Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study

Journal of Hepatology

Volumn 63, Issue 3, 2015, Pages 634-642

  Lee, Karla C L ^a   Baker, Luisa A ^a   Stanzani, Giacomo ^a   Alibhai, Hatim ^a   Chang, Yu Mei ^a   Jimenez Palacios, Carolina ^a   Leckie, Pamela J ^b   Giordano, Paola ^a   Priestnall, Simon L ^a   Antoine, Daniel J ^c   Jenkins, Rosalind E ^c   Goldring, Christopher E ^c   Park, B Kevin ^c   Andreola, Fausto ^b   Agarwal, Banwari ^d   Mookerjee, Rajeshwar P ^b   Davies, Nathan A ^b   Jalan, Rajiv ^b  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Acetaminophen; Acute liver failure; Albumin; Endotoxin; Extracorporeal liver assist device; Toll like receptor 4; UCL LDD

Indexed keywords

ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CREATININE; ENDOTOXIN; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; PARACETAMOL; TOLL LIKE RECEPTOR 4; UREA; SERUM ALBUMIN;

ACUTE LIVER FAILURE; ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DIALYSIS EQUIPMENT AND SUPPLIES; DISEASE SEVERITY; ENDOTOXEMIA; KIDNEY FUNCTION; LIVER FUNCTION; LIVER SUPPORT; NONHUMAN; PORCINE MODEL; PRIORITY JOURNAL; RESPIRATORY FUNCTION; RISK REDUCTION; SIGNAL TRANSDUCTION; SURVIVAL; UNIVERSITY COLLEGE LONDON LIVER DIALYSIS DEVICE; VASOPLEGIA; ANIMAL; ARTIFICIAL LIVER; BLOOD; DEVICES; EXTRACORPOREAL CIRCULATION; FEMALE; ISOLATION AND PURIFICATION; LIVER FAILURE, ACUTE; METABOLISM; PHYSIOLOGY; PIG; SORPTION DETOXIFICATION;

ANIMALS; ENDOTOXINS; EXTRACORPOREAL CIRCULATION; FEMALE; HMGB1 PROTEIN; LIVER FAILURE, ACUTE; LIVER, ARTIFICIAL; SERUM ALBUMIN; SIGNAL TRANSDUCTION; SORPTION DETOXIFICATION; SWINE; TOLL-LIKE RECEPTOR 4;

EID: 84939264350     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.04.020     Document Type: Article

References (44)

