, Rame JE, Putt ME, Cappola TP. Simultaneous assessment of unprocessed ProBNP1-108 in addition to processed BNP32 improves identification of high-risk ambulatory patients with heart failure. Circ Heart Fail. 2010;3:220-227.
12. Heublein DM. Immunoreactivity and cyclic GMP activating actions of various molecular forms of human B-type natriuretic peptide. Hypertension. 2007;49:1114-1119.
13. Liang F, O'Rear J, Schellenberger U, Tai L, Lasecki M, Schreiner GF, Apple FS, Maisel AS, Pollitt NS, Protter AA. Evidence for functional heterogeneity of circulating B-type natriuretic peptide. J Am Coll Cardiol. 2007;49:1071-1078.
14. Tsutamoto T, Kanamori T, Wada A, Kinoshita M. Uncoupling of atrial natriuretic peptide extraction and cyclic guanosine monophosphate production in the pulmonary circulation in patients with severe heart failure. J Am Coll Cardiol. 1992;20:541-546.
15. Tsutamoto T, Wada A, Maeda K, Hisanaga T, Maeda Y, Fukai D, Ohnishi M, Sugimoto Y, Kinoshita M. Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. Circulation. 1997;96:509-516.
16. Hollien J, Lin JH, Li H, Stevens N, Walter P, Weissman JS. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 2009;186:323-331.
17. Hollien J, Weissman JS. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science. 2006;313:104-107.
18. Lipson KL, Ghosh R, Urano F. The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells. PLoS One. 2008;3:e1648.
19. Ackermann U, Deliva RD. Reduced baroreceptor sensitivity during hypotension in ANP-knockout mice. Can J Physiol Pharmacol. 2001;79:201-205.
20. Okada K, Minamino T, Tsukamoto Y, Liao Y, Tsukamoto O, Takashima S, Hirata A, Fujita M, Nagamachi Y, Nakatani T, Yutani C, Ozawa K, Ogawa S, Tomoike H, Hori M, Kitakaze M. Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis. Circulation. 2004;110:705-712.
21. Toth A, Nickson P, Mandl A, Bannister ML, Toth K, Erhardt P. Endoplasmic reticulum stress as a novel therapeutic target in heart diseases. Cardiovasc Hematol Disord Drug Targets. 2007;7:205-218.
22. Sawada T, Minamino T, Fu HY, Asai M, Okuda K, Isomura T, Yamazaki S, Asano Y, Okada K, Tsukamoto O, Sanada S, Asanuma H, Asakura M, Takashima S, Kitakaze M, Komuro I. X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes. J Mol Cell Cardiol. 2010;48:1280-1289.
23. Dries DL, Margulies KM, Cappola TP. Corin gene expression inversely related to increased BNP expression in advanced cardiomyopathy: setting the stage for inefficient natriuretic peptide processing in heart failure? Circulation. 2005;112:637.
24. Felkin LE, Taegtmeyer AB, Barton PJ. Real-time quantitative polymerase chain reaction in cardiac transplant research. Methods Mol Biol. 2006;333:305-330.
25. Felkin LE, Lara-Pezzi EA, Hall JL, Birks EJ, Barton PJ. Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression. Cardiovasc Transl Res. 2011;4:321-331.
26. Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A, Izzo NJ Jr. Hl-1 cells: A cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proceedings of the National Academy of Sciences of the United States of America 1998;95:2979-2984.
27. Hetz C, Glimcher LH. Fine-tuning of the unfolded protein response: assembling the IRE1alpha interactome. Mol Cell. 2009;35:551-561.
28. Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007;8:519-529.
29. Mori K. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell. 2000;101:451-454.
30. Merksamer PI, Papa FR. The UPR and cell fate at a glance. J Cell Sci. 2010;123:1003-1006.
31. Aragon T, van Anken E, Pincus D, Serafimova IM, Korennykh AV, Rubio CA, Walter P. Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature. 2009;457:736-740.
32. Dickey DM, Potter LR. ProBNP(1-108) is resistant to degradation and activates guanylyl cyclase-A with reduced potency. Clin Chem. 2011;57:1272-1278.
33. Gladysheva IP, Wang D, McNamee RA, Houng AK, Mohamad AA, Fan TM, Reed GL. Corin overexpression improves cardiac function, heart failure, and survival in mice with dilated cardiomyopathy. Hypertension. 2013;61:327-332.
34. Arakawa T, Ejima D, Kita Y, Tsumoto K. Small molecule pharmacological chaperones: from thermodynamic stabilization to pharmaceutical drugs. Biochim Biophys Acta. 2006;1764:1677-1687.
35. Asmellash S, Stevens JL, Ichimura T. Modulating the endoplasmic reticulum stress response with trans-4,5-dihydroxy-1,2-dithiane prevents chemically induced renal injury in vivo. Toxicol Sci. 2005;88:576-584.
36. Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 2013;144:989-1000.e6.
37. de Almeida SF, Picarote G, Fleming JV, Carmo-Fonseca M, Azevedo JE, de Sousa M. Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation. J Biol Chem. 2007;282:27905-27912.
38. Hu WK, Liu R, Pei H, Li B. Endoplasmic reticulum stress-related factors protect against diabetic retinopathy. Exp Diabetes Res. 2012;2012:507986.
39. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006;313:1137-1140.