Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 388, Issue 9, 2015, Pages 953-963

  Zhang, Hong Feng ^a   Li, Ting Bo ^a   Liu, Bin ^a   Lou, Zheng ^a   Zhang, Jie Jie ^a   Peng, Jing Jie ^a   Zhang, Xiao Jie ^a   Ma, Qi Lin ^a,b   Peng, Jun ^a   Luo, Xiu Ju ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Ischemia reperfusion; Myosin regulatory light chain (MLC20); Myosin regulatory light chain kinase (MLCK); NADPH oxidase (NOX); Oxidative stress; Phosphorylation

Indexed keywords

CASPASE 3; MESSENGER RNA; MYOSIN LIGHT CHAIN KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; 1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; AZEPINE DERIVATIVE; CYBB PROTEIN, RAT; HYDROGEN PEROXIDE; MEMBRANE PROTEIN; MYOSIN LIGHT CHAIN; NAPHTHALENE DERIVATIVE; NOX4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MIXED LYMPHOCYTE CULTURE; MORTALITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; AZEPINES; BRAIN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; HYDROGEN PEROXIDE; MALE; MEMBRANE GLYCOPROTEINS; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN KINASE; NADPH OXIDASE; NAPHTHALENES; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; UP-REGULATION;

EID: 84939264926     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-015-1125-2     Document Type: Article

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