Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

Journal of Hepatology

Volumn 63, Issue 3, 2015, Pages 670-678

  Bárcena, Cristina ^a,b   Stefanovic, Milica ^a,b   Tutusaus, Anna ^a,b   Joannas, Leonel ^c   Menéndez, Anghara ^b   García Ruiz, Carmen ^a,b   Sancho Bru, Pau ^a   Marí, Montserrat ^a,b   Caballeria, Joan ^a   Rothlin, Carla V ^c   Fernández Checa, José C ^a,b,d   De Frutos, Pablo García ^b   Morales, Albert ^a,b  

^a HOSPITAL CLÍNIC   (Spain)

^b INST D INVESTIGACIONS B   (Spain)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Chronic liver patients; Experimental fibrosis; Gas6 Axl serum levels; HSC activation; TAM receptors

Indexed keywords

BGB 324; CARBON TETRACHLORIDE; GROWTH ARREST SPECIFIC PROTEIN 6; PROTEIN AXL; PROTEIN INHIBITOR; PROTEIN KINASE B; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; TAM RECEPTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; GROWTH ARREST-SPECIFIC PROTEIN 6; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MERTK PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE;

ADULT; ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; EXPERIMENTAL LIVER INJURY; FIBROGENESIS; HEPATITIS C; HUMAN; IN VITRO STUDY; LIVER DYSFUNCTION; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING; AGED; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CHRONIC DISEASE; HEPATIC STELLATE CELL; LIVER CIRRHOSIS; MIDDLE AGED; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADULT; AGED; ANIMALS; CARBON TETRACHLORIDE; CELL PROLIFERATION; CELLS, CULTURED; CHRONIC DISEASE; HEPATIC STELLATE CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; NF-KAPPA B; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 84939268793     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.04.013     Document Type: Article

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