Environmental enrichment attenuates the age-related decline in the mRNA expression of steroidogenic enzymes and reduces the methylation state of the steroid 5α-reductase type 1 gene in the rat hippocampus

Molecular and Cellular Endocrinology

Volumn 412, Issue , 2015, Pages 330-338

  Rossetti, María F ^a   Varayoud, Jorgelina ^a   Moreno Piovano, Guillermo S ^a   Luque, Enrique H ^a   Ramos, Jorge G ^a  

^a UNIVERSIDAD NACIONAL DEL LITORAL   (Argentina)

Author keywords

Aging; DNA methylation; Environmental enrichment; Hippocampus; Neurosteroidogenic enzymes

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; CYTOCHROME P450; MESSENGER RNA; STEROID 17ALPHA MONOOXYGENASE; STEROID 5ALPHA REDUCTASE 1; STEROID 5ALPHA REDUCTASE;

3ALPHA HSD GENE; 5ALPHA REDUCTASE 1 GENE; ADULT; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOCHROME P450 17ALPHA HYDROXYLASE GENE; DNA METHYLATION; ENVIRONMENTAL ENRICHMENT; ENVIRONMENTAL EXPOSURE; EPIGENETICS; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MIDDLE AGED; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CLEAVAGE; RAT; SENSORY STIMULATION; SOCIAL STIMULATION; STEROIDOGENESIS; STIMULATION; YOUNG ADULT; ANIMAL; ANIMAL HOUSING; BIOSYNTHESIS; ENZYMOLOGY; GENE EXPRESSION; GENETIC EPIGENESIS; GENETICS; METABOLISM; WISTAR RAT;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; AGING; ANIMALS; BIOSYNTHETIC PATHWAYS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HOUSING, ANIMAL; PROMOTER REGIONS, GENETIC; RATS, WISTAR; RNA, MESSENGER;

EID: 84939259690     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.05.024     Document Type: Article

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