Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice

British Journal of Cancer

Volumn 113, Issue 4, 2015, Pages 669-679

  Tanaka, Yuriko ^a   Ito, Sachiko ^a   Oshino, Reina ^a   Chen, Nana ^a   Nishio, Naomi ^a   Isobe, Ken Ichi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

colorectal cancer; GADD34; IL 6; myeloid cells; STAT3; ulcerative colitis

Indexed keywords

AZOXYMETHANE; DEXTRAN SULFATE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PHOSPHOPROTEIN PHOSPHATASE 1; PPP1R15A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CELL PROLIFERATION; COLON; COLON CARCINOGENESIS; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; EXPERIMENTAL COLITIS; FEMALE; HISTOPATHOLOGY; INFLAMMATION; INTESTINE EPITHELIUM CELL; MEDIATOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL TRANSFORMATION; COLITIS; COLON TUMOR; DISEASE MODEL; EPITHELIUM CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; UPREGULATION;

ANIMALS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLITIS; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DNA DAMAGE; EPITHELIAL CELLS; FEMALE; INFLAMMATION; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN PHOSPHATASE 1; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84939259892     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2015.263     Document Type: Article

References (33)

1. Abreu MT. (2010). Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol. 10(2): 131-144.
2. Ambs S, Merriam WG, Bennett WP, Felley-Bosco E, Ogunfusika MO, Oser SM, Klein S, Shields PG, Billiar TR, Harris CC. (1998). Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res. 58(2): 334-341.
3. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Doré J, Antolín M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, JametA, Juste C, Kaci G, Knol J, LakhdariO, Layec S, Le Roux K, Maguin E, Mérieux A, Melo Minardi R, M'Rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD, Bork P. MetaHit Consortium. (2011). Enterotypes of the human gut microbiome. Nature. 473(7346): 174-180.
4. Atreya R, Neurath MF. (2005). Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clin Rev Allergy Immunol. 28(3): 187-196.
5. Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, Neurath MF. (2004). TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity. 21(4): 491-501.
6. Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ. (2013). The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 144(5): 989-1000.e6.
7. Clavarino G, Cláudio N, Dalet A, Terawaki S, Couderc T, Chasson L, Ceppi M, Schmidt EK, Wenger T, Lecuit M, Gatti E, Pierre P. (2012). Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells. Proc Natl Acad Sci USA. 109(8): 3006-3011.
8. Dipple A. (1995). DNA adducts of chemical carcinogens. Carcinogenesis. 16(3): 437-441.
9. Fornace AJ, Alamo I, Hollander MC. (1988). DNA damage-inducible transcripts in mammalian cells. Proc Natl Acad Sci USA. 85(23): 8800-8804.
10. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. (2004). IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-Associated cancer. Cell. 118(3): 285-296.
11. Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. (2009). IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-Associated cancer. Cancer Cell. 15(2): 103-113.
12. Gu M, Ouyang C, Lin W, Zhang T, Cao X, Xia Z, Wang X. (2014). Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR esponse by inhibiting TAK1 serine 412 phosphorylation. J Immunol. 192(6): 2846-2856.
13. Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D. (2009). Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci USA. 106(6): 1832-1837.
14. Herrinton LJ, Liu L, Levin TR, Allison JE, Lewis JD, Velayos F. (2012). Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010. Gastroenterology. 143(2): 382-389.
15. Hollander MC, Zhan Q, Bae I, Fornace AJ. (1997). Mammalian GADD34, an apoptosis- And DNA damage-inducible gene. J Biol Chem. 272(21): 13731-13737.
16. Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, Isobe K. (2015). GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy. Sci Rep. 5: 8327.
17. Jemal A, Center MM, DeSantis C, Ward EM. (2010). Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 19(8): 1893-1907.
18. Kishimoto T. (2005). Interleukin-6: from basic science to medicine-40 years in immunology. Annu Rev Immunol. 23: 1-21.
19. Kojima E, Takeuchi A, Haneda M, Yagi A, Hasegawa T, Yamaki K, Takeda K, Akira S, Shimokata K, Isobe K. (2003). The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB J. 17(11): 1573-1575.
20. Lala PK, Chakraborty C. (2001). Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol. 2(3): 149-156.
21. Li HY, Liu H, Wang CH, Zhang JY, Man JH, Gao YF, Zhang PJ, LiWH, Zhao J, Pan X, Zhou T, Gong WL, Li AL, Zhang XM. (2008). Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat Immunol. 9(5): 533-541.
22. Liu L, Nishio N, Ito S, Tanaka Y, Isobe K. (2014). Negative regulation of GADD34 on myofibroblasts during cutaneous wound healing. Biomed Res Int. 2014: 137049.
23. Mantovani A, Allavena P, Sica A, Balkwill F. (2008). Cancer-related inflammation. Nature. 454(7203): 436-444.
24. Mengesdorf T, Althausen S, Oberndorfer I, Paschen W. (2001). Response of neurons to an irreversible inhibition of endoplasmic reticulum Ca(2+)-ATPase: relationship between global protein synthesis and expression and translation of individual genes. Biochem J. 356(Pt 3): 805-812.
25. Mesman AW, Zijlstra-Willems EM, Kaptein TM, de Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI, Geijtenbeek TB. (2014). Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases. Cell Host Microbe. 16(1): 31-42.
26. Middleton SJ, Shorthouse M, Hunter JO. (1993). Increased nitric oxide synthesis in ulcerative colitis. Lancet. 341(8843): 465-466.
27. Novoa I, Zeng H, Harding HP, Ron D. (2001). Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol. 153(5): 1011-1022.
28. Novoa I, Zhang Y, Zeng H, Jungreis R, Harding HP, Ron D. (2003). Stressinduced gene expression requires programmed recovery from translational repression. EMBO J. 22(5): 1180-1187.
29. Shkoda A, Ruiz PA, Daniel H, Kim SC, Rogler G, Sartor RB, Haller D. (2007). Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology. 132(1): 190-207.
30. Tun X, Yasukawa K, Yamada K. (2014). Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis. Free Radic Biol Med. 74: 108-117.
31. Yu H, Pardoll D, Jove R. (2009). STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 9(11): 798-809.
32. Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD. (2011). The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell. 20(5): 649-660.
33. Zhan Q, Lord KA, Alamo I, Hollander MC, Carrier F, Ron D, Kohn KW, Hoffman B, Liebermann DA, Fornace AJ. (1994). The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol Cell Biol. 14(4): 2361-2371.