A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival

Liver International

Volumn 33, Issue 4, 2013, Pages 544-551

  Lee, Karla C L ^a   Palacios Jimenez, Carolina ^a   Alibhai, Hatim ^a   Chang, Yu Mei ^a   Leckie, Pamela J ^b   Baker, Luisa A ^a   Stanzani, Giacomo ^a   Priestnall, Simon L ^a   Mookerjee, Rajeshwar P ^b   Jalan, Rajiv ^b   Davies, Nathan A ^b  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Acetaminophen; Acute liver failure; Intensive care; Intracranial hypertension; Large animal model; Pig

Indexed keywords

CREATININE; PARACETAMOL;

ACUTE LIVER FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING DISORDER; CARDIOVASCULAR DISEASE; CONTINUOUS RENAL REPLACEMENT THERAPY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE COURSE; ELECTROLYTE DISTURBANCE; FEMALE; HYPERAMMONEMIA; HYPERLACTATEMIA; INTENSIVE CARE; INTERMITTENT POSITIVE PRESSURE VENTILATION; INTRACRANIAL HYPERTENSION; LIVER NECROSIS; METABOLIC ACIDOSIS; MORTALITY; NONHUMAN; PROTHROMBIN TIME; SHOCK; SURVIVAL RATE; SURVIVAL TIME; SWINE;

ACETAMINOPHEN; ACID-BASE EQUILIBRIUM; ACIDOSIS; ANIMALS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DRUG-INDUCED LIVER INJURY; FEMALE; HEMODYNAMICS; INTENSIVE CARE; INTRACRANIAL PRESSURE; LIVER; LIVER FAILURE, ACUTE; MONITORING, PHYSIOLOGIC; MULTIPLE ORGAN FAILURE; NECROSIS; RENAL REPLACEMENT THERAPY; REPRODUCIBILITY OF RESULTS; RESPIRATION, ARTIFICIAL; SWINE; TIME FACTORS;

EID: 84875044576     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12042     Document Type: Article

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