1. K.J. Simpson, C.M. Bates, N.C. Henderson, S.J. Wigmore, O.J. Garden, A. Lee, and et al. The utilization of liver transplantation in the management of acute liver failure: comparison between acetaminophen and non-acetaminophen etiologies Liver Transpl 15 2009 600 609
2. Z.X. Liu, and N. Kaplowitz Role of innate immunity in acetaminophen-induced hepatotoxicity Expert Opin Drug Metab Toxicol 2 2006 493 503
3. J.J. Maher DAMPs ramp up drug toxicity J Clin Invest 119 2009 246 249
4. H. Jaeschke, C.D. Williams, A. Ramachandran, and M.L. Bajt Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity Liver Int 32 2012 8 20
5. G. Szabo, and T. Csak Inflammasomes in liver diseases J Hepatol 57 2012 642 654
6. G.L. Su, K.Q. Gong, M.H. Fan, W.M. Kelley, J. Hsieh, J.M. Sun, and et al. Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice Hepatology 41 2005 187 195
7. R. Jalan, K. Schnurr, R.P. Mookerjee, S. Sen, L. Cheshire, S. Hodges, and et al. Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality Hepatology 50 2009 555 564
8. K. Oettl, R. Birner-Gruenberger, W. Spindelboeck, H.P. Stueger, L. Dorn, V. Stadlbauer, and et al. Oxidative albumin damage in chronic liver failure: relation to albumin binding capacity, liver dysfunction and survival J Hepatol 59 2013 978 983
9. W.M. Lee, R.H. Squires Jr., S.L. Nyberg, E. Doo, and J.H. Hoofnagle Acute liver failure: summary of a workshop Hepatology 47 2008 1401 1415
10. D.J. Antoine, D.P. Williams, A. Kipar, R.E. Jenkins, S.L. Regan, J.G. Sathish, and et al. High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo Toxicol Sci 112 2009 521 531
11. A.B. Imaeda, A. Watanabe, M.A. Sohail, S. Mahmood, M. Mohamadnejad, F.S. Sutterwala, and et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome J Clin Invest 119 2009 305 314
12. B.V. Martin-Murphy, M.P. Holt, and C. Ju The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice Toxicol Lett 192 2010 387 394
13. P. Scaffidi, T. Misteli, and M.E. Bianchi Release of chromatin protein HMGB1 by necrotic cells triggers inflammation Nature 418 2002 191 195
14. N. Shah, M. Montes de Oca, M. Jover-Cobos, K. Tanamoto, M. Muroi, K. Sugiyama, and et al. Role of toll-like receptor 4 in mediating multiorgan dysfunction in mice with acetaminophen induced acute liver failure Liver Transpl 19 2013 751 761
15. G.L. Su, L.M. Hoesel, J. Bayliss, M.R. Hemmila, and S.C. Wang Lipopolysaccharide binding protein inhibitory peptide protects against acetaminophen-induced hepatotoxicity Am J Physiol Gastrointest Liver Physiol 299 2010 G1319 G1325
16. R. Garcia-Martinez, P. Caraceni, M. Bernardi, P. Gines, V. Arroyo, and R. Jalan Albumin: pathophysiologic basis of its role in the treatment of cirrhosis and its complications Hepatology 58 2013 1836 1846
17. S. Sen, N.A. Davies, R.P. Mookerjee, L.M. Cheshire, S.J. Hodges, R. Williams, and et al. Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study Liver Transpl 10 2004 1109 1119
18. S. Rademacher, M. Oppert, and A. Jorres Artificial extracorporeal liver support therapy in patients with severe liver failure Expert Rev Gastroenterol Hepatol 5 2011 591 599
19. R. Banares, F. Nevens, F.S. Larsen, R. Jalan, A. Albillos, M. Dollinger, and et al. Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the RELIEF trial Hepatology 57 2013 1153 1162
20. A. Kribben, G. Gerken, S. Haag, S. Herget-Rosenthal, U. Treichel, C. Betz, and et al. Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure Gastroenterology 142 2012 e783
21. K. Rifai, T. Ernst, U. Kretschmer, H. Haller, M.P. Manns, and D. Fliser Removal selectivity of Prometheus: a new extracorporeal liver support device World J Gastroenterol 12 2006 940 944
22. V. Stadlbauer, P. Krisper, R. Aigner, B. Haditsch, A. Jung, C. Lackner, and et al. Effect of extracorporeal liver support by MARS and Prometheus on serum cytokines in acute-on-chronic liver failure Crit Care 10 2006 R169
23. K. Oettl, V. Stadlbauer, P. Krisper, and R.E. Stauber Effect of extracorporeal liver support by molecular adsorbents recirculating system and Prometheus on redox state of albumin in acute-on-chronic liver failure Ther Apher Dial 13 2009 431 436
24. K.C. Lee, C. Palacios Jimenez, H. Alibhai, Y.M. Chang, P.J. Leckie, L.A. Baker, and et al. A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival Liver Int 33 2013 544 551
