Hydrogen deuterium mass spectrometry in drug discovery

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 18, 2015, Pages 3771-3776

  Campobasso, Nino ^a   Huddler, Donald ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Hydrogen deuterium exchange mass; spectrometry; Structural biology

Indexed keywords

ANALYTIC METHOD; ARTICLE; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DRUG BINDING SITE; DRUG PROTEIN BINDING; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PROTEIN STRUCTURE; TECHNOLOGY; X RAY CRYSTALLOGRAPHY; DRUG DEVELOPMENT; PROCEDURES;

DEUTERIUM EXCHANGE MEASUREMENT; DRUG DISCOVERY; MASS SPECTROMETRY;

EID: 84939267149     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.07.007     Document Type: Review

References (25)

1. J.J. Skinner, W.K. Lim, S. Bedard, B.E. Black, and S.W. Englander Protein Sci. 21 2012 987
2. J.J. Skinner, W.K. Lim, S. Bedard, B.E. Black, and S.W. Englander Protein Sci. 21 2012 996
3. Y. Tsutsui, and P.L. Wintrode Curr. Med. Chem. 14 2007 2344
4. C.W. Chung Acta Crystallogr. Part D: Biol. Crystallogr. 63 2007 62
5. P.W. Rose, C. Bi, W.F. Bluhm, C.H. Christie, D. Dimitropoulos, S. Dutta, R.K. Green, D.S. Goodsell, A. Prli-ç, M. Quesada, G.B. Quinn, A.G. Ramos, J.D. Westbrook, J. Young, C. Zardecki, H.M. Berman, and P.E. Bourne Nucleic Acids Res. 41 2013 D475
6. A. Politis, and A.J. Borysik Proteomics 2015
7. B.T. Walters, A. Ricciuti, L. Mayne, and S.W. Englander J. Am. Soc. Mass Spectrom. 23 2012 2132
8. Z.Y. Kan, B.T. Walters, L. Mayne, and S.W. Englander Proc. Natl. Acad. Sci. U.S.A. 110 2013 16438
9. L. Mayne, Z.Y. Kan, P.S. Chetty, A. Ricciuti, B.T. Walters, and S.W. Englander J. Am. Soc. Mass Spectrom. 2011 1898 22
10. M.J. Chalmers, S.A. Busby, B.D. Pascal, Y. He, C.L. Hendrickson, A.G. Marshall, and P.R. Griffin Anal. Chem. 78 2006 1005
11. R. Lindner, X. Lou, J. Reinstein, R.L. Shoeman, F.A. Hamprecht, and A. Winkler J. Am. Soc. Mass Spectrom. 25 2014 1018
12. B.D. Pascal, S. Willis, J.L. Lauer, R.R. Landgraf, G.M. West, D. Marciano, S. Novick, D. Goswami, M.J. Chalmers, and P.R. Griffin J. Am. Soc. Mass Spectrom. 23 2012 1512
13. Z.Y. Kan, L. Mayne, P.S. Chetty, and S.W. Englander J. Am. Soc. Mass Spectrom. 2011 1906 22
14. D.C. Rees, M. Congreve, C.W. Murray, and R. Carr Nat. Rev. Drug Disc. 3 2004 660
15. D. Pantazatos, J.S. Kim, H.E. Klock, R.C. Stevens, I.A. Wilson, S.A. Lesley, and V.L. Woods Jr. Proc. Natl. Acad. Sci. U.S.A. 101 2004 751
16. G. Spraggon, D. Pantazatos, H.E. Klock, I.A. Wilson, V.L. Woods Jr., and S.A. Lesley Protein Sci. 13 2004 3187
17. S. Sharma, H. Zheng, Y.J. Huang, A. Ertekin, Y. Hamuro, P. Rossi, R. Tejero, T.B. Acton, R. Xiao, M. Jiang, L. Zhao, L.C. Ma, G.V. Swapna, J.M. Aramini, and G.T. Montelione Proteins 76 2009 882
18. T. Sasaki, S. Takasuga, J. Sasaki, S. Kofuji, S. Eguchi, M. Yamazaki, and A. Suzuki Prog. Lipid Res. 48 2009 307
19. J.E. Burke, A.J. Inglis, O. Perisic, G.R. Masson, S.H. McLaughlin, F. Rutaganira, K.M. Shokat, and R.L. Williams Science 344 2014 1035
20. In: Structural Proteomics; Punta, M.; Simon, I.; Dosztányi, Z. (Eds.), Springer, 2015, pp 35-59.
21. J.H. Choi, A.S. Banks, T.M. Kamenecka, S.A. Busby, M.J. Chalmers, N. Kumar, D.S. Kuruvilla, Y. Shin, Y. He, J.B. Bruning, D.P. Marciano, M.D. Cameron, D. Laznik, M.J. Jurczak, S.C. Schurer, D. Vidovic, G.I. Shulman, B.M. Spiegelman, and P.R. Griffin Nature 477 2011 477
22. D.P. Marciano, V. Dharmarajan, and P.R. Griffin Curr. Opin. Struct. Biol 28 2014 105
23. L. Yang, D. Broderick, Y. Jiang, V. Hsu, and C.S. Maier Biochim. Biophys. Acta - Proteins Prot. 1844 2014 1684
24. D. Goswami, C. Callaway, B. Pascal, R. Kumar, D. Edwards, and P. Griffin Structure 22 2014 961
25. G. Hao, J.S. Wesolowski, X. Jiang, S. Lauder, and V.D. Sood J. Mol. Recognit. 28 2015 269