25. R. Jalan, S.W. Olde Damink, J.C. Ter Steege, D.N. Redhead, A. Lee, P.C. Hayes, and et al. Acute endotoxemia following transjugular intrahepatic stent-shunt insertion is associated with systemic and cerebral vasodilatation with increased whole body nitric oxide production in critically ill cirrhotic patients J Hepatol 54 2011 265 271
26. J.E. Fisher, T.J. McKenzie, J.B. Lillegard, Y. Yu, J.E. Juskewitch, G.I. Nedredal, and et al. Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure J Surg Res 180 2013 147 155
27. J.M. Millis, and J.E. Losanoff Technology insight: liver support systems Nat Clin Pract Gastroenterol Hepatol 2 2005 398 405
28. F. Saliba, C. Camus, F. Durand, P. Mathurin, A. Letierce, B. Delafosse, and et al. Albumin dialysis with a noncell artificial liver support device in patients with acute liver failure: a randomized, controlled trial Ann Intern Med 159 2013 522 531
29. A. Aggarwal, J.P. Ong, Z.M. Younossi, D.R. Nelson, L. Hoffman-Hogg, and A.C. Arroliga Predictors of mortality and resource utilization in cirrhotic patients admitted to the medical ICU Chest 119 2001 1489 1497
30. J. Vaquero, J. Polson, C. Chung, I. Helenowski, F.V. Schiodt, J. Reisch, and et al. Infection and the progression of hepatic encephalopathy in acute liver failure Gastroenterology 125 2003 755 764
31. R.P. Mookerjee, V. Stadlbauer, S. Lidder, G.A. Wright, S.J. Hodges, N.A. Davies, and et al. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome Hepatology 46 2007 831 840
32. P.M. Honore, R. Jacobs, O. Joannes-Boyau, J. De Regt, E. De Waele, V. van Gorp, and et al. Newly designed CRRT membranes for sepsis and SIRS-a pragmatic approach for bedside intensivists summarizing the more recent advances: a systematic structured review ASAIO J 59 2013 99 106
33. S. Morgera, D. Klonower, J. Rocktaschel, M. Haase, F. Priem, S. Ziemer, and et al. TNF-alpha elimination with high cut-off haemofilters: a feasible clinical modality for septic patients? Nephrol Dial Transpl 18 2003 1361 1369
34. S. Morgera, T. Slowinski, C. Melzer, V. Sobottke, O. Vargas-Hein, T. Volk, and et al. Renal replacement therapy with high-cutoff hemofilters: Impact of convection and diffusion on cytokine clearances and protein status Am J Kidney Dis 43 2004 444 453
35. S. Morgera, M. Haase, J. Rocktaschel, T. Bohler, O. Vargas-Hein, C. Melzer, and et al. Intermittent high-permeability hemofiltration modulates inflammatory response in septic patients with multiorgan failure Nephron Clin Pract 94 2003 c75 c80
36. S. Morgera, M. Haase, J. Rocktaschel, T. Bohler, C. von Heymann, O. Vargas-Hein, and et al. High permeability haemofiltration improves peripheral blood mononuclear cell proliferation in septic patients with acute renal failure Nephrol Dial Transpl 18 2003 2570 2576
37. S. Morgera, M. Haase, T. Kuss, O. Vargas-Hein, H. Zuckermann-Becker, C. Melzer, and et al. Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure Crit Care Med 34 2006 2099 2104
38. T. Rimmele, A. Assadi, M. Cattenoz, O. Desebbe, C. Lambert, E. Boselli, and et al. High-volume haemofiltration with a new haemofiltration membrane having enhanced adsorption properties in septic pigs Nephrol Dial Transpl 24 2009 421 427
39. M.A. D'Souza, A. Ravn, C. Jorns, G. Nowak, and B. Isaksson Membrane cut-off does not influence results regarding the measurement of small molecules - A comparative study between 20- and 100-kDa catheters in hepatic microdialysis Clin Physiol Funct Imaging 34 2014 109 113
40. M. Yumoto, O. Nishida, K. Moriyama, Y. Shimomura, T. Nakamura, N. Kuriyama, and et al. In vitro evaluation of high mobility group box 1 protein removal with various membranes for continuous hemofiltration Ther Apher Dial 15 2011 385 393
41. B. Lu, D.J. Antoine, K. Kwan, P. Lundback, H. Wahamaa, H. Schierbeck, and et al. JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation Proc Natl Acad Sci U S A 111 2014 3068 3073
42. S. Nystrom, D.J. Antoine, P. Lundback, J.G. Lock, A.F. Nita, K. Hogstrand, and et al. TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis EMBO J 32 2013 86 99
43. E. Venereau, M. Casalgrandi, M. Schiraldi, D.J. Antoine, A. Cattaneo, F. De Marchis, and et al. Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release J Exp Med 209 2012 1519 1528
44. H. Yang, P. Lundback, L. Ottosson, H. Erlandsson-Harris, E. Venereau, M.E. Bianchi, and et al. Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1) Mol Med 18 2012 250